Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Andreas Andreas Papapetropoulos, PhD, FAHA, FBPharmacolS
University Faculty, Affiliated Investigator

Telephone : +30 210 6597 465
Fax : +30 210 6597 545
e-mail :

Center :

Clinical, Experimental Surgery & Translational Research

Brief Bio

Andreas Papapetropoulos received his bachelor’s degree in Pharmacy from the University of Patras (Greece) and earned his PhD in Pharmacology with distinction at the Medical College of Georgia (Augusta, GA). After completing his graduate training he moved to the Boyer Center for Molecular Medicine at Yale University as a postdoctoral fellow. In 1999, he returned to Greece, joining the Faculty of the University of Athens as Assistant Professor of Pharmacology in the School of Nursing and become group leader in the “George P. Livanos” Laboratory at the Department of Critical Care and Pulmonary Services of the Medical School. From 2003-2013 he served as Associate and later as Professor and Director of the Laboratory of Molecular Pharmacology at the Department of Pharmacy at the University of Patras. He is currently Professor of Pharmacology at the School of Pharmacy at the University of Athens. He serves on the Editorial Board of the British Journal of Pharmacology and Arteriosclerosis, Thrombosis & Vascular Biology and has refereed for over 50 international journals. He is board certified in Pharmacy and is a European Medicines Agency expert. He is also a Fellow of the American Heart Association and a Fellow of the British Pharmacological Society.

His research is funded by intramural, national, European and international agencies; he has received >2,5 million € for his research in the last 10 years. He has published more than 100 papers in peer-reviewed journals that have received >6,700 citations. He has trained 5 PhD students and 9 postdoctoral fellows.  He frequently reviews for national granting agencies from Europe and Asia.

Andreas Papapetropoulos has studied the physiological functions of the nitric oxide/cGMP pathway and its contribution to disease initiation and progression. He has explored the therapeutic potential of modulators of the NO/cGMP pathway in cardiovascular and lung disease and has studied the pharmacology of soluble guanylyl cyclase (sGC) activators and stimulators. More recently, he has shifted the focus of his research to the role of hydrogen sulfide, a new gaseous mediator, in the vasculature.

Selected Publications

Papapetropoulos, A., G. García-Cardeña, J.A. Madri and W. C. Sessa. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J. Clin. Invest. 100:3131-3139, 1997.

Fulton, D., J.P. Gratton, T.J. McCabe, J. Fontana, Y. Fujio, K.Walsh, T.F. Franke, A. Papapetropoulos and W.C. Sessa. Regulation of endothelium-derived nitric oxide production by Akt. Nature 399:597-601, 1999

A. Papapetropoulos, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, Jeschked MG, Branskid L.K., Herndon D.N., Wang R. and Szabo C. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc Natl. Acad Sci USA 106:21972-7, 2009

Sierra-Honigmann M.R., A. K. Nath, C. Murakami, G. Garcia-Cardeña, A. Papapetropoulos W. C. Sessa, L.A. Madge, J. S. Schechner, M.B. Schwabb, P.J. Polverini and J. Flores-Riveros. Biological action of leptin as an angiogenic factor. Science 281: 1683-1686, 1998.

Z. Zhou, N. Sayed, A. Pyriochou, C. Roussos, D. Fulton, A. Beuve, A Papapetropoulos. Protein Kinase G Phosphorylates Soluble Guanylyl Cyclase on Serine 64 and Inhibits Its Activity. Arterioscler Thromb Vasc Biol. 28:1803-10, 2008

Papapetropoulos, A., P. Piccardoni, G. Cirino, M. Bucci, R. Sorrentino, C. Cicala, K. Johnson, V. Zachariou, W. C. Sessa and D.C. Altieri. Hypotension and inflammatory gene expression triggered by factor Xa-nitric oxide signalling. Proc. Natl. Acad. Sci USA  95:4738-4742, 1998

García-Cardeña, G., R. Fan, V. Shah, R. Sorrentino, G. Cirino, A. Papapetropoulos and W. C. Sessa. Dynamic activation of nitric oxide synthase by Hsp90. Nature  392:821- 824, 1998

C. Coletta, A. Papapetropoulos, K. Erdelyi, G. Olah, K. Modis, P. Panopoulos, D. Gero, C. Szabo. Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of vascular function. Proc Natl Acad Sci USA 109:9161-6, 2012

Z. Zhou, S. Gross, C. Roussos, S Meurer, W. Müller-Esterl and A. Papapetropoulos. Structural and functional characterization of the dimerization region of soluble guanylyl cyclase. J. Biol. Chem. 279:24935-24943, 2004

A Pyriochou, D. Beis, V. Koika, C. Potytarchou, E. Papadimitriou, Z. Zhou, A. Papapetropoulos. Soluble guanylyl cyclase activation promotes angiogenesis. J. Pharmacol. Exp. Ther 319:663-71, 2006

D.C. Simoes, T. Vassilakopoulos, D. Toumpanakis, K. Petrochilou, C. Roussos, A. Papapetropoulos. Angiopoietin-1 Protects Against Airway Inflammation and Hyperreactivity in Asthma. Am J Respir Crit Care Med. 177:1314-21, 2008 

A. Marazioti, M. Bucci M, C. Coletta, V. Vellecco, P. Baskaran, C. Szabo, G. Cirino, A.R.Marques,  B. Guerreiro, A.M. Gonçalves, J.D. Seixas, A. Beuve, C.C. Romão, A. Papapetropoulos. Inhibition of nitric oxide-stimulated vasorelaxation by carbon monoxide-releasing molecules. Arterioscler Thromb Vasc Biol. 31:2570-2576, 2011


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