Publications

Nikoleta Kalovyrna, Olympia Apokotou, Sotiria Boulekou, Evi Paouri, Athena Boutou and Spiros Georgopoulos. A 3′UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice. Scientific Reports 2020 May 26;10(1):8670. doi:10.1038/s41598-020-65378-2. IF:4,525

Evi Paouri and Spiros Georgopoulos. Systemic and CNS Inflammation Crosstalk: Implications for Alzheimer’s Disease. Current Alzheimer’s Research. 2019;16(6):559-574. doi: 10.2174/1567205016666190321154618. IF:3,309

Evi Paouri, Rania Tzara, Sophia Zenelak and Spiros Georgopoulos. Genetic Deletion of Tumor Necrosis Factor-α Attenuates Amyloid-β Production and Decreases Amyloid Plaque Formation and Glial Response in the 5XFAD Model of Alzheimer’s Disease. Journal of Alzheimer’s Disease. 2017 Aug 17. doi: 10.3233/JAD-170065. IF:3,517

Evi Paouri, Sophia Zenelak, Ourania Tzara, Georgia-Ioanna Kartalou and Spiros Georgopoulos. Peripheral Tumor Necrosis Factor-Alpha (TNF-α) Modulates Amyloid Pathology by Regulating Blood-Derived Immune Cells and Glial Response in the Brain of AD/TNF Transgenic Mice. The Journal of Neuroscience. 2017 May 17;37(20):5155-5171. doi: 10.1523/JNEUROSCI.2484-16.2017. IF:6,074

Lamprokostopoulou Agaristi, … Georgopoulos Spiros, Charmandari Evangelia. Impaired Cardiac Function in a mouse Model of Generalized Glucocorticoid Resistance. Hormone Research in Pediatrics. 2016 Volume 86, Page 69-70 IF: 2,324

Antigoni Diokmetzidou, …, Spiros Georgopoulos, Vasiliki Anesti, Antonia Vlachou, and Yassemi Capetanaki. Desmin and & [alpha] B-Crystallin Interplay in Maintenance of Mitochondrial Homeostasis and Cardiomyocyte Survival. Journal of Cell Science.  2016 Aug 26. pii: jcs.192203.IF:4,401

Isabel Varela Nieto, Dora Brites, Niki Karagianni, Saida Ortolano, Spiros Georgopoulos, Ana Luisa Cardoso, Susana Novella, Guenter Lepperdinger, Angelika Meyer, Ulrike Trendelenburg, Thomas von Zglinicki, Ronald van Os. Frailty in mouse aging: a conceptual approach. Mechanisms of Aging and Disease. 2016 Jul 18. pii: S0047-6374(16)30109-9. doi: 10.1016/j.mad.2016.07.004.IF:3,739

Ioanna Tiniakou, Zoi Kanaki, Spiros Georgopoulos, Angeliki Chroni, Miranda Van Eck, Panagiotis Fotakis, Vassilis I. Zannis, Dimitris Kardassis. Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice. Atherosclerosis. 2015 Aug 24;243(1):77-85. doi: 10.1016/j.atherosclerosis.2015.08.028. IF:4,467

Katia Sesele, Kalliopi Thanopoulou, Evi Paouri, Eliona Tsefou, Apostolos Klinakis, and Spiros Georgopoulos. Conditional inactivation of nicastrin inhibits fibrillary amyloid plaque formation in an Alzheimer’s disease mouse model. Aging Cell 2013 Dec;12(6):1032-40. doi: 10.1111/acel.12131. Epub 2013 Aug 11. (http://www.ncbi.nlm.nih.gov/pubmed/23826707)

Helga E de Vries, Gijs Kooij, Danny Frenkel, Spiros Georgopoulos, Alon Monsonego and Damir Janigro. Inflammatory events at blood-brain barrier in neuro-inflammatory and neurodegenerative disorders: implications for clinical disease. Epilepsia 2012 Nov;53 Sup 6:45-52. doi: 10.1111/j.1528-1167.2012.03702 .x. (http://www.ncbi.nlm.nih.gov/pubmed/23134495)

Fragkouli A, Papatheodoropoulos C, Georgopoulos S, Stamatakis A, Stylianopoulou F, Tsilibary EC, Tzinia AK. Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9. J Neurochem. 2011 Dec 22. doi: 10.1111/j.1471-4159.2011.07637.x. (http://www.ncbi.nlm.nih.gov/pubmed/22192143)

Katsouri L and Georgopoulos S. Lack of LDL Receptor Enhances Amyloid Deposition and decreases Glial Response in an Alzheimer's Disease Mouse Model. PLoS One. 2011;6 (7):e21880. Epub 2011 Jul 6. (http://www.ncbi.nlm.nih.gov/pubmed/21755005)

Thanopoulou K, Fragkouli A, Stylianopoulou F and Georgopoulos S. Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model. Proc Natl Acad Sci. 2010 Nov 30;107(48):20816-21. Epub 2010 Nov 12. (http://www.ncbi.nlm.nih.gov/pubmed/21076037)

Karuna R, Holleboom AG, Motazacker MM, Kuivenhoven JA, Frikke-Schmidt R, Tybjaerg-Hansen A, Georgopoulos S, van Eck M, van Berkel TJ, von Eckardstein A, Rentsch KM. Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. Atherosclerosis. 2011 Feb; 214(2): 448-55. (http://www.ncbi.nlm.nih.gov/pubmed/21130455)

Rütti S, Ehses JA, Sibler RA, Prazak R, Rohrer L, Georgopoulos S, Meier DT, Niclauss N, Berney T, Donath MY, von Eckardstein A. Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells. Endocrinology. 2009 Oct;150(10):4521-30. Epub 2009 Jul 23. (http://www.ncbi.nlm.nih.gov/pubmed/21130455)

Horn-Yuan Kan, Spiros Georgopoulos, Markella Zanni, Adelina Shkodrani, Alexandros Tzatsos, Hou Xiang Xie and Vassillis I. Zannis. Contribution  of the hormone response element of the Proximal ApoA-I promoter and the ApoCIII  and the C/EBP binding site of the proximal apoA-I promoter to the hepatic and intestinal expression of the ApoA-I ApoCIII genes in transgenic mice. Biochemistry 2004 May 4;43(17):5084-93

Spiros Georgopoulos, Ann McKee, Horn-Yuan Kan and Vassillis I. Zannis. “Generation and characterization of two transgenic mouse lines expressing the Human apoE2: Neuronal and glial expression of apoE2 gene in the brain affects synaptophysin levels” Biochemistry 2002 Jul 30;41(30):9293-301

Spiros Georgopoulos, Horn-Yuan Kan, Vassilis I. Zannis. “The SP1 sites of the ApoCIII enhancer are essential for the expression of the ApoCIII gene and contribute to the hepatic and intestinal expression of the apoA-I gene in transgenic mice”. Nucleic Acids Res. 2000 Dec 15;28(24):4919-29

Horn-Yuan Kan, Spiros Georgopoulos, Vassillis I. Zannis. “The hormone response element of the human ApoCIII promoter/enhancer are essential for the expression of the human ApoCIII gene and they control the hepatic expression of the ApoA-I gene in transgenic mice”. J Biol Chem. 2000 Sep 29;275(39):30423-31

Kan HY, Georgopoulos S, Zanni E, Zannis V. “Probing the in vivo regulation and tissue specific expression of the APOA-I and APOCIII gene cluster in transgenic mice”. Atherosclerosis 144: 164-164, Suppl. 1 May 1999

Kan HY, Georgopoulos S, Ladd DJ, Zannis IV. “The hormone response element (HRE) of the human ApoCIII enhancer is essential for the intestinal expression of the human ApoA-I gene in transgenic mice”. Circulation 98: (17) 379-379 Suppl. Oct 27 1998

Douni E, Akassoglou K, Alexopoulou L, Georgopoulos S, Haralambous S, Hill S, Kassiotis G, Kontoyiannis D, Pasparakis M, Plows D, Probert L, Kollias G. Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. J Inflammation 1996;47(1-2):27-38

Georgopoulos, S., Plows, D. and Kollias, G. Transmembrane TNF is sufficient to induce localised tissue toxicity and chronic inflammatory arthritis in transgenic mice. J Inflammation, 1996 46:86-97.

Grell, M., Douni, E., Wajant, H., Lohden, M., Maxeiner, B., Georgopoulos, S., Lesslauer, W., Kollias, G., Pfizenmaier, K. and Scheurich P. A new role for the TNF receptor type II:hyperactivation by the transmembrane form of the ligand. Cell, (1995) Vol. 83, pp.793-802.

G. Kollias, E. Douni, S. Georgopoulos, M. Pasparakis and L. Probert. Analysis of tumour necrosis factor biology in transgenic mice. Journal of Cellular Biochemistry: 92-92 Suppl. 17B Jan. 26 1993.

Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, Kollias G, Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 1991 Dec;10(13):4025-4031