Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Katia Catherine Katia Catherine Karalis, MD, PhD
Affiliated Investigator

Telephone : +30 210 6597 465
Fax : +30 210 6597 545
e-mail : kkarali@bioacademy.gr


Center :

Clinical, Experimental Surgery & Translational Research

Lab Site :

Karalis Lab


Brief Bio

Katia Karalis received her M.D. from Athens University Medical School in 1986. She continued her studies at Cedars-Sinai Medical Center, UCLA, USA and at the National Institutes of Health (NIH), Bethesda MD, USA, as a postdoctoral fellow in Endocrinology. From 1991 she moved to Boston, at the Children's Hospital, Harvard University as a postdoctoral fellow in Pediatrics and Medicine at the Division of Endocrinology. She was trained in Medical Molecular Genetics and Clinical Cytogenetics at the Department of Genetics of Harvard Medical School. From 1994 she joined the faculty at the Department of Pediatrics, Harvard Medical School, initially as Instructor and next as Assistant Professor. She was the recipient of the Department of Medicine Award and of several non-federal and federal grants, including a grant from March of Dimes and a KO8, and an RO1 from NIDDK. Her expertise lies in the fields of physiology and pathophysiology, the biology of the stress response in mammals and the crosstalk between the endocrine, the nervous and the immune system in the development and progress of the inflammatory response. Her team uses mouse models for human diseases together with in vitro approaches to elucidate the role of neuropeptides in the regulation of the inflammatory response, in the development of innate immunity and in the metabolic changes, including food intake and insulin signalling, during inflammation. She is affiliated and has active collaborations with the Division of Endocrinology of Children's Hospital and the Division of Gastroenterology and the Center of Nutrition at MassGeneral Hospital, Harvard Medical School, in Boston, USA.

Selected Publications

Karalis K, Sano H, Redwine J, Listwak S, Wilder RW, Chrousos GP. Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone (CRH) in vivo, Science, 254: 421-23, 1991.

Karalis K, Mastorakos G, Chrousos GP, Tolis G. Somatostatin analogs suppress the inflammatory reaction in vivo, J Clin Invest 93: 2000-6, 1994.

Karalis K, Goodwin G, Majzoub JA. Cortisol blockade of progesterone: a possible molecular mechanism involved in initiation of human labor, Nature Medicine 2: 556-60, 1996.

Karalis K, Kontopoulos E, Muglia L, Majzoub JA. Corticotropin-Releasing Hormone unmasks the proinflammatory effects of epinephrine. ProcNatl Acd Sci 96 (12):9073-7, 1999.

Arbiser JA, Karalis K, Viswanathan A, Koike C, Anand-Apte B, Flynn E, Zetter B, Majzoub JA. Angiogenic properties of Corticotropin-Releasing Hormone. J Invest Derm, 113(5):838, 1999.

Venihaki M, Dikkes P, Carrigan A, Karalis KP. CRH deficiency unmasks the role of IL-6 during inflammation. J. Clin Invest. 108 (8):1159-66. 2001.

Zhao J, Karalis K.P. Regulation of Nuclear Factor-kappa B by CRH in Mouse Thymocytes. Mol Endo16(11): 2561-70. 2002.

Karalis K, Venihaki M, Zhao J, van Vlerken LE, Chandras C. Nuclear factor-kappa B participates in the corticotropin releasing hormone-induced regulation of the pituitary proopiomelanocortin gene. J Biol Chem 279, 12:10837-40. 2004.

Anton PM, Gay J, Mykoniatis A, Pan A, O'Brien M, Brown D, Karalis K, Pothoulakis C.Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation.Proc Natl Acad Sci U S A. 101(22):8503-8, 2004.

Benou C, Wang Y, Imitola J, VanVlerken L, Chandras C, Karalis KP and Khoury SJ. Corticotropin-releasing hormone contributes to the peripheral inflammatory response in experimental autoimmune encephalomyelitis. J Immunol. 174(9):5407-13, 2005.

PubMed:

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