Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Research Highlights

2022
Predicting protein–membrane interfaces of peripheral membrane proteins using ensemble machine learning Predicting protein–membrane interfaces of peripheral membrane proteins using ensemble machine learning

Alexios Chatzigoulas and Zoe Cournia recently published a study in Briefings in Bioinformatics

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An integrin axis induces IFN-β production in plasmacytoid dendritic cells An integrin axis induces IFN-β production in plasmacytoid dendritic cells

Evangelia Kourepini, Nikolaos Paschalidis and Davina Simoes, members of the Cellular Immunology Laboratory of Vily Panoutsakopoulou published a study in the Journal of Cell Biology

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Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication

Paschalis Sideras, Athanasios Stavropoulos and colleagues recently published a study in Science Signaling

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MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity

Andreas Papapetropoulos, Antonia Katsouda and Colleagues Recently Published a Study in JEM

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Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model

Stelios Psarras and his colleagues recently published a study in Cellular and Molecular Life Sciences Journal

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Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2 Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2

Vassilis G. Gorgoulis and collaborators published a research article in the Computational and Structural Biotechnology Journal

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TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthma TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthma

Georgina Xanthou and her colleagues recently published a study in Allergy

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Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models

Maria Xilouri, Panagiota Mavroeidi and colleagues recently published a study in Autophagy

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Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine

Constantin Tamvakopoulos and colleagues recently published a study in the Journal of Medicinal Chemistry

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2021
RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1 RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1

Vassilis G. Gorgoulis and colleagues recently published a study in EMBO Reports

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Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK

Despina Sanoudou and colleagues recently published a paper in Metabolism - Clinical and Experimental

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CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammation CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammation

Evangelos Andreakos, Sofia Tagkareli and colleagues recently published a study in Allergy

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The effect of S427F mutation on RXRα activity depends on its dimeric partner The effect of S427F mutation on RXRα activity depends on its dimeric partner

Apostolos Klinakis, Zoe Cournia and colleagues recently published a study in Chemical Science

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N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains. N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains.

Theodoros Rampias, Apostolos Klinakis and Zoe Cournia recently published a study in Computational and Structural Biotechnology Journal

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Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies

Panagiotis Politis, Dimitris Gkikas and colleagues recently published a study in PNAS

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Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung

Maria Semitekolou, Georgina Xanthou and colleagues recently published a paper in Journal of Experimental and Clinical Cancer Research

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Prox1 inhibits neurite outgrowth during central nervous system development Prox1 inhibits neurite outgrowth during central nervous system development

Panagiotis Politis, Valeria Kaltezioti and colleagues recently published a study in Cellular and Molecular Life Sciences

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Regulatory T cell transcriptomic reprogramming characterizes adverse events by checkpoint inhibitors in solid tumors Regulatory T cell transcriptomic reprogramming characterizes adverse events by checkpoint inhibitors in solid tumors

Panayotis Verginis, Themis Alissafi and colleagues recently published a study in Cancer Immunology Research

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A Novel SNCA A30G Mutation Causes Familial Parkinson's Disease A Novel SNCA A30G Mutation Causes Familial Parkinson's Disease

Leonidas Stefanis and colleagues recently published a paper in Movement Disorders

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A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord

Dimitris Beis, Vasiliki Tsata and colleagues recently published a manuscript in Developmental Cell

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2020
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Evangelos Andreakos and colleagues recently published a paper in Nature Immunology

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Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats

Leonidas Stefanis, Alexia Polissidis and colleagues recently published a study in Movement Disorders

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Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Panayotis Verginis and colleagues recently published a paper in Cell

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Gender-specific transcriptional profiles identified in β-thalassemia patients Gender-specific transcriptional profiles identified in β-thalassemia patients

Eleni Katsantoni and colleagues recently published a paper in Haematologica

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Mitochondrial oxidative damage underlies regulatory T cell defects in autoimmunity Mitochondrial oxidative damage underlies regulatory T cell defects in autoimmunity

Panayotis Verginis and colleagues recently published a study in Cell Metabolism

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Unravelling the effect of the E545K mutation on PI3Ka kinase† Unravelling the effect of the E545K mutation on PI3Ka kinase†

Zoe Cournia and colleagues recently published a paper in Chemical Science

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Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD) Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD)

Katia Catherine Karalis and colleagues recently published a study in Molecular Psychiatry

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Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus

Dimitrios Boumpas and colleagues recently published a study in Annals of the Rheumatic Diseases

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2019
An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion

Panayotis Verginis and colleagues recently published a study in Nature Immunology

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A Deep Learning Framework for Predicting Response to Therapy in Cancer A Deep Learning Framework for Predicting Response to Therapy in Cancer

Vassilis Gorgoulis, Konstantinos Vougas and colleagues recently published a study in Cell Reports

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CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus

Katia Catherine Karalis and Colleagues recently published a study in Cell Reports

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Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia

Vassilis Gorgoulis and colleagues recently published a study in Nature

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Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity

Dimitris Boumpas and colleagues recently published a study in Annals of the Rheumatic Diseases Journal

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2018
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

Panayotis Verginis, Dimitrios Boumpas and colleagues published a new study in Cell Reports

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Plasmacytoid dendritic cells drive acute asthma exacerbations Plasmacytoid dendritic cells drive acute asthma exacerbations

Evangelos Andreakos and colleagues recently published a study in JACI

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Senescence and Senotherapeutics: a New Field in Cancer Therapy Senescence and Senotherapeutics: a New Field in Cancer Therapy

Vassilis Gorgoulis and colleagues recently published a paper in Pharmacology & Therapeutics

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Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

Vassilis Gorgoulis and colleagues recently published a study in Nature Communications

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Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells

Panayotis Verginis and colleagues recently published a study in the Journal of Clinical Investigation

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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Vassilis Gorgoulis and colleagues recently published a study in Genome Biology

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Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion

Katia Karalis and colleagues recently published a new study in Cell Reports

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2017
Tregs restrain dendritic cell autophagy to ameliorate autoimmunity Tregs restrain dendritic cell autophagy to ameliorate autoimmunity

Panayotis Verginis and colleagues recently published a study in JCI

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Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

A new paper by Evangelos Andreakos and colleagues was recently published in Immunity. A commentary followed from the same issue of Immunity, and the article was also featured in Nature Reviews Immunology – Highlights.

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Nurr1:RXRα Heterodimer Activation as Monotherapy for Parkinson’s Disease Nurr1:RXRα Heterodimer Activation as Monotherapy for Parkinson’s Disease

Demetrios Vassilatis and colleagues recently published a study in PNAS

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Activin-A co-opts IRF4 and AhR Signaling to Induce Human Regulatory T Cells that Restrain Asthmatic Responses Activin-A co-opts IRF4 and AhR Signaling to Induce Human Regulatory T Cells that Restrain Asthmatic Responses

A new paper by Georgina Xanthou and her colleagues was recently published in PNAS

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Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling

Ioannis Serafimidis and colleagues recently published a paper in PLOS Biology.

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2016
DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas

A new study was published in Cell by Vassilis Gorgoulis and colleagues

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Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats

Leonidas Stefanis, Maria Xilouri and colleagues published a study in Autophagy

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Nuclear receptor NR5A2 controls neural stem cell fate decisions during development Nuclear receptor NR5A2 controls neural stem cell fate decisions during development

A new paper was recently published online in Nature Communications from the Panagiotis Politis Group

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Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Vassilis G. Gorgoulis and colleagues published a study in Nature Cell Biology

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KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis

Apostolos Klinakis and colleagues conducted a study that was published in Nature Communications.

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2015
Study in the Design of Novel Targeted Molecules for the Treatment of Solid Tumors Study in the Design of Novel Targeted Molecules for the Treatment of Solid Tumors

Constantin Tamvakopoulos and colleagues published a paper in Cancer Research.

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