Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Costis Costis Papanayotou, PhD
Researcher D'

Telephone : +30 210 6597 199
e-mail :

Center :

Basic Research

Lab Site :

Papanayotou Lab

Brief Bio

Costis Papanayotou graduated from the Biology Department of the University of Athens. He did his PhD thesis in the Department of Genetics and Development of Columbia University in New York, in Pr Claudio Stern’s laboratory, on the transcriptional regulation of neural genes during neural induction of the chick embryo. After having been awarded his doctorate, he followed Pr Stern in University College London, where he studied the role of calcium in neural induction. He subsequently joined Dr Jérôme Collignon’s laboratory in Institut Jacques Monod in Paris, where he studied in the mouse embryo the epigenetic regulation by pluripotency transcription factors of Nodal, a gene required for the early embryonic development of vertebrates. In 2016 he was appointed Researcher D’ in the Center for Basic Research of the Biomedical Research Foundation Academy of Athens. His interests include the study of embryonic stem cells and their potential applications.

Selected Publications

Papanayotou C, Collignon J. (2014). Activin/Nodal signalling before implantation: setting the stage for embryo patterning. Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657). pii: 20130539. doi: 10.1098/rstb.2013.0539.

Cajal M, Creuzet SE, Papanayotou C, Sabéran-Djoneidi D, Chuva de Sousa Lopes SM, Zwijsen A, Collignon J, Camus A. (2014). A conserved role for non-neural ectoderm cells in early neural development. Development. 2014 Nov;141(21):4127-38. doi: 10.1242/dev.107425. Epub 2014 Oct 1.

Papanayotou C, Benhaddou A, Camus A, Perea-Gomez A, Jouneau A, Mezger V, Langa F, Ott S, Sabéran-Djoneidi D, Collignon J. (2014). A novel Nodal enhancer dependent on pluripotency factors and Smad2/3 signaling conditions a regulatory switch during epiblast maturation. PLoS Biol. 2014 Jun 24;12(6):e1001890. doi: 10.1371/journal.pbio.1001890. eCollection 2014 Jun.

Jego G, Lanneau D, De Thonel A, Berthenet K, Hazoumé A, Droin N, Hamman A, Girodon F, Bellaye PS, Wettstein G, Jacquel A, Duplomb L, Le Mouël A, Papanayotou C, Christians E, Bonniaud P, Lallemand-Mezger V, Solary E, Garrido C. (2014). Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes. Leukemia. 2014 Aug;28(8):1676-86. doi: 10.1038/leu.2014.63. Epub 2014 Feb 7.

Papanayotou C, De Almeida I, Liao P, Oliveira NM, Lu SQ, Kougioumtzidou E, Zhu L, Shaw A, Sheng G, Streit A, Yu D, Wah Soong T, Stern CD. (2013). Calfacilitin is a calcium channel modulator essential for initiation of neural plate development. Nat Commun. 2013;4:1837. doi: 10.1038/ncomms2864.

Granier C, Gurchenkov V, Perea-Gomez A, Camus A, Ott S, Papanayotou C, Iranzo J, Moreau A, Reid J, Koentges G, Sabéran-Djoneidi D, Collignon J. (2011). Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo. Dev Biol. 2011 Jan 15;349(2):350-62. doi: 10.1016/j.ydbio.2010.10.036. Epub 2010 Nov 1.

Linker C, De Almeida I, Papanayotou C, Stower M, Sabado V, Ghorani E, Streit A, Mayor R, Stern CD. (2009). Cell communication with the neural plate is required for induction of neural markers by BMP inhibition: evidence for homeogenetic induction and implications for Xenopus animal cap and chick explant assays. Dev Biol. 2009 Mar 15;327(2):478-86. doi: 10.1016/j.ydbio.2008.12.034. Epub 2009 Jan 3.

Voiculescu O, Papanayotou C, Stern CD. (2008). Spatially and temporally controlled electroporation of early chick embryos. Nat Protoc. 2008;3(3):419-26. doi: 10.1038/nprot.2008.10.

Papanayotou C, Mey A, Birot AM, Saka Y, Boast S, Smith JC, Samarut J, Stern CD. (2008). A mechanism regulating the onset of Sox2 expression in the embryonic neural plate. PLoS Biol. 2008 Jan;6(1):e2. doi: 10.1371/journal.pbio.0060002.

Streit A, Berliner AJ, Papanayotou C, Sirulnik A, Stern CD. (2000). Initiation of neural induction by FGF signalling before gastrulation. Nature. 2000 Jul 6;406(6791):74-8.


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