Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Despina Despina Sanoudou, PhD, FACMG
University Faculty, Affiliated Investigator

Telephone : +30 210 6597 055
Fax : +30 210 6597 545
e-mail : dsanoudou@bioacademy.gr


Center :

Basic Research

Lab Site :

Kranias & Sanoudou Lab


Brief Bio

Dr Despina Sanoudou is a Collaborating Scientist at BRFAA and an Assistant Professor at the Pharmacology Department- Medical School, University of Athens. She studied Molecular Biology, obtained a PhD at the University of Cambridge, got certified in Clinical Molecular Diagnostics (American Board of Medical Genetics), and became an Instructor at the Harvard Medical School. Her research team focuses on the discovery of novel diagnostic and prognostic markers, the identification of novel therapeutic targets, and the evaluation of chemical compounds against cardiovascular diseases. The results of this work have been published in over 70 scientific articles and book chapters, 145 oral and 175 written presentations in scientific meetings worldwide. She serves as an evaluator of research grant applications at the European Commission and other international organizations, as an Editorial Board member of 12 publishers, and as a reviewer in 26 scientific journals. Furthermore, she teaches at 9 MSc programs and has founded the BRFAA High School Outreach Program, which has hosted 2,000 students to date.

Dr Sanoudou has received a series of awards including the L’Oreal-UNESCO award for Young Women in Science, an American Society of Human Genetics education award, multiple Hellenic Cardiological Society and Greek Society of Pharmacology scientific awards and others.

Selected Publications

Vafiadaki E, Arvanitis DA, Sanoudou D, Kranias EG. Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation. PLoS One. 2013 Nov 14;8(11):e80867. doi: 10.1371/journal.pone.0080867.

Totary-Jain H, Sanoudou D, Ben-Dov IZ, Dautriche CN, Guarnieri P, Marx SO, Tuschl T, Marks AR. Reprogramming of the microRNA transcriptome mediates resistance to rapamycin. J Biol Chem. 2013 Mar 1;288(9):6034-44. doi: 10.1074/jbc.M112.416446.

Psarras S, Mavroidis M, Sanoudou D, Davos CH, Xanthou G, Varela AE, Panoutsakopoulou V, Capetanaki Y. Regulation of adverse remodelling by osteopontin in a genetic heart failure model. Eur Heart J. 2012 Aug;33(15):1954-63.

Qian J, Vafiadaki E, Florea SM, Singh VP, Song W, Lam CK, Wang Y, Yuan Q, Pritchard TJ, Cai W, Haghighi K, Rodriguez P, Wang HS, Sanoudou D, Fan GC, Kranias EG. Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling. Circ Res. 2011 Jun 10;108(12):1429-38. doi: 10.1161/CIRCRESAHA.110.237644.

Wang HS, Arvanitis DA, Dong M, Niklewski PJ, Zhao W, Lam CK, Kranias EG, Sanoudou D. SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts. Physiol Genomics. 2011 Apr 12;43(7):357-64. doi: 10.1152/physiolgenomics.00032.2010.

Luo J, Schumacher M, Scherer A, Sanoudou D, Megherbi D, Davison T, Shi T, Tong W, Shi L, Hong H, Zhao C, Elloumi F, Shi W, Thomas R, Lin S, Tillinghast G, Liu G, Zhou Y, Herman D, Li Y, Deng Y, Fang H, Bushel P, Woods M, Zhang J. A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data. Pharmacogenomics J. 2010 Aug;10(4):278-91. doi: 10.1038/tpj.2010.57.

Sanoudou D, Duka A, Drosatos K, Hayes KC, Zannis VI. Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic mice. Pharmacogenomics J. 2010 Jun;10(3):165-79. doi: 10.1038/tpj.2009.51.

Papalouka V, Arvanitis DA, Vafiadaki E, Mavroidis M, Papadodima SA, Spiliopoulou CA, Kremastinos DT, Kranias EG, Sanoudou D. Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle. Mol Cell Biol. 2009 Nov;29(22):6046-58. doi: 10.1128/MCB.00654-09.

Arvanitis DA, Sanoudou D, Kolokathis F, Vafiadaki E, Papalouka V, Kontrogianni-Konstantopoulos A, Theodorakis GN, Paraskevaidis IA, Adamopoulos S, Dorn GW 2nd, Kremastinos DT, Kranias EG. The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy. Eur Heart J. 2008 Oct;29(20):2514-25. doi: 10.1093/eurheartj/ehn328.

Sanoudou D, Haslett JN, Kho AT, Guo S, Gazda HT, Greenberg SA, Lidov HG, Kohane IS, Kunkel LM, Beggs AH. Expression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4666-71.

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