Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Spiros Spiros Georgopoulos, PhD
Researcher B'

Telephone : +30 210 6597 187
Fax : +30 210 6597 545
e-mail :

Center :

Basic Research

Lab Site :

Georgopoulos Lab

Brief Bio

Spiros Georgopoulos is a biologist, Researcher-Associate Professor at the Biomedical Research Foundation of the Academy of Athens, where he is in charge of the Cellular Neurobiology Laboratory and the Transgenic Core facility. He is a graduate of Biology in Athens University where he also obtained his Ph.D. degree for his thesis on TNF-a and rheumatoid arthritis at the Hellenic Pasteur Institute in Dr. George Kollias laboratory. He continued his post doctoral studies in Boston at Boston University (Boston University Medical Center) and Harvard University (Center for Neurodegenerative Diseases, Brigham and Women’s Hospital). In 2002 he was elected Assistant Professor at the University of Thessaly from where he resigned to accept the position of Researcher in the Academy of Athens.

Spiros Georgopoulos has mastered genetic approaches using genetically modified mice to understand the pathogenic mechanisms of Alzheimer’s disease. His scientific work is widely renowned for the identification of the role of cholesterol related genes in Alzheimer’s disease pathogenesis. His laboratory is supported by competitive grants from national sources and the European Commission, as well as by the pharmaceutical industry.

Spiros Georgopoulos has been appointed as a national member in the Joint Programme in Neurodegenerative Diseases and has also participated in the organization of different actions in neurodegenerative diseases in Europe. He is a reviewer in International scientific journals and National, European and International Funding Organizations. He teaches in post-graduate courses in Athens University and graduate students that have received training in his lab continue successfully their research activities in Greece and abroada

Selected Publications

Evi Paouri and Spiros Georgopoulos. Systemic inflammation and AD: implications of a bidirectional communication pathway between the periphery and the brain. Current Alzheimer’s Research. 2019 Mar 21. doi: 10.2174/1567205016666190321154618. [Epub ahead of print]

Evi Paouri, Rania Tzara, Sophia Zenelak and Spiros Georgopoulos. Genetic Deletion of Tumor Necrosis Factor-α Attenuates Amyloid-β Production and Decreases Amyloid Plaque Formation and Glial Response in the 5XFAD Model of Alzheimer's Disease. Journal of Alzheimer’s Disease. 2017;60(1):165-181. doi: 10.3233/JAD-170065.

Evi Paouri, Sophia Zenelak, Ourania Tzara, Georgia-Ioanna Kartalou and Spiros Georgopoulos. Peripheral Tumor Necrosis Factor-Alpha (TNF-α) Modulates Amyloid Pathology by Regulating Blood-Derived Immune Cells and Glial Response in the Brain of AD/TNF Transgenic Mice. The Journal of Neuroscience. 2017 May 17;37(20):5155-5171. doi: 10.1523/JNEUROSCI.2484-16.2017.

Antigoni Diokmetzidou, Elisavet Soumaka, Ismini Kloukina, Mary Tsikitis, Manousos Makridakis, Aimilia Varela, Constantinos H Davos, Spiros Georgopoulos, Vasiliki Anesti, Antonia Vlachou, and Yassemi Capetanaki. Desmin and & [alpha] B-Crystallin Interplay in Maintenance of Mitochondrial Homeostasis and Cardiomyocyte Survival. Journal of Cell Science.  2016 Aug 26. pii: jcs.192203.

Isabel Varela Nieto, Dora Brites, Niki Karagianni, Saida Ortolano, Spiros Georgopoulos, Ana Luisa Cardoso, Susana Novella, Guenter Lepperdinger, Angelika Meyer, Ulrike Trendelenburg, Thomas von Zglinicki, Ronald van Os. Frailty in mouse aging: a conceptual approach. Mechanisms of Aging and Disease. 2016 Jul 18. pii: S0047-6374(16)30109-9. doi: 10.1016/j.mad.2016.07.004.

Ioanna Tiniakou, Zoi Kanaki, Spiros Georgopoulos, Angeliki Chroni, Miranda Van Eck, Panagiotis Fotakis, Vassilis I. Zannis, Dimitris Kardassis. Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice. Atherosclerosis. 2015 Aug 24;243(1):77-85. doi: 10.1016/j.atherosclerosis.2015.08.028.

Katia Sesele, Kalliopi Thanopoulou, Evi Paouri, Eliona Tsefou, Apostolos Klinakis, and Spiros Georgopoulos. Conditional inactivation of nicastrin inhibits fibrillary amyloid plaque formation in an Alzheimer’s disease mouse model. Aging Cell. 2013 Jul 4. doi: 10.1111/acel.12131.

Helga E de Vries, Gijs Kooij, Danny Frenkel, Spiros Georgopoulos, Alon Monsonego and Damir Janigro. Inflammatory events at blood-brain barrier in neuro-inflammatory and neurodegenerative disorders: implications for clinical disease. Epilepsia. 2012 Nov;53 Sup 6:45-52. doi: 10.1111/j.1528-1167.2012.03702 .x. 

Fragkouli A, Papatheodoropoulos C, Georgopoulos S, Stamatakis A, Stylianopoulou F, Tsilibary EC, Tzinia AK. Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9. J Neurochem. 2011 Dec 22. doi: 10.1111/j.1471-4159.2011.07637.x.

Katsouri L and Georgopoulos S. Lack of LDL Receptor Enhances Amyloid Deposition and decreases Glial Response in an Alzheimer's Disease Mouse Model. PLoS One. 2011;6 (7):e21880. Epub 2011 Jul 6.

Karuna R, Holleboom AG, Motazacker MM, Kuivenhoven JA, Frikke-Schmidt R, Tybjaerg-Hansen A, Georgopoulos S, van Eck M, van Berkel TJ, von Eckardstein A, Rentsch KM. Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. Atherosclerosis. 2011 Feb;214(2):448-55.

Thanopoulou K, Fragkouli A, Stylianopoulou F and Georgopoulos S. Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model. PNAS. 2010 Nov 30;107(48):20816-21.


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