Biomedical Ίδρυμα Ιατροβιολογικών Ερευνών, Ακαδημίας ΑθηνώνΑκαδημία Αθηνών
Επιστημονικά Επιτεύγματα

2023
Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6- dependent pathways Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6- dependent pathways

Vassilis G. Gorgoulis, Athanasios Tzioufas and collaborators published a research article in Annals of the Rheumatic Diseases (ARD)

[Περισσότερα]

A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells

Vassilis G. Gorgoulis and collaborators published a research article in Molecular Cell

[Περισσότερα]

A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer

Vassilis Gorgoulis and collaborators have recently published a paper in the Journal of Experimental & Clinical Cancer Research

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Novel H2S-Releasing Bifunctional Antihistamine Molecules with Improved Antipruritic and Reduced Sedative Actions Novel H2S-Releasing Bifunctional Antihistamine Molecules with Improved Antipruritic and Reduced Sedative Actions

Andreas Papapetropoulos and colleagues recently published a paper in the Journal of Medicinal Chemistry

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HGCA2.0: An RNA-Seq Based Webtool for Gene Coexpression Analysis in Homo sapiens HGCA2.0: An RNA-Seq Based Webtool for Gene Coexpression Analysis in Homo sapiens

Ioannis Michalopoulos and colleagues recently published a study in Cells

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2022
ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus

Dimitrios Boumpas, Panayotis Verginis and their colleagues recently published a study in Sciences Advances

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Predicting protein–membrane interfaces of peripheral membrane proteins using ensemble machine learning Predicting protein–membrane interfaces of peripheral membrane proteins using ensemble machine learning

Alexios Chatzigoulas and Zoe Cournia recently published a study in Briefings in Bioinformatics

[Περισσότερα]

An integrin axis induces IFN-β production in plasmacytoid dendritic cells An integrin axis induces IFN-β production in plasmacytoid dendritic cells

Evangelia Kourepini, Nikolaos Paschalidis and Davina Simoes - members of the Cellular Immunology Laboratory of Vily Panoutsakopoulou - published a study in the Journal of Cell Biology

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Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication

Paschalis Sideras, Athanasios Stavropoulos and colleagues recently published a study in Science Signaling

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MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity

Andreas Papapetropoulos, Antonia Katsouda and Colleagues Recently Published a Study in JEM

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Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model

Stelios Psarras and his colleagues recently published a study in Cellular and Molecular Life Sciences Journal

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Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2 Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2

Vassilis G. Gorgoulis and collaborators published a research article in the Computational and Structural Biotechnology Journal

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TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthma TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthma

Georgina Xanthou and her colleagues recently published a study in Allergy

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Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine

Constantin Tamvakopoulos and colleagues recently published a study in the Journal of Medicinal Chemistry

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2021
RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1 RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1

Vassilis G. Gorgoulis and colleagues recently published a study in EMBO Reports

[Περισσότερα]

Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK

Despina Sanoudou and colleagues recently published a paper in Metabolism - Clinical and Experimental

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The effect of S427F mutation on RXRα activity depends on its dimeric partner The effect of S427F mutation on RXRα activity depends on its dimeric partner

Apostolos Klinakis, Zoe Cournia and colleagues recently published a study in Chemical Science

[Περισσότερα]

N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains. N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains.

Theodoros Rampias, Apostolos Klinakis and Zoe Cournia recently published a study in Computational and Structural Biotechnology Journal

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Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung

Maria Semitekolou, Georgina Xanthou and colleagues recently published a paper in Journal of Experimental and Clinical Cancer Research

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Prox1 inhibits neurite outgrowth during central nervous system development Prox1 inhibits neurite outgrowth during central nervous system development

Panagiotis Politis, Valeria Kaltezioti and colleagues recently published a study in Cellular and Molecular Life Sciences

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Regulatory T cell transcriptomic reprogramming characterizes adverse events by checkpoint inhibitors in solid tumors Regulatory T cell transcriptomic reprogramming characterizes adverse events by checkpoint inhibitors in solid tumors

Panayotis Verginis, Themis Alissafi and colleagues recently published a study in Cancer Immunology Research

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A Novel SNCA A30G Mutation Causes Familial Parkinson's Disease A Novel SNCA A30G Mutation Causes Familial Parkinson's Disease

Leonidas Stefanis and colleagues recently published a paper in Movement Disorders

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2020
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Δημοσίευση του Ευάγγελου Ανδρεάκου και συνεργατών στο Nature Immunology

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Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats

Leonidas Stefanis, Alexia Polissidis and colleagues recently published a study in Movement Disorders

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Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Panayotis Verginis and colleagues recently published a paper in Cell

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Gender-specific transcriptional profiles identified in β-thalassemia patients Gender-specific transcriptional profiles identified in β-thalassemia patients

Eleni Katsantoni and colleagues recently published a paper in Haematologica

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Mitochondrial oxidative damage underlies regulatory T cell defects in autoimmunity Mitochondrial oxidative damage underlies regulatory T cell defects in autoimmunity

Panayotis Verginis and colleagues recently published a study in Cell Metabolism

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mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing

Δημοσίευση Πόπης Συντυχάκη, Χρήστου Ζέρβα και συνεργατών τους στο eLife

[Περισσότερα]

Unravelling the effect of the E545K mutation on PI3Ka kinase† Unravelling the effect of the E545K mutation on PI3Ka kinase†

Zoe Cournia and colleagues recently published a paper in Chemical Science

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Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD) Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD)

Δημοσίευση της Κάτιας Καραλή και συνεργατών στο Molecular Psychiatry

[Περισσότερα]

Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus

Dimitrios Boumpas and colleagues recently published a study in Annals of the Rheumatic Diseases

[Περισσότερα]

2019
An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion

Panayotis Verginis and colleagues recently published a study in Nature Immunology

[Περισσότερα]

A Deep Learning Framework for Predicting Response to Therapy in Cancer A Deep Learning Framework for Predicting Response to Therapy in Cancer

Vassilis Gorgoulis, Konstantinos Vougas and colleagues recently published a study in Cell Reports

[Περισσότερα]

CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus

Katia Catherine Karalis and Colleagues recently published a study in Cell Reports

[Περισσότερα]

Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia

Vassilis Gorgoulis and colleagues recently published a study in Nature

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Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity

Dimitris Boumpas and colleagues recently published a study in Annals of the Rheumatic Diseases Journal

[Περισσότερα]

2018
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

Panayotis Verginis, Dimitrios Boumpas and colleagues published a new study in Cell Reports

[Περισσότερα]

Plasmacytoid dendritic cells drive acute asthma exacerbations Plasmacytoid dendritic cells drive acute asthma exacerbations

Evangelos Andreakos and colleagues recently published a study in JACI

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Senescence and Senotherapeutics: a New Field in Cancer Therapy Senescence and Senotherapeutics: a New Field in Cancer Therapy

Vassilis Gorgoulis and colleagues recently published a paper in Pharmacology & Therapeutics

[Περισσότερα]

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

Vassilis Gorgoulis and colleagues recently published a study in Nature Communications

[Περισσότερα]

Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells

Panayotis Verginis and colleagues recently published a study in the Journal of Clinical Investigation

[Περισσότερα]

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Vassilis Gorgoulis and colleagues recently published a study in Genome Biology

[Περισσότερα]

18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomographic Imaging Detects Aortic Wall Inflammation in Patients With Repaired Coarctation of Aorta 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomographic Imaging Detects Aortic Wall Inflammation in Patients With Repaired Coarctation of Aorta

Δημοσίευση του Κωνσταντίνου Αναγνωστόπουλου και συνεργατών στο Circulation Cardiovascular Imaging

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2017
Tregs restrain dendritic cell autophagy to ameliorate autoimmunity Tregs restrain dendritic cell autophagy to ameliorate autoimmunity

Panayotis Verginis and colleagues recently published a study in JCI

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Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

A new paper by Evangelos Andreakos and colleagues was recently published in Immunity. A commentary followed from the same issue of Immunity, and the article was also featured in Nature Reviews Immunology – Highlights.

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Nurr1:RXRα Heterodimer Activation as Monotherapy for Parkinson’s Disease Nurr1:RXRα Heterodimer Activation as Monotherapy for Parkinson’s Disease

Demetrios Vassilatis and colleagues recently published a study in PNAS

[Περισσότερα]

Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling

Ioannis Serafimidis and colleagues recently published a paper in PLOS Biology.

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2016
Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication

Ο Σαράντης Γκάκος και οι συνεργάτες του, πρόσφατα δημοσίευσαν μελέτη στο EMBO Reports

[Περισσότερα]

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas

A new study was published in Cell by Vassilis Gorgoulis and colleagues

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Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats

Leonidas Stefanis, Maria Xilouri and colleagues published a study in Autophagy

[Περισσότερα]

Nuclear receptor NR5A2 controls neural stem cell fate decisions during development Nuclear receptor NR5A2 controls neural stem cell fate decisions during development

A new paper was recently published online in Nature Communications from the Panagiotis Politis Group

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KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis

Apostolos Klinakis and colleagues conducted a study that was published in Nature Communications.

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