Επιστημονικά Επιτεύγματα - BRFAA - Ίδρυμα Ιατροβιολογικών Ερευνών, Ακαδημίας Αθηνών

2025

An evolutionarily conserved constellation of functional cis-elements programs the virus-responsive fate of the human (epi)genome

Marios Agelopoulos and colleagues published a study in the journal Nucleic Acids Research

[Περισσότερα]

Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog

Vassilis Gorgoulis and colleagues recently published a study in Nature Aging

[Περισσότερα]

2024

Identification and evolution of predictors of Sjögren's disease-associated mucosa-associated lymphoid tissue lymphoma development over time: a case-control study

Ο Αθανάσιος Τζιούφας και οι συνάδελφοι του δημοσίευσαν πρόσφατα μια μελέτη στο περιοδικό The Lancet Rheumatology

[Περισσότερα]

Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy

Vassilis Gorgoulis and colleagues recently published a study in Molecular Cancer

[Περισσότερα]

Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development

Panayotis Verginis and colleagues recently published a study in Nature Communications

[Περισσότερα]

Neutrophil-derived Activin-A moderates their pro-NETotic activity and attenuates collateral tissue damage caused by Influenza A virus infection

Paschalis Sideras, Georgios Divolis, Evgenia Synolaki and colleagues recently published a study in Frontiers in Immunology

[Περισσότερα]

2023

Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6- dependent pathways

Vassilis G. Gorgoulis, Athanasios Tzioufas and collaborators published a research article in Annals of the Rheumatic Diseases (ARD)

[Περισσότερα]

A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells

Vassilis G. Gorgoulis and collaborators published a research article in Molecular Cell

[Περισσότερα]

Transcriptomic and proteomic profiling reveals distinct pathogenic features of peripheral non-classical monocytes in systemic lupus erythematosus

Dimitrios Boumpas and colleagues recently published a study in Clinical Immunology

[Περισσότερα]

A network-based approach reveals long non-coding RNAs associated with disease activity in lupus nephritis: key pathways for flare and potential biomarkers to be used as liquid biopsies

Dimitrios Boumpas and colleagues recently published a study in Frontiers in Immunology

[Περισσότερα]

Decoding of translation-regulating entities reveals heterogeneous translation deficiency patterns in cellular senescence.

Vassilis Gorgoulis and colleagues have recently published a paper in Aging Cell

[Περισσότερα]

A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer

Vassilis Gorgoulis and collaborators have recently published a paper in the Journal of Experimental & Clinical Cancer Research

[Περισσότερα]

Novel H2S-Releasing Bifunctional Antihistamine Molecules with Improved Antipruritic and Reduced Sedative Actions

Andreas Papapetropoulos and colleagues recently published a paper in the Journal of Medicinal Chemistry

[Περισσότερα]

Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity

Sarantis Gagos and colleagues recently published a study in Nature Communications

[Περισσότερα]

The genomic landscape of ANCA-associated vasculitis: Distinct transcriptional signatures, molecular endotypes and comparison with systemic lupus erythematosus

Dimitris Boumpas, Aggelos Banos and their colleagues recently published a study in Frontiers in Immunology

[Περισσότερα]

HGCA2.0: An RNA-Seq Based Webtool for Gene Coexpression Analysis in Homo sapiens

Ioannis Michalopoulos and colleagues recently published a study in Cells

[Περισσότερα]

2022

ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus

Dimitrios Boumpas, Panayotis Verginis and their colleagues recently published a study in Sciences Advances

[Περισσότερα]

Predicting protein–membrane interfaces of peripheral membrane proteins using ensemble machine learning

Alexios Chatzigoulas and Zoe Cournia recently published a study in Briefings in Bioinformatics

[Περισσότερα]

An integrin axis induces IFN-β production in plasmacytoid dendritic cells

Evangelia Kourepini, Nikolaos Paschalidis and Davina Simoes - members of the Cellular Immunology Laboratory of Vily Panoutsakopoulou - published a study in the Journal of Cell Biology

[Περισσότερα]

Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication

Paschalis Sideras, Athanasios Stavropoulos and colleagues recently published a study in Science Signaling

[Περισσότερα]

MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity

Andreas Papapetropoulos, Antonia Katsouda and Colleagues Recently Published a Study in JEM

[Περισσότερα]

Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model

Stelios Psarras and his colleagues recently published a study in Cellular and Molecular Life Sciences Journal

[Περισσότερα]

Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2

Vassilis G. Gorgoulis and collaborators published a research article in the Computational and Structural Biotechnology Journal

[Περισσότερα]

TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthma

Georgina Xanthou and her colleagues recently published a study in Allergy

[Περισσότερα]

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

Vassilis G. Gorgoulis and collaborators published a research article in the European Respiratory Journal

[Περισσότερα]

Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models

Maria Xilouri, Panagiota Mavroeidi and colleagues recently published a study in Autophagy

[Περισσότερα]

Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine

Constantin Tamvakopoulos and colleagues recently published a study in the Journal of Medicinal Chemistry

[Περισσότερα]

2021

RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1

Vassilis G. Gorgoulis and colleagues recently published a study in EMBO Reports

[Περισσότερα]

Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK

Despina Sanoudou and colleagues recently published a paper in Metabolism - Clinical and Experimental

[Περισσότερα]

CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammation

Evangelos Andreakos, Sofia Tagkareli and colleagues recently published a study in Allergy

[Περισσότερα]

A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

Vassilis G. Gorgoulis and colleagues recently published a study in Molecular Cell

[Περισσότερα]

The effect of S427F mutation on RXRα activity depends on its dimeric partner

Apostolos Klinakis, Zoe Cournia and colleagues recently published a study in Chemical Science

[Περισσότερα]

N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains.

Theodoros Rampias, Apostolos Klinakis and Zoe Cournia recently published a study in Computational and Structural Biotechnology Journal

[Περισσότερα]

Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies

Panagiotis Politis, Dimitris Gkikas and colleagues recently published a study in PNAS

[Περισσότερα]

Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung

Maria Semitekolou, Georgina Xanthou and colleagues recently published a paper in Journal of Experimental and Clinical Cancer Research

[Περισσότερα]

Prox1 inhibits neurite outgrowth during central nervous system development

Panagiotis Politis, Valeria Kaltezioti and colleagues recently published a study in Cellular and Molecular Life Sciences

[Περισσότερα]

Crosstalk between coagulation and complement activation promotes cardiac dysfunction in arrhythmogenic right ventricular cardiomyopathy

Manolis Mavroidis and colleagues recently published a study in Theranostics

[Περισσότερα]

Regulatory T cell transcriptomic reprogramming characterizes adverse events by checkpoint inhibitors in solid tumors

Panayotis Verginis, Themis Alissafi and colleagues recently published a study in Cancer Immunology Research

[Περισσότερα]

A Novel SNCA A30G Mutation Causes Familial Parkinson's Disease

Leonidas Stefanis and colleagues recently published a paper in Movement Disorders

[Περισσότερα]

A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord

Dimitris Beis, Vasiliki Tsata and colleagues recently published a manuscript in Developmental Cell

[Περισσότερα]

2020

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Δημοσίευση του Ευάγγελου Ανδρεάκου και συνεργατών στο Nature Immunology

[Περισσότερα]

Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats

Leonidas Stefanis, Alexia Polissidis and colleagues recently published a study in Movement Disorders

[Περισσότερα]

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Panayotis Verginis and colleagues recently published a paper in Cell

[Περισσότερα]

Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes

Dimitris Thanos, Marios Agelopoulos and colleagues recently published a study in the EMBO Journal

[Περισσότερα]

Gender-specific transcriptional profiles identified in β-thalassemia patients

Eleni Katsantoni and colleagues recently published a paper in Haematologica

[Περισσότερα]

18F-FDG PET/CT brain glucose metabolism as a marker of different types of depression comorbidity in chronic heart failure patients with impaired systolic function

Sofia Chatziioannou and colleagues recently published a paper in European Journal of Heart Failure

[Περισσότερα]

Mitochondrial oxidative damage underlies regulatory T cell defects in autoimmunity

Panayotis Verginis and colleagues recently published a study in Cell Metabolism

[Περισσότερα]

Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α–dependent pathways

Georgina Xanthou and colleagues recently published a study in PNAS

[Περισσότερα]

mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing

Δημοσίευση Πόπης Συντυχάκη, Χρήστου Ζέρβα και συνεργατών τους στο eLife

[Περισσότερα]

Unravelling the effect of the E545K mutation on PI3Ka kinase†

Zoe Cournia and colleagues recently published a paper in Chemical Science

[Περισσότερα]

Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD)

Δημοσίευση της Κάτιας Καραλή και συνεργατών στο Molecular Psychiatry

[Περισσότερα]

Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus

Dimitrios Boumpas and colleagues recently published a study in Annals of the Rheumatic Diseases

[Περισσότερα]

2019

An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion

Panayotis Verginis and colleagues recently published a study in Nature Immunology

[Περισσότερα]

A Deep Learning Framework for Predicting Response to Therapy in Cancer

Vassilis Gorgoulis, Konstantinos Vougas and colleagues recently published a study in Cell Reports

[Περισσότερα]

CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus

Katia Catherine Karalis and Colleagues recently published a study in Cell Reports

[Περισσότερα]

Machine learning and data mining frameworks for predicting drugresponse in cancer: An overview and a novelin silicoscreening processbased on association rule mining

Vassilis G. Gorgoulis, Konstantinos Vougas and colleagues recently published in Pharmacology and Therapeutics

[Περισσότερα]

Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia

Vassilis Gorgoulis and colleagues recently published a study in Nature

[Περισσότερα]

Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity

Dimitris Boumpas and colleagues recently published a study in Annals of the Rheumatic Diseases Journal

[Περισσότερα]

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

Maria Xilouri and colleagues recently published a study in Acta Neuropathologica

[Περισσότερα]

2018

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

Panayotis Verginis, Dimitrios Boumpas and colleagues published a new study in Cell Reports

[Περισσότερα]

Plasmacytoid dendritic cells drive acute asthma exacerbations

Evangelos Andreakos and colleagues recently published a study in JACI

[Περισσότερα]

Senescence and Senotherapeutics: a New Field in Cancer Therapy

Vassilis Gorgoulis and colleagues recently published a paper in Pharmacology & Therapeutics

[Περισσότερα]

The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression

Dimitris Thanos and colleagues recently published a study in Molecular cell

[Περισσότερα]

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

Vassilis Gorgoulis and colleagues recently published a study in Nature Communications

[Περισσότερα]

Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells

Panayotis Verginis and colleagues recently published a study in the Journal of Clinical Investigation

[Περισσότερα]

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Vassilis Gorgoulis and colleagues recently published a study in Genome Biology

[Περισσότερα]

18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomographic Imaging Detects Aortic Wall Inflammation in Patients With Repaired Coarctation of Aorta

Δημοσίευση του Κωνσταντίνου Αναγνωστόπουλου και συνεργατών στο Circulation Cardiovascular Imaging

[Περισσότερα]

Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion

Katia Karalis and colleagues recently published a new study in Cell Reports

[Περισσότερα]

2017

Tregs restrain dendritic cell autophagy to ameliorate autoimmunity

Panayotis Verginis and colleagues recently published a study in JCI

[Περισσότερα]

Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

A new paper by Evangelos Andreakos and colleagues was recently published in Immunity. A commentary followed from the same issue of Immunity, and the article was also featured in Nature Reviews Immunology – Highlights.

[Περισσότερα]

Nurr1:RXRα Heterodimer Activation as Monotherapy for Parkinson’s Disease

Demetrios Vassilatis and colleagues recently published a study in PNAS

[Περισσότερα]

Activin-A co-opts IRF4 and AhR Signaling to Induce Human Regulatory T Cells that Restrain Asthmatic Responses

A new paper by Georgina Xanthou and her colleagues was recently published in PNAS

[Περισσότερα]

Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling

Ioannis Serafimidis and colleagues recently published a paper in PLOS Biology.

[Περισσότερα]

2016

Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication

Ο Σαράντης Γκάκος και οι συνεργάτες του, πρόσφατα δημοσίευσαν μελέτη στο EMBO Reports

[Περισσότερα]

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas

A new study was published in Cell by Vassilis Gorgoulis and colleagues

[Περισσότερα]

The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions

Eleni Katsantoni and colleagues recently published a study in Nucleic Acids Research

[Περισσότερα]

Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats

Leonidas Stefanis, Maria Xilouri and colleagues published a study in Autophagy

[Περισσότερα]

Nuclear receptor NR5A2 controls neural stem cell fate decisions during development

A new paper was recently published online in Nature Communications from the Panagiotis Politis Group

[Περισσότερα]

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Vassilis G. Gorgoulis and colleagues published a study in Nature Cell Biology

[Περισσότερα]

KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis

Apostolos Klinakis and colleagues conducted a study that was published in Nature Communications.

[Περισσότερα]

Genetic Studies in Flies Shed New Light on How Cells Modulate their Adhesion Properties when Exposed to Physical Forces

Christos Zervas and colleagues published a paper in Cell Reports.

[Περισσότερα]

GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum

Kostas Vekrellis and colleagues published a study in Brain.

[Περισσότερα]

2015

Study in the Design of Novel Targeted Molecules for the Treatment of Solid Tumors

Constantin Tamvakopoulos and colleagues published a paper in Cancer Research.

[Περισσότερα]

Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18

Dr Capetanaki and colleagues published a study in Nature Medicine.

[Περισσότερα]

Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene Expression

Dr. Thanos and colleagues published a paper in Cell Reports.

[Περισσότερα]