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Our lab studies the physiology and pathophysiology of the hypothalamic-pituitary-adrenal (HPA) and gonadal (HPG) axes and the autonomic nervous system, as they relate to each other, and as they influence growth, development, metabolic and immune functions. Both the developmental and static functions of these neurohormonal systems are studied at the integrated level in health and disease. Also, the cellular/subcellular and genomic actions of the key effector molecules of these systems, including corticotropin-releasing hormone (CRH), arginine-vasopressin (AVP), corticotropin (ACTH), glucocorticoids, mineralocorticoids, gonadotropins, estrogens, progestins, androgens and catecholamines, are studied as they relate to normal physiology and disease-related pathophysiology.
Research projects focus on the delineation of the molecular mechanisms of endocrine and metabolic disorders.
Research Projects and Groups:
| 1. | Molecular mechanisms of glucocorticoid signaling in health and disease (Evangelia Charmandari, George P. Chrousos) |
| 2. | Neurohormonal and immune mechanisms of implantation (Emmanuil Zoumakis, George P. Chrousos) |
| 3. | Differentiation and function of adipocytes (Emmanuil Zoumakis, George P. Chrousos) |
| 4. | Interactions between nuclear receptor and G-protein signaling system (Marina Doufexis, George P. Chrousos) |
| 5. | Molecular studies of cholesterol metabolism in health and disease (Athina Samara, George P. Chrousos) |
| 6. | Genetic, epigenetic and evolutionary study of nuclear receptors (Dimitrios Vlachakis, George P Chrousos) |
| 7. | Multiscale computational models for evolutionary and developmental biology (evo-devo) (Dimitrios Vlachakis, George P Chrousos) |
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4 Soranou Ephessiou St., 115 27 Athens, Greece
Tel: +30 210 6597000 | Fax: +30 210 6597545