Vassilis G. Gorgoulis, Athanasios Tzioufas and collaborators published a research article in Annals of the Rheumatic Diseases (ARD)

The authors investigated a potentially pathogenic role of cellular senescence in the context of Giant Cell Artiritis (GCA), an age-related, autoinflammatory and autoimmune syndrome. The authors identified a high proportion of senescent cells (mainly fibroblasts and macrophages) with an inflammatory phenotype in GCA arteries. The presence of senescent cells was associated with the tissue inflammatory bulk via IL-6-dependent pathways, suggesting a potential implication of senescence in disease pathogenesis. These results set the ground for the use of senolytic treatments as a possible complementary strategy in the clinical management of GCA.

pubmed

Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways.
Veroutis D, Argyropoulou OD, Goules AV, Kambas K, Palamidas DA, Evangelou K, Havaki S, Polyzou A, Valakos D, Xingi E, Karatza E, Boki KA, Cavazza A, Kittas C, Thanos D, Ricordi C, Marvisi C, Muratore F, Galli E, Croci S, Salvarani C, Gorgoulis VG, Tzioufas AG.
Ann Rheum Dis. 2023 Nov 24:ard-2023-224467. doi: 10.1136/ard-2023-224467.