Professor Vassilis Gorgoulis and collaborators have recently published a paper in Aging Cell showing that major genome translation deregulation mechanisms occur during cellular senescence, but at different rates depending on the type of the stimulus. Naturally occurring replicative senescence is not accompanied by increased incidence of such mechanisms. However, stress-induced senescence, and at a much greater extent, oncogene-induced senescence, are characterised by distinct sets of translation deregulation patterns. This work additionally provides an explanation for lipofuscin accumulation, a hallmark of senescent cells.

Pubmed

Decoding of translation-regulating entities reveals heterogeneous translation deficiency patterns in cellular senescence.
Papaspyropoulos A, Hazapis O, Altulea A, Polyzou A, Verginis P, Evangelou K, Fousteri M, Papantonis A, Demaria M, Gorgoulis V. Aging Cell. 2023 Aug 7:e13893. doi: 10.1111/acel.13893. Online ahead of print. PMID: 37547972 Free article.