BRFAA - Biomedical Research Foundation Academy Of Athens
Biomedical Research Foundation Academy Of AthensAcademy Of Athens


The major research interests of the Georgopoulos’ laboratory focus on the elucidation of the pathogenic mechanisms of Alzheimer’s disease, related to cholesterol metabolism and inflammation. A genetic approach with genetically modified mice is employed to explore the molecular and cellular mechanisms involved.

We have identified, with the generation and use of various mouse models a number of cholesterol and inflammation related genes involved in Alzheimer’s disease pathogenesis. Our results have revealed a novel association between cholesterol transport and inflammation in the pathogenesis of Alzheimer’s disease.