Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Aristotelis Aristotelis Chatziioannou, PhD
Researcher A'

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Systems Biology

Brief Bio

Dr Aristotelis Chatziioannou holds a Diploma from the School of Electrical and Computer Engineering of the National Technical University of Athens (NTUA), since 1996. After working as an Engineer in Industrial Consulting in Germany (IAS Mannheim) with emphasis in the optimization of maintenance tasks in plant production lines, he begun his postgraduate studies in the School of Chemical Engineering, NTUA in 2001, earning his PhD in Metabolic Engineering and Bioinformatics in July 2005. From 2004 till September 2005, worked in parallel as a postdoctoral fellow in BSRC Alexander Fleming, Vari Greece, where he developed the first computational pipeline for multi-layered transcriptomic analysis in Greece to support the interpretation of the microarray facility of the center. In February 2006 he was appointed Research Lecturer and Group Leaded of the newly found Metabolic Engineering and Bioinformatics Group of the Institute of Biological Research & Biotachnology of the National Hellenic Research Foundation, Athens, where he served till June 2020 having being promoted to Assistant Professor (2009) and Associate Professor (2013) during his tenure. Since July 2020 serves as Investigator (Professor) at the Center of Systems Biology of  the Biomedical Research Foundation of the Academy of Athens. AC has been particularly active in the field of technological innovation, being the cofounder and CEO of e-NIOS Applications PC, a spin-out SME, in the area of intelligent Big Data analysis of complex biological data. His research interests include In-Silico (virtual modeling and algorithmic development) Systems Biology, Knowledge-Mining and Cognitive Computing in Life sciences, Big Data and Artificial Intelligence in Biomedicine, Biostatistics, Metabolic Engineering, and Biomedical Image Processing. He has served as Invited Professor during 2012-2013, for CNRS and INSERM at Bordeaux, France, in the area of Bioinformatics and Systems Biology. He has authored or coauthored more than 250 journal and international conference papers in these fields (h-index: 23, i-10 index:44 source Google Scholar). He has supervised 21 Phd Thesis and 18 Diploma projects He has participated in a coordinating role, in more than 20 European and National Research Grants, (7 through e-NIOS Applications PC). He has also actively contributed in the strategic planning of research policies and their harmonization with the European and International Framework as Vice President of the Hellenic Union of Researchers (2 tenures, 2009-2015), and two tenures in the Board (Vice President) of the NHRF Personnel Association. He has been member of the Panel of Experts of the Hellenic National Committee of Research and Innovation (2016-2017) with the mission to elaborate a National Roadmap for Research and Innovation in Greece and Substitute member at the Board of the Hellenic State Foundation of Scholarships till July 2020. During 2018-2019 he served as member of the Board of GR-NET, the Hellenic National Infrastructure for Scientific /Tech Computing. At present, he serves as Treasurer of the Administrative Board of the Hellenic Society of Computational Biology and Bioinformatics and as Deputy Technical Coordinator and Deputy Tools Platform Coordinator in the Hellenic Node of ELIXIR (ELIXIR-GR).

Selected Publications

Camila Rubio-Patiño, Jozef P Bossowski, Gian Marco De Donatis, Laura Mondragón, Elodie Villa, Lazaro E Aira, Johanna Chiche, Rana Mhaidly, Cynthia Lebeaupin, Sandrine Marchetti, Konstantinos Voutetakis, Aristotelis Chatziioannou, Florence A Castelli, Patricia Lamourette, Emeline Chu-Van, François Fenaille, Tony Avril, Thierry Passeron, John B Patterson, Els Verhoeyen, Béatrice Bailly-Maitre, Eric Chevet, Jean-Ehrland Ricci. Low-protein diet induces IRE1α-dependent anticancer immunosurveillance. Cell Metabolism, 2018, 27 (4), 828-842. e7

Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, Raphaël Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, Gwénaële Jégou, Néstor Pallares‐Lupon, Kathleen Schmit, Pierre‐Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie Vauléon, Marion Maurel, Afshin Samali, John B Patterson, Olivier Pluquet, Claudio Hetz, Véronique Quillien, Aristotelis Chatziioannou, Eric Chevet. Dual IRE 1 RN ase functions dictate glioblastoma development. EMBO Molecular Medicine, 2018, e7929.

Eric Chevet, Aristotelis Chatziioannou. Method of selection of an ire1-inhibitor therapy for patient suffering from cancer. US Patent App 2020, 16955989

M. Maurel, T. Avril, Y. Ding, J. Obacz, O. Papadodima, X. Treton, E. Pilalis, D. Cazals-Hatem, T. Hupp, L., R. Hrstka., J. Tavernier, D. Fessart, F. Delom, A. Samali, A. Chatziioannou+, E. Chevet+, E, Ogier-Denis+. Control of anterior GR adient 2 (AGR 2) dimerization links endoplasmic reticulum proteostasis to inflammation. EMBO Molecular Medicine 2019, e10120

Ludmila Cardoso Alves, Michael D Berger, Thodoris Koutsandreas, Nick Kirschke, Christoph Lauer, Roman Spörri, Aristotelis Chatziioannou, Nadia Corazza, Philippe Krebs. Non‐apoptotic TRAIL function modulates NK cell activity during viral infection. EMBO reports, 2020, 21(1), e48789.

Daria Sicari, Aristotelis Chatziioannou, Theodoros Koutsandreas, Roberto Sitia, Eric Chevet. Role of the early secretory pathway in SARS-CoV-2 infection. Journal of Cell Biology, 2020, 219(9), (

Verona Buocikova, Ivan Rios-Mondragon, Eleftherios Pilalis, Aristotelis Chatziioannou, Svetlana Miklikova, Michal Mego, Karlis Pajuste, Martins Rucins, Naouale El Yamani, Eleonora Marta Longhin, Arkadij Sobolev, Muriel Freixanet, Victor Puntes, Aiva Plotniece, Maria Dusinska, Mihaela Roxana Cimpan, Alena Gabelova, Bozena Smolkova. Epigenetics in Breast Cancer Therapy—New Strategies and Future Nanomedicine Perspectives. Cancers, 2020, 12 (12), 3622.

Th. Koutsandreas, E. Ladoukakis, E. Pilalis, D. Zarafeta, G. Skretas, A. Krogh, F. Kolisis, A. Chatziioannou. ANASTASIA: an automated metagenomic analysis pipeline for novel enzyme discovery exploiting next generation sequencing data. Frontiers in Genetics, 2019, 10, 469

HX de Lastic, I Liampa, A G Georgakilas, M Zervakis, A Chatziioannou. Entropic Ranks: A Methodology for Enhanced, Threshold-Free, Information-Rich Data Partition and Interpretation. Applied Sciences, 2020, 10 (20), 7077.

G Kontogianni, G Piroti, I Maglogiannis, A Chatziioannou, O Papadodima. Dissecting the mutational landscape of cutaneous melanoma: an Omic analysis based on patients from Greece. Cancers, 2018, 10 (4), 96.

Paolo Vineis, Aristotelis Chatziioannou, Vincent T Cunliffe, James M Flanagan, Mark Hanson, Micheline Kirsch‐Volders, Soterios Kyrtopoulos. Epigenetic memory in response to environmental stressors. FASEB Journal, 2017, 31 (6), 2241-2251

Efstathios–Iason Vlachavas, Eleftherios Pilalis, Olga Papadodima, Dirk Koczan, Stefan Willis, Sven Klippel, Caixia Cheng, Leyun Pan, Christos Sachpekidis, Alexandros Pintzas, Vasilis Gregoriou, Antonia Dimitrakopoulou-Strauss, Aristotelis Chatziioannou. Radiogenomic analysis of F-18-fluorodeoxyglucose positron emission tomography and gene expression data elucidates the epidemiological complexity of colorectal cancer landscape. CSBJ 2019, 17, 177-185,


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