A new paper was recently published online in Nucleic Acids Research from the Katsantoni Group at BRFAA. In this study, the authors deciphered mechanisms of transcriptional activation and repression, mediated by the Signal Transducer and Activator of Transcription 5 (STAT5). STATs are latent cytoplasmic transcription factors that transduce signals from activated cell surface receptors to the nucleus to modulate transcription. STAT5a and STAT5b are of particular interest as they are constitutively activated in various hematopoietic and solid malignancies.
The researchers in Katsantoni Group applied genomics, proteomics and bioinformatics approaches to elucidate mechanisms of STAT5-dependent transcriptional regulation and showed that LSD1 and HDAC3 play a dual role in STAT5-dependent transcription. This dual role was determined by the protein-protein interactions, the binding affinities, the underlying motifs and the genomic positions of binding.
The novel insights on STAT5-dependent transcriptional mechanisms provided in this paper form a platform for the complete delineation of STAT5 interactions-target genes’ networks in normal and malignant cells.
Nanou A, Toumpeki C, Lavigne MD, Lazou V, Demmers J, Paparountas T, Thanos D, Katsantoni E.
The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions.
Nucleic Acids Res. 2016 Sep 19. pii: gkw832. [Epub ahead of print]