Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Evangelia Evangelia Charmandari, MD, MSc, PhD, MRCP(UK), CCST(UK)
University Faculty, Affiliated Investigator

Telephone : +30 210 6597 196
Fax : +30 210 6597 545
e-mail : echarman@bioacademy.gr


Center :

Clinical, Experimental Surgery & Translational Research

Lab Site :

Chrousos & Charmandari Lab


Brief Bio

Dr. Charmandari graduated from the Medical School of the University of Thessaloniki as a valedictorian of her class (highest distinction) in 1988, and completed her specialization in Pediatrics in the UK. She was further subspecialized in Pediatric and Adolescent Endocrinology at the London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children, and University College Hospital in London (UK). Dr. Charmandari is a certified Pediatrician and Pediatric and Adolescent Endocrinologist by the Royal College of Pediatrics and Child Health, London, UK. She obtained a Master of Science in Clinical Pediatrics and a PhD in Pediatric and Adolescent Endocrinology, which were awarded by the University of London (UK) in 1998 and 2001, respectively. She subsequently undertook a Postdoctoral fellowship in Molecular Endocrinology and Cellular Biology at the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. She also worked as a Consultant in Pediatric and Adolescent Endocrinology at St. James' University Hospital and Leeds General Infirmary, Leeds, UK (2006-2007).

Following 15 years of clinical and research (basic, clinical and translational) work in the UK and USA, Dr. Charmandari returned back to Greece having been awarded a European Union reintegration grant. She used this opportunity to establish and develop the Laboratory of the Division of Endocrinology and Metabolism at the Biomedical Research Foundation of the Academy of Athens.

Since February 2011, Dr. Charmandari is an Associate Professor of Pediatric and Adolescent Endocrinology at the Medical School of the National and Kapodistrian University of Athens. She carries out her clinical and research work at the Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, "Aghia Sophia" Hospital for Children.

Dr. Charmandari is a member of the Royal College of Physicians (MRCP), since 1996, and holds the Certificate of Completion of Specialist Training in General Paediatrics as well as Paediatric Endocrinology (CCST) since 2005. She is an Affiliated Investigator of the Biomedical Research Foundation of the Academy of Athens as well as a member of the British Society for Paediatric Endocrinology and Diabetes, the Society for Endocrinology, The Endocrine Society, and the Medical Association of Athens. In 2007 she was awarded the "Henning Andersen Prize" of the European Society of Paediatric Endocrinology for her research.

She has published over 60 papers in refereed journals, which have received more than 1500 citations (h-index=22, Impact Factor: 300), as well as 1 book, 30 chapters in textbooks and electronic journals, and 75 abstracts in conference proceedings. A complete list of her refereed papers is available in the PubMed, while her ResearcherID is B-6701-2011.

Selected Publications

Charmandari E. Primary generalized glucocorticoid resistance and hypersensitivity: the end-organ involvement in the stress response. Science Signaling 2012;  [Epub ahead of print]

Charmandari E, Sertedaki A, Kino T, Merakou C, Hoffman DA, Hatch MM, Hurt DE, Lin L, Xekouki P, Stratakis CA, Chrousos GP. A Novel Point Mutation in the KCNJ5 Gene Causing Primary Hyperaldosteronism and Early-Onset Autosomal Dominant Hypertension. Journal of Clinical Endocrinology & Metabolism 2012; 97(8): E1532-9.

Charmandari E, Chrousos GP, Lambrou GI, Pavlaki A, Koide H, Ng SSM, Kino T. Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man. PLoS One 2011; 6(9): e25612.

Galata Z, Moschonis G, Makridakis M, Dimitraki P, Nicolaides N, Manios Y, Bartzeliotou A, Chrousos GP, Charmandari E. Plasma proteomic analysis in overweight and obese children. European Journal of Clinical Investigation 2011; 41(12): 1275-83.

Nicolaides N, Galata Z, Chrousos GP, Charmandari E. The glucocorticoid receptor: Evolution, structure and molecular basis of biologic function. Steroids 2010; 75(1): 1-12.

Kino T, Ichijo T, Zachman K, Chrousos GP, Charmandari E. A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression. Journal of Clinical Endocrinology & Metabolism 2008; 93(12): 4963-8.

Charmandari E, Kino T, Ichijo T, Chrousos GP. Generalized Glucocorticoid Resistance: Clinical Aspects, Molecular Mechanisms and Implications of a Rare Genetic Disorder. Journal of Clinical Endocrinology & Metabolism 2008; 93(5): 1563-72.

Kino T, Souvatzoglou E, Charmandari E, Ichijo T, Driggers P, Mayers C, Alatsatianos A, Manoli I, Westphal H, Chrousos GP, Segars JH. RHO family guanine nucleotide exchange factor BRX couples extracellular signals to the glucocorticoid signaling system. Journal of Biological Chemistry 2006; 281(14): 9118-9126.

Charmandari E, Raji A, Kino T, Ichijo T, Tiulpakov A, Zachman K, Chrousos GP. A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: The importance of C-terminus of hGR LBD in conferring transactivational activity. Journal of Clinical Endocrinology & Metabolism 2005; 90(6): 3696-3705.

Charmandari E, Tsigos C, Chrousos GP. Endocrinology of the stress response. Annual Reviews of Physiology 2005; 67: 259-284.

Charmandari E, Chrousos GP, Ichijo T, Bhattacharyya N, Vottero A, Souvatzoglou E, Kino T. The human glucocorticoid receptor (GR) β isoform suppresses the transcriptional activity of GRα by interfering with formation of active coactivator complexes. Molecular Endocrinology 2005; 19(1): 52-64.

Charmandari E, Merke DP, Negro PJ, Keil MF, Martinez PE, Haim A, Gold PW, Chrousos GP. Endocrinologic and psychologic evaluation of 21-hydroxylase deficiency carriers and matched normal subjects: evidence for physical and/or psychologic vulnerability to stress. Journal of Clinical Endocrinology & Metabolism 2004; 89(5): 2228-2236.

PubMed:

PubMed Link