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Dr. Sarantis Gagos got his bachelor degree in Biology from the University of Patras, Greece. He received his PhD in Cancer Cytogenetics from Athens Medical School, National and Kapodistrian University of Athens, Greece, in 1993. The same year, he was appointed Postdoctoral Research Fellow at the Laboratory of Cellular Genetics, M.D. Anderson Cancer Center, University of Texas, Houston, USA (Directors: T.C. Hsu, S. Pathak). In 1994, he joined the Kleberg Cytogenetic and Prenatal Diagnosis Laboratory at the Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, USA (Director: L.G. Shaffer). Dr. Gagos was enrolled in Baylor’s postdoctoral training program for the American Board of Medical Genetics (Director A. Beaudet). Dr Gagos was certified by the American Board of Medical Specialties in 1996, as a “Clinical Cytogeneticist”. Sarantis Gagos was the first researcher to join BRFAA in 1998, as Investigator level D. In 2002, he was promoted to Investigator C (Assistant Professor), and took a 12-month sabbatical to the Division of Medical Genetics, University of Geneva Medical School, Switzerland (Director: S.E. Antonarakis). In 2003, Dr. Gagos was appointed Associate Director of the Laboratories of Clinical Cytogenetics and Molecular Diagnostics in the Division of Medical Genetics of the University Hospital of Geneva. Dr. Gagos returned to BRFAA in 2004, as a Primary Investigator. From 2014 he was promoted to Principal Investigator (Associate Professor). In 2016, Dr. Gagos was certified as a “Clinical Laboratory Geneticist” by the European Board of Medical Genetics. From 2012, Gagos group provides specialized clinical and research cytogenetic services at BRFAA. Current research of Gagos group is focused on chromosomal instability and the basic mechanisms involved in recombinatorial telomere maintenance in fertility, development, ageing and cancer.
Roumelioti FM, Sotiriou SK, Katsini V, Chiourea M, Halazonetis TD, Gagos S. (2016): Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication. EMBO Reports ;17(12):1731-1737.
Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG (2016).: Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nature Cell Biology; 18(7):777-789.
Marzec P, Armenise C, Pérot G, Roumelioti FM, Basyuk E, Gagos S, Chibon F, Déjardin J (2015): Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers. Cell 160(5):913-927.
Dan J, Liu N, Liu Y, Chiourea M, Okuka M, Wu T, Mou C, Wang L, Wang L,Yin Y, Yuan J, Zuo B, Wang F, Zhang Q, Ye X, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A, and Liu L (2014): Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Developmental Cell 29(1):7-19.
Sakellariou D, Chiourea M, Raftopoulou C, Gagos S (2013): Alternative Lengthening of Telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction. Neoplasia 15(11):1301-1313.
Christodoulidou A, Raftopoulou C, Chiourea M, Papaioannou GK, Hoshiyama H, Wright WE, Shay JW, Gagos S. (2013): The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth. Neoplasia. 15(2):156-68.
Kohzaki M, Chiourea M, Versini G, Adachi N, Takeda S, Gagos S, Halazonetis TD (2012): The C-terminus of RecQL4 facilitates DNA replication after exposure to ionizing radiation. Carcinogenesis 33(6):1203-10.
Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L. (2012): Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Research 22(4):757-68.
Sideridou M, Zakopoulou R, Evangelou K, Liontos M, Kotsinas A, Rampakakis, Gagos S, Kahata K, Grabusic K, Gkouskou K, Trougakos I, Kolettas E, Georgakilas A, Volarevic S, Eliopoulos A, Zannis-Hadjopoulos M, Moustakas A and Gorgoulis V (2011): Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. Journal of Cell Biology 195(7):1123-40.
Chawla R, Redon S, Raftopoulou C, Wischnewski H, Gagos S, Azzalin C (2011): Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication through its ATPase activity. The EMBO Journal 30(19):4047-58.
Ryser S, Dizin E, Jefford C-E, Delaval B, Gagos S, Christodoulidou A, Krause K-H, Birnbaum D, Irminger-Finger I (2009): Distinct Roles of BRCA1-Associated Ring Domain Protein 1(BARD1) Isoforms in Mitosis: Full-Length BARD1 Mediates Aurora B Degradation, Cancer-Associated BARD1B Scaffolds Aurora B and BRCA2. Cancer Research 69(3):1125-34.
Gagos S, Chiourea M, Christodoulidou A, Apostolou E, Raftopoulou C, Deustch S, Jefford CE, Irminger-Finger I, Shay JW, Antonarakis SE. (2008): Pericentromeric instability and spontaneous emergence of human neoacrocentric and minute chromosomes in the alternative pathway of telomere lengthening. Cancer Research 68:8146-55.