This work addresses the important question of functional heterogeneity of FoxP3+ regulatory T cells (Tregs) in the context of allergic airway inflammation. It reveals a subpopulation of Tregs, marked by the expression of CD103, that selectively inhibits Th2-mediated inflammatory responses while sparing Th1 activity. This population exhibits high levels of expression of IL-10 and immunosuppressive molecules such as KLRG1, ICOS and CD127, high regulatory activity, and drives the resolution of allergic airway inflammation and experimental asthma with important therapeutic implications.
CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammation
Tagkareli S, Salagianni M, Galani IE, Manioudaki M, Pavlos E, Thanopoulou K, Andreakos E. Allergy. 2021 Oct 17. doi: 10.1111/all.15144.