Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Epaminondas Epaminondas Doxakis, PhD, MBA
Investigator - Lecturer Level

Telephone : +30 210 6597 479
Fax : +30 210 6597 545
e-mail : edoxakis@bioacademy.gr


Center :

Basic Research

Lab Site :

Doxakis Lab


Brief Bio

Dr Epaminondas Doxakis received his PhD degree in Neurobiology from Bute Medical School at St-Andrews University, Scotland in 1999 and stayed on until 2000. He studied target field innervation and TrkA receptor mRNA transport in the trigeminal system as well as the mechanisms underlying neurotrophic factor dependence and responsiveness in the ganglia of the peripheral nervous system. He identified novel roles for depolarization in the regulation of neurotrophic factor receptors and participated in the identification of the GFRa-4 receptor and the neurotrophic properties of the macrophage-stimulating protein, MSP, in motor neurons. Following completion of his home service in 2001, he moved to Royal Veterinary College at Edinburgh University, Scotland for three years of postdoctoral work into the versatile serine/threonine kinase HIPK2 signaling during which he identified pro-apoptotic roles in both sensory and sympathetic neurons. At the same time, he was seconded to VA Medical Center, UCSF, USA for work on the HIPK2 transgenic mice. Between 2002 and 2005, Nondas studied part-time at the Edinburgh Management School, Scotland from which he received an MBA degree with attention on setting-up biotech companies. In 2004, he moved to the School of Biosciences at Cardiff University, Wales for work on the role of calponin family member NP25 in neuronal differentiation. In September 2005, he was offered a tenure track research position in the Center of Basic Sciences at BRFΑΑ. Nondas has actively participated in the teaching curricula of the aforementioned institutes, EMBL, and Greek universities.

His continued research interests aim at deciphering mechanisms of neuronal specification and survival in central and peripheral neurons as well as identifying therapeutic targets for Parkinson's and Alzheimer’s diseases. Nondas has placed a particular focus on characterizing the roles of neuronal microRNAs and RNA-binding proteins on these processes.

Selected Publications

Fragkouli A, Koukouraki P, Vlachos IS, Paraskevopoulou MD, Hatzigeorgiou AG, Doxakis E (2017) «Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP». Scientific Reports 7:44507.

Koukouraki P, Doxakis E (2016) «Constitutive translation of human alpha-synuclein is mediated by the 5’ untranslated region». Open Biology, 6(4). pii: 160022.

Fragkouli A, Doxakis E (2014) miR-7 and miR-153 protect neurons against MPP+-induced cell death via upregulation of mTOR pathway. Front Cell Neurosci. 8:182.

Doxakis E (2014) RNA binding proteins: a common denominator of neuronal function and dysfunction. Neurosci Bull. 30: 610-26.

Doxakis E (2013) Principles of miRNA-target regulation in metazoan models. Int J Mol Sci. 14: 16280-302.

Paschou M and Doxakis E (2012) Neurofibromin 1 is a miRNA target in neurons PLoS One. 7: e46773.

Paschou M, Paraskevopoulou MD, Vlachos IS, Koukouraki P, Hatzigeorgiou AG, Doxakis E (2012) miRNA regulons associated with synaptic function PLoS One. 7: e46189.

Doxakis E (2010) Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153. JBC 285: 12726-34.

Doxakis E Howard L, Rohrer H, Davies AM (2008) Hand transcription factors are required for postnatal sympathetic neuron survival. EMBO Rep. 9: 1041-7.

Wiggins AK, Wei G, Doxakis E, Wong C, Tang  AA, Zang K, Luo EJ, Neve RL, Reichardt LF, Huang EJ (2004) Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J. Cell Biol. 167: 257-267.

Doxakis E, Huang EJ, Davies AM (2004) Homeodomain-interacting protein kinase-2 regulates apoptosis in developing sensory and sympathetic neurons. Curr. Biol.  14: 1761-1765.

PubMed:

PubMed Link