BRFAA - Biomedical Research Foundation Academy Of Athens
Biomedical Research Foundation Academy Of AthensAcademy Of Athens


Inflammation, the activation of the immune system, is the major mechanism of the body to fight disease. Inflammation can also happen in the brain, called neuroinflammation. Clinical and experimental evidence have pointed neuroinflammation as a key element in Alzheimer’s disease pathogenesis and moreover have suggested a possible connection between peripheral inflammation and the brain. The role of this interaction in the pathogenesis of neurodegenerative diseases as Alzheimer’s Disease (AD) is still unknown and the molecular and cellular mechanisms connecting the peripheral immune system and the nervous system are not well understood. The Georgopoulos’ lab focuses on these questions conducting studies of neuro-immune interactions in preclinical AD mouse models to elucidate the role of peripheral immunity and neuroinflammation in AD.