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The major research interests of the Georgopoulos’ laboratory focus on the elucidation of the pathogenic mechanisms of Alzheimer’s disease, related to cholesterol metabolism and inflammation. A genetic approach with genetically modified mice is employed to explore the molecular and cellular mechanisms involved.

We have identified, with the generation and use of various mouse models a number of cholesterol and inflammation related genes involved in Alzheimer’s disease pathogenesis. Our results have revealed a novel association between cholesterol transport and inflammation in the pathogenesis of Alzheimer’s disease.