Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Dimitra Dimitra Mangoura, MD, PhD
Investigator - Professor Level

Telephone : +30 210 6597 087, 081
Fax : +30 210 6597 545
e-mail : mangoura@bioacademy.gr


Center :

Basic Research

Lab Site :

Mangoura Lab


Brief Bio

Dr. Dimitra Mangoura received her MD from the University of Athens in 1985 and her Ph.D. in Neurobiology from the University of Colorado, Denver, Colorado, USA, and then the University of Athens in 1988.  Under the auspices of an National Institute of Health (NIH) fellowship and then a National Individual Research Award also from NIH, she completed her postdoctoral studies at The University of Chicago, Chicago, USA, on phosphorylation-dependent signaling mechanisms in neural progenitor cell development and the effects of opiates.  In 1994, she joined the Faculty of  Pediatrics at The University of Chicago, and in 1997 the Faculty in the Committees of Neurobiology and of Cell Physiology.  In 2002 she joined the Faculty of the Center of Preventive Medicine, Neurosciences & Social Psychiatry and acted as its director until 2013.  Dr. Mangoura has led an internationally recognized program on mechanism of differentiation in developing neurons and astrocytes, funded by NIH and other USA foundations, including Louis Block and the Brain Research Foundations, and more recently by European Union (EU) and Greek national agencies.   Her academic work includes teaching in Medical Schools, graduate and undergraduate programs in USA and graduate programs in Greek Universities.   Dr. Mangoura has served as a reviewer in NIH Study Sections and continues to be a member of  evaluation rosters for the European Union and other countries and to serve in editiorial boards.  She is an elected Council Member of the International Society for Neurochemistry for which she chairs the Schools Initiative Committee.

Selected Publications

Constantinos Fedonidis, C., Alexakis, N., Koliou, X., Asimaki, O., Tsirimonaki, E., Mangoura, D. Long-term changes in the ghrelin-CB1R axis associated with the maintenance of lower body weight after Sleeve Gastrectomy, Nutrition & Diabetes, in press, 2014

Tsirimonaki, E., Fedonidis, C., Pneumaticos, S. G., Tragas, A. A., Michalopoulos, I., Mangoura D. PKCε Signalling Activates ERK1/2, and Regulates Aggrecan, ADAMTS5, and miR377 Gene Expression in Human Nucleus Pulposus Cells. PLoS One. 2013 Nov 28;8(11):e82045. PubMed PMID: 24312401.

Zisopoulou, S., Asimaki, O., Leondaritis, G,, Vasilaki, A., Sakellaridis, N., Pitsikas, N., Mangoura, D. PKC-epsilon activation is required for recognition memory in the rat. Behav Brain Res. 2013 Sep 15;253:280-9. Epub 2013 Jul 30. PubMed PMID: 23911427.

Asimaki, O., Leondaritis, G., Lois, G., Sakellaridis, N. and Mangoura, D. Cannabinoid 1 receptor-dependent transactivation of fibroblast growth factor receptor 1 emanates from lipid rafts and amplifies extracellular signal-regulated kinase 1/2 activation in embryonic cortical neurons. J Neurochem. 2011 Mar;116(5):866-73.

Asimaki, O. and Mangoura, D.  Cannabinoid receptor 1 induces a biphasic ERK activation via multiprotein signaling complex formation of proximal kinases PKCε, Src, and Fyn in primary neurons. Neurochem Int. 58(2):135-44, 2011.

Leondaritis G., Koliou X., Johnson S., Li C., Florakis A., Dimas K., Sakellaridis N., Mangoura D. Interplay between protein kinase C isoforms alpha and epsilon, neurofibromin, and the Ras/MAPK pathway in neuroblastoma differentiation. Neuroblastoma, Intech. 2011; ISBN:978-953-307-796-3.

Theofilopoulos, S., Lykidis A, Leondaritis G, Mangoura D. Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways. Biochim Biophys Acta. 2008; 1781(11-12):731-42.

Mangoura, D.,  Sun, Y., Li, C., Singh, D., Gutmann, D., Flores, A., Ahmed, M., and Vallianatos, G.  Phosphorylation of neurofibromin by PKC: a molecular switch in EGF receptor signaling in differentiating neural cells, Oncogene, 2006; 25(5):735-45.

McLoughlin,  D., Tsirimonaki, E., Vallianatos, G., Tsezou, A., Sakellaridis, N.,  Mangoura, D. Stable expression of a neuronal progenitor dopaminergic phenotype in cell lines derived from human amniotic fluid cells.  J. Neurosci. Res. 2006 ; 83(7) :1190-200.

Mangoura, D., Theofilopoulos,  S., Karouzaki, S., and Tsirimonaki, E. 12-O-tetradecanoyl-phorbol-13-acetate-dependent up-regulation of dopaminergic gene expression requires Ras and neurofibromin in human IMR-32 neuroblastoma. J Neurochem. 2005 [Epub], J. Neurochem. 2006;1:97-103.

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