Research
Research Highlights
Identification and evolution of predictors of Sjögren's disease-associated mucosa-associated lymphoid tissue lymphoma development over time: a case-control study
Athanasios Tzioufas and colleagues recently published a study in The Lancet Rheumatology
Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Vassilis Gorgoulis and colleagues recently published a study in Molecular Cancer
Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development
Panayotis Verginis and colleagues recently published a study in Nature Communications
Neutrophil-derived Activin-A moderates their pro-NETotic activity and attenuates collateral tissue damage caused by Influenza A virus infection
Paschalis Sideras, Georgios Divolis, Evgenia Synolaki and colleagues recently published a study in Frontiers in Immunology
Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6- dependent pathways
Vassilis G. Gorgoulis, Athanasios Tzioufas and collaborators published a research article in Annals of the Rheumatic Diseases (ARD)
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells
Vassilis G. Gorgoulis and collaborators published a research article in Molecular Cell
Transcriptomic and proteomic profiling reveals distinct pathogenic features of peripheral non-classical monocytes in systemic lupus erythematosus
Dimitrios Boumpas and colleagues recently published a study in Clinical Immunology
A network-based approach reveals long non-coding RNAs associated with disease activity in lupus nephritis: key pathways for flare and potential biomarkers to be used as liquid biopsies
Dimitrios Boumpas and colleagues recently published a study in Frontiers in Immunology
Decoding of translation-regulating entities reveals heterogeneous translation deficiency patterns in cellular senescence.
Vassilis Gorgoulis and colleagues have recently published a paper in Aging Cell
A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer
Vassilis Gorgoulis and collaborators have recently published a paper in the Journal of Experimental & Clinical Cancer Research
Novel H2S-Releasing Bifunctional Antihistamine Molecules with Improved Antipruritic and Reduced Sedative Actions
Andreas Papapetropoulos and colleagues recently published a paper in the Journal of Medicinal Chemistry
Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity
Sarantis Gagos and colleagues recently published a study in Nature Communications
The genomic landscape of ANCA-associated vasculitis: Distinct transcriptional signatures, molecular endotypes and comparison with systemic lupus erythematosus
Dimitris Boumpas, Aggelos Banos and their colleagues recently published a study in Frontiers in Immunology
HGCA2.0: An RNA-Seq Based Webtool for Gene Coexpression Analysis in Homo sapiens
Ioannis Michalopoulos and colleagues recently published a study in Cells
ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus
Dimitrios Boumpas, Panayotis Verginis and their colleagues recently published a study in Sciences Advances
Predicting protein–membrane interfaces of peripheral membrane proteins using ensemble machine learning
Alexios Chatzigoulas and Zoe Cournia recently published a study in Briefings in Bioinformatics
An integrin axis induces IFN-β production in plasmacytoid dendritic cells
Evangelia Kourepini, Nikolaos Paschalidis and Davina Simoes, members of the Cellular Immunology Laboratory of Vily Panoutsakopoulou published a study in the Journal of Cell Biology
Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication
Paschalis Sideras, Athanasios Stavropoulos and colleagues recently published a study in Science Signaling
MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity
Andreas Papapetropoulos, Antonia Katsouda and Colleagues Recently Published a Study in JEM
Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model
Stelios Psarras and his colleagues recently published a study in Cellular and Molecular Life Sciences Journal
Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2
Vassilis G. Gorgoulis and collaborators published a research article in the Computational and Structural Biotechnology Journal
TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthma
Georgina Xanthou and her colleagues recently published a study in Allergy
Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis
Vassilis G. Gorgoulis and collaborators published a research article in the European Respiratory Journal
Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models
Maria Xilouri, Panagiota Mavroeidi and colleagues recently published a study in Autophagy
Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine
Constantin Tamvakopoulos and colleagues recently published a study in the Journal of Medicinal Chemistry
RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1
Vassilis G. Gorgoulis and colleagues recently published a study in EMBO Reports
Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK
Despina Sanoudou and colleagues recently published a paper in Metabolism - Clinical and Experimental
CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammation
Evangelos Andreakos, Sofia Tagkareli and colleagues recently published a study in Allergy
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
Vassilis G. Gorgoulis and colleagues recently published a study in Molecular Cell
The effect of S427F mutation on RXRα activity depends on its dimeric partner
Apostolos Klinakis, Zoe Cournia and colleagues recently published a study in Chemical Science
N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains.
Theodoros Rampias, Apostolos Klinakis and Zoe Cournia recently published a study in Computational and Structural Biotechnology Journal
Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies
Panagiotis Politis, Dimitris Gkikas and colleagues recently published a study in PNAS
Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung
Maria Semitekolou, Georgina Xanthou and colleagues recently published a paper in Journal of Experimental and Clinical Cancer Research
Prox1 inhibits neurite outgrowth during central nervous system development
Panagiotis Politis, Valeria Kaltezioti and colleagues recently published a study in Cellular and Molecular Life Sciences
Crosstalk between coagulation and complement activation promotes cardiac dysfunction in arrhythmogenic right ventricular cardiomyopathy
Manolis Mavroidis and colleagues recently published a study in Theranostics
Regulatory T cell transcriptomic reprogramming characterizes adverse events by checkpoint inhibitors in solid tumors
Panayotis Verginis, Themis Alissafi and colleagues recently published a study in Cancer Immunology Research
A Novel SNCA A30G Mutation Causes Familial Parkinson's Disease
Leonidas Stefanis and colleagues recently published a paper in Movement Disorders
A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord
Dimitris Beis, Vasiliki Tsata and colleagues recently published a manuscript in Developmental Cell
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison
Evangelos Andreakos and colleagues recently published a paper in Nature Immunology
Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats
Leonidas Stefanis, Alexia Polissidis and colleagues recently published a study in Movement Disorders
Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity
Panayotis Verginis and colleagues recently published a paper in Cell
Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes
Dimitris Thanos, Marios Agelopoulos and colleagues recently published a study in the EMBO Journal
Gender-specific transcriptional profiles identified in β-thalassemia patients
Eleni Katsantoni and colleagues recently published a paper in Haematologica
18F-FDG PET/CT brain glucose metabolism as a marker of different types of depression comorbidity in chronic heart failure patients with impaired systolic function
Sofia Chatziioannou and colleagues recently published a paper in European Journal of Heart Failure
Mitochondrial oxidative damage underlies regulatory T cell defects in autoimmunity
Panayotis Verginis and colleagues recently published a study in Cell Metabolism
Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α–dependent pathways
Georgina Xanthou and colleagues recently published a study in PNAS
mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing
Popi Syntichaki, Christos Zervas and colleagues recently published a paper in eLife
Unravelling the effect of the E545K mutation on PI3Ka kinase†
Zoe Cournia and colleagues recently published a paper in Chemical Science
Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD)
Katia Catherine Karalis and colleagues recently published a study in Molecular Psychiatry
Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus
Dimitrios Boumpas and colleagues recently published a study in Annals of the Rheumatic Diseases
An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion
Panayotis Verginis and colleagues recently published a study in Nature Immunology
A Deep Learning Framework for Predicting Response to Therapy in Cancer
Vassilis Gorgoulis, Konstantinos Vougas and colleagues recently published a study in Cell Reports
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus
Katia Catherine Karalis and Colleagues recently published a study in Cell Reports
Machine learning and data mining frameworks for predicting drugresponse in cancer: An overview and a novelin silicoscreening processbased on association rule mining
Vassilis G. Gorgoulis, Konstantinos Vougas and colleagues recently published in Pharmacology and Therapeutics
Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia
Vassilis Gorgoulis and colleagues recently published a study in Nature
Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity
Dimitris Boumpas and colleagues recently published a study in Annals of the Rheumatic Diseases Journal
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models
Maria Xilouri and colleagues recently published a study in Acta Neuropathologica
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion
Panayotis Verginis, Dimitrios Boumpas and colleagues published a new study in Cell Reports
Plasmacytoid dendritic cells drive acute asthma exacerbations
Evangelos Andreakos and colleagues recently published a study in JACI
Senescence and Senotherapeutics: a New Field in Cancer Therapy
Vassilis Gorgoulis and colleagues recently published a paper in Pharmacology & Therapeutics
The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression
Dimitris Thanos and colleagues recently published a study in Molecular cell
Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
Vassilis Gorgoulis and colleagues recently published a study in Nature Communications
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells
Panayotis Verginis and colleagues recently published a study in the Journal of Clinical Investigation
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Vassilis Gorgoulis and colleagues recently published a study in Genome Biology
18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomographic Imaging Detects Aortic Wall Inflammation in Patients With Repaired Coarctation of Aorta
Constantinos Anagnostopoulos and colleagues recently published a paper in Circulation Cardiovascular Imaging
Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion
Katia Karalis and colleagues recently published a new study in Cell Reports
Tregs restrain dendritic cell autophagy to ameliorate autoimmunity
Panayotis Verginis and colleagues recently published a study in JCI
Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness
A new paper by Evangelos Andreakos and colleagues was recently published in Immunity. A commentary followed from the same issue of Immunity, and the article was also featured in Nature Reviews Immunology – Highlights.
Nurr1:RXRα Heterodimer Activation as Monotherapy for Parkinson’s Disease
Demetrios Vassilatis and colleagues recently published a study in PNAS
Activin-A co-opts IRF4 and AhR Signaling to Induce Human Regulatory T Cells that Restrain Asthmatic Responses
A new paper by Georgina Xanthou and her colleagues was recently published in PNAS
Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling
Ioannis Serafimidis and colleagues recently published a paper in PLOS Biology.
Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication
Sarantis Gagos and colleagues conducted a study that was published in EMBO Reports
DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas
A new study was published in Cell by Vassilis Gorgoulis and colleagues
The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions
Eleni Katsantoni and colleagues recently published a study in Nucleic Acids Research
Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats
Leonidas Stefanis, Maria Xilouri and colleagues published a study in Autophagy
Nuclear receptor NR5A2 controls neural stem cell fate decisions during development
A new paper was recently published online in Nature Communications from the Panagiotis Politis Group
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
Vassilis G. Gorgoulis and colleagues published a study in Nature Cell Biology
KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis
Apostolos Klinakis and colleagues conducted a study that was published in Nature Communications.
Genetic Studies in Flies Shed New Light on How Cells Modulate their Adhesion Properties when Exposed to Physical Forces
Christos Zervas and colleagues published a paper in Cell Reports.
GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum
Kostas Vekrellis and colleagues published a study in Brain.
Study in the Design of Novel Targeted Molecules for the Treatment of Solid Tumors
Constantin Tamvakopoulos and colleagues published a paper in Cancer Research.
Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18
Dr Capetanaki and colleagues published a study in Nature Medicine.
Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene Expression
Dr. Thanos and colleagues published a paper in Cell Reports.
2024
Identification and evolution of predictors of Sjögren's disease-associated mucosa-associated lymphoid tissue lymphoma development over time: a case-control studyAthanasios Tzioufas and colleagues recently published a study in The Lancet Rheumatology
Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapyVassilis Gorgoulis and colleagues recently published a study in Molecular Cancer
Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour developmentPanayotis Verginis and colleagues recently published a study in Nature Communications
Neutrophil-derived Activin-A moderates their pro-NETotic activity and attenuates collateral tissue damage caused by Influenza A virus infectionPaschalis Sideras, Georgios Divolis, Evgenia Synolaki and colleagues recently published a study in Frontiers in Immunology
2023
Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6- dependent pathwaysVassilis G. Gorgoulis, Athanasios Tzioufas and collaborators published a research article in Annals of the Rheumatic Diseases (ARD)
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cellsVassilis G. Gorgoulis and collaborators published a research article in Molecular Cell
Transcriptomic and proteomic profiling reveals distinct pathogenic features of peripheral non-classical monocytes in systemic lupus erythematosusDimitrios Boumpas and colleagues recently published a study in Clinical Immunology
A network-based approach reveals long non-coding RNAs associated with disease activity in lupus nephritis: key pathways for flare and potential biomarkers to be used as liquid biopsiesDimitrios Boumpas and colleagues recently published a study in Frontiers in Immunology
Decoding of translation-regulating entities reveals heterogeneous translation deficiency patterns in cellular senescence.Vassilis Gorgoulis and colleagues have recently published a paper in Aging Cell
A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancerVassilis Gorgoulis and collaborators have recently published a paper in the Journal of Experimental & Clinical Cancer Research
Novel H2S-Releasing Bifunctional Antihistamine Molecules with Improved Antipruritic and Reduced Sedative ActionsAndreas Papapetropoulos and colleagues recently published a paper in the Journal of Medicinal Chemistry
Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activitySarantis Gagos and colleagues recently published a study in Nature Communications
The genomic landscape of ANCA-associated vasculitis: Distinct transcriptional signatures, molecular endotypes and comparison with systemic lupus erythematosusDimitris Boumpas, Aggelos Banos and their colleagues recently published a study in Frontiers in Immunology
HGCA2.0: An RNA-Seq Based Webtool for Gene Coexpression Analysis in Homo sapiensIoannis Michalopoulos and colleagues recently published a study in Cells
2022
ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosusDimitrios Boumpas, Panayotis Verginis and their colleagues recently published a study in Sciences Advances
Predicting protein–membrane interfaces of peripheral membrane proteins using ensemble machine learningAlexios Chatzigoulas and Zoe Cournia recently published a study in Briefings in Bioinformatics
An integrin axis induces IFN-β production in plasmacytoid dendritic cellsEvangelia Kourepini, Nikolaos Paschalidis and Davina Simoes, members of the Cellular Immunology Laboratory of Vily Panoutsakopoulou published a study in the Journal of Cell Biology
Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxicationPaschalis Sideras, Athanasios Stavropoulos and colleagues recently published a study in Science Signaling
MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesityAndreas Papapetropoulos, Antonia Katsouda and Colleagues Recently Published a Study in JEM
Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure modelStelios Psarras and his colleagues recently published a study in Cellular and Molecular Life Sciences Journal
Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2Vassilis G. Gorgoulis and collaborators published a research article in the Computational and Structural Biotechnology Journal
TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthmaGeorgina Xanthou and her colleagues recently published a study in Allergy
Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesisVassilis G. Gorgoulis and collaborators published a research article in the European Respiratory Journal
Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy modelsMaria Xilouri, Panagiota Mavroeidi and colleagues recently published a study in Autophagy
Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of GemcitabineConstantin Tamvakopoulos and colleagues recently published a study in the Journal of Medicinal Chemistry
2021
RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1Vassilis G. Gorgoulis and colleagues recently published a study in EMBO Reports
Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPKDespina Sanoudou and colleagues recently published a paper in Metabolism - Clinical and Experimental
CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammationEvangelos Andreakos, Sofia Tagkareli and colleagues recently published a study in Allergy
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganizationVassilis G. Gorgoulis and colleagues recently published a study in Molecular Cell
The effect of S427F mutation on RXRα activity depends on its dimeric partnerApostolos Klinakis, Zoe Cournia and colleagues recently published a study in Chemical Science
N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains.Theodoros Rampias, Apostolos Klinakis and Zoe Cournia recently published a study in Computational and Structural Biotechnology Journal
Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignanciesPanagiotis Politis, Dimitris Gkikas and colleagues recently published a study in PNAS
Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lungMaria Semitekolou, Georgina Xanthou and colleagues recently published a paper in Journal of Experimental and Clinical Cancer Research
Prox1 inhibits neurite outgrowth during central nervous system developmentPanagiotis Politis, Valeria Kaltezioti and colleagues recently published a study in Cellular and Molecular Life Sciences
Crosstalk between coagulation and complement activation promotes cardiac dysfunction in arrhythmogenic right ventricular cardiomyopathyManolis Mavroidis and colleagues recently published a study in Theranostics
Regulatory T cell transcriptomic reprogramming characterizes adverse events by checkpoint inhibitors in solid tumorsPanayotis Verginis, Themis Alissafi and colleagues recently published a study in Cancer Immunology Research
A Novel SNCA A30G Mutation Causes Familial Parkinson's DiseaseLeonidas Stefanis and colleagues recently published a paper in Movement Disorders
A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cordDimitris Beis, Vasiliki Tsata and colleagues recently published a manuscript in Developmental Cell
2020
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparisonEvangelos Andreakos and colleagues recently published a paper in Nature Immunology
Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic RatsLeonidas Stefanis, Alexia Polissidis and colleagues recently published a study in Movement Disorders
Innate Immune Training of Granulopoiesis Promotes Anti-tumor ActivityPanayotis Verginis and colleagues recently published a paper in Cell
Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytesDimitris Thanos, Marios Agelopoulos and colleagues recently published a study in the EMBO Journal
Gender-specific transcriptional profiles identified in β-thalassemia patientsEleni Katsantoni and colleagues recently published a paper in Haematologica
18F-FDG PET/CT brain glucose metabolism as a marker of different types of depression comorbidity in chronic heart failure patients with impaired systolic functionSofia Chatziioannou and colleagues recently published a paper in European Journal of Heart Failure
Mitochondrial oxidative damage underlies regulatory T cell defects in autoimmunityPanayotis Verginis and colleagues recently published a study in Cell Metabolism
Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α–dependent pathwaysGeorgina Xanthou and colleagues recently published a study in PNAS
mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageingPopi Syntichaki, Christos Zervas and colleagues recently published a paper in eLife
Unravelling the effect of the E545K mutation on PI3Ka kinase†Zoe Cournia and colleagues recently published a paper in Chemical Science
Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD)Katia Catherine Karalis and colleagues recently published a study in Molecular Psychiatry
Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosusDimitrios Boumpas and colleagues recently published a study in Annals of the Rheumatic Diseases
2019
An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasionPanayotis Verginis and colleagues recently published a study in Nature Immunology
A Deep Learning Framework for Predicting Response to Therapy in CancerVassilis Gorgoulis, Konstantinos Vougas and colleagues recently published a study in Cell Reports
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult HippocampusKatia Catherine Karalis and Colleagues recently published a study in Cell Reports
Machine learning and data mining frameworks for predicting drugresponse in cancer: An overview and a novelin silicoscreening processbased on association rule miningVassilis G. Gorgoulis, Konstantinos Vougas and colleagues recently published in Pharmacology and Therapeutics
Apidima Cave fossils provide earliest evidence of Homo sapiens in EurasiaVassilis Gorgoulis and colleagues recently published a study in Nature
Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severityDimitris Boumpas and colleagues recently published a study in Annals of the Rheumatic Diseases Journal
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy modelsMaria Xilouri and colleagues recently published a study in Acta Neuropathologica
2018
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent FashionPanayotis Verginis, Dimitrios Boumpas and colleagues published a new study in Cell Reports
Plasmacytoid dendritic cells drive acute asthma exacerbationsEvangelos Andreakos and colleagues recently published a study in JACI
Senescence and Senotherapeutics: a New Field in Cancer TherapyVassilis Gorgoulis and colleagues recently published a paper in Pharmacology & Therapeutics
The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene ExpressionDimitris Thanos and colleagues recently published a study in Molecular cell
Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246Vassilis Gorgoulis and colleagues recently published a study in Nature Communications
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cellsPanayotis Verginis and colleagues recently published a study in the Journal of Clinical Investigation
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instabilityVassilis Gorgoulis and colleagues recently published a study in Genome Biology
18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomographic Imaging Detects Aortic Wall Inflammation in Patients With Repaired Coarctation of AortaConstantinos Anagnostopoulos and colleagues recently published a paper in Circulation Cardiovascular Imaging
Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin SecretionKatia Karalis and colleagues recently published a new study in Cell Reports
2017
Tregs restrain dendritic cell autophagy to ameliorate autoimmunityPanayotis Verginis and colleagues recently published a study in JCI
Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host FitnessA new paper by Evangelos Andreakos and colleagues was recently published in Immunity. A commentary followed from the same issue of Immunity, and the article was also featured in Nature Reviews Immunology – Highlights.
Nurr1:RXRα Heterodimer Activation as Monotherapy for Parkinson’s DiseaseDemetrios Vassilatis and colleagues recently published a study in PNAS
Activin-A co-opts IRF4 and AhR Signaling to Induce Human Regulatory T Cells that Restrain Asthmatic ResponsesA new paper by Georgina Xanthou and her colleagues was recently published in PNAS
Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signallingIoannis Serafimidis and colleagues recently published a paper in PLOS Biology.
2016
Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replicationSarantis Gagos and colleagues conducted a study that was published in EMBO Reports
DNA Damage Signaling Instructs Polyploid Macrophage Fate in GranulomasA new study was published in Cell by Vassilis Gorgoulis and colleagues
The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positionsEleni Katsantoni and colleagues recently published a study in Nucleic Acids Research
Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in ratsLeonidas Stefanis, Maria Xilouri and colleagues published a study in Autophagy
Nuclear receptor NR5A2 controls neural stem cell fate decisions during developmentA new paper was recently published online in Nature Communications from the Panagiotis Politis Group
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensingVassilis G. Gorgoulis and colleagues published a study in Nature Cell Biology
KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesisApostolos Klinakis and colleagues conducted a study that was published in Nature Communications.
Genetic Studies in Flies Shed New Light on How Cells Modulate their Adhesion Properties when Exposed to Physical ForcesChristos Zervas and colleagues published a paper in Cell Reports.
GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatumKostas Vekrellis and colleagues published a study in Brain.
2015
Study in the Design of Novel Targeted Molecules for the Treatment of Solid TumorsConstantin Tamvakopoulos and colleagues published a paper in Cancer Research.
Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18Dr Capetanaki and colleagues published a study in Nature Medicine.
Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene ExpressionDr. Thanos and colleagues published a paper in Cell Reports.
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