Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Research Highlights :CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammation

 

 

Evangelos Andreakos, Sofia Tagkareli and colleagues recently published a study in Allergy

 

This work addresses the important question of functional heterogeneity of FoxP3+ regulatory T cells (Tregs) in the context of allergic airway inflammation. It reveals a subpopulation of Tregs, marked by the expression of CD103, that selectively inhibits Th2-mediated inflammatory responses while sparing Th1 activity. This population exhibits high levels of expression of IL-10 and immunosuppressive molecules such as KLRG1, ICOS and CD127, high regulatory activity, and drives the resolution of allergic airway inflammation and experimental asthma with important therapeutic implications.

 

 


pubmed

CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammation
Tagkareli S, Salagianni M, Galani IE, Manioudaki M, Pavlos E, Thanopoulou K, Andreakos E.  Allergy. 2021 Oct 17. doi: 10.1111/all.15144.