Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Ioannis Ioannis Michalopoulos, PhD
Staff Research Scientist B'

Telephone : +30 210 6597 127
Fax : +30 210 6597 545
e-mail :

Center :

Systems Biology

Lab Site :

Michalopoulos Lab

Brief Bio

Ioannis Michalopoulos received his BSc in Biology from the University of Athens and his PhD in Molecular Biology from the University of St Andrews. Soon after the publication of the first draft of the human genome, he moved to Bioinformatics, doing post-doctoral research in the University of Leeds (2001-2005) and in the Biomedical Research Foundation, Academy of Athens (2006-2008). Since 2008, he has been working as a Staff Research Scientist – Associate Professor Level in the Centre of Systems Biology of the Biomedical Research Foundation. He is in charge of the design and maintenance of various biobank web sites (Hellenic Cord Blood Bank, Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-GR), Hellenic Biobank for Parkinson Disease, etc). His research activities include many collaboration projects with experimental researchers and computer scientists in the field of Genomics, Transcriptomics, Epigenomics, Proteomics, etc. His interests include de novo genome assembly, gene discovery and genome annotation, differential gene expression and coexpression, construction of gene networks, differential DNA methylation, transcription factor binding site prediction, miRNA target discovery, structural bioinformatics, phylogenomics, radiogenomics, cytogenetics and pharmacogenomics. He is an expert on Linux operating system administration, Apache2 web server configuration, MySQL database management and PHP and C programming. As a web developer, he has developed many interactive bioinformatics tools. He teaches Bioinformatics, Microarray Data Analysis and Research Methodology in MSc courses such as Bioinformatics, System Biology, Molecular Medicine, Dietetics and Nutrition, etc. Ioannis Michalopoulos is a founding member of the Hellenic Society of Computation Biology and Bioinformatics (HSCBB) of which he was a Treasurer (2013-17) and an Associate Member of the World Academy of Sciences. He has co-organised many national and international conferences. He is a reviewer of Nucleic Acids Research, Bioinformatics, Database, Journal of Oral Pathology and Medicine, Breast Cancer Research, PLoS One, BMC Bioinformatics, etc.

Selected Publications

Zogopoulos, V.L., Malatras, A., Kyriakidis, K., Charalampous, C., Makrygianni, E.A., Duguez, S., Koutsi, M.A., Pouliou, M., Vasileiou, C., Duddy, W.J., Agelopoulos, M., Chrousos, G.P., Iconomidou, V.A., and Michalopoulos, I. (2023). HGCA2.0: An RNA-Seq Based Webtool for Gene Coexpression Analysis in Homo sapiens. Cells 12, 388.

Borbolis, F., Ranti, D., Papadopoulou, M.D., Dimopoulou, S., Malatras, A., Michalopoulos, I., and Syntichaki, P. (2023). Selective Destabilization of Transcripts by mRNA Decapping Regulates Oocyte Maturation and Innate Immunity Gene Expression during Ageing in C. elegans. Biology 12, 171.

Angelopoulou, E., Bozi, M., Simitsi, A.M., Koros, C., Antonelou, R., Papagiannakis, N., Maniati, M., Poula, D., Stamelou, M., Vassilatis, D.K., Michalopoulos, I., Geronikolou, S., Scarmeas, N., and Stefanis, L. (2022). Clinical differences between early-onset and mid-and-late-onset Parkinson’s disease: Data analysis of the Hellenic Biobank of Parkinson’s disease. J Neurol Sci 442, 120405.

Zogopoulos, V.L., Saxami, G., Malatras, A., Papadopoulos, K., Tsotra, I., Iconomidou, V.A., and Michalopoulos, I. (2022). Approaches in Gene Coexpression Analysis in Eukaryotes. Biology 11, 1019.

Zogopoulos, V.L., Malatras, A., and Michalopoulos, I. (2022). Gene coexpression analysis in Arabidopsis thaliana based on public microarray data. STAR Protoc 3, 101208.

Barba, E., Kontou, P. I., Michalopoulos, I., Bagos, P. G., and Braliou, G. G. (2022). Association of ITPA gene polymorphisms with adverse effects of AZA/6-MP administration: a systematic review and meta-analysis. Pharmacogenomics J, 22, 39–54.

Zogopoulos, V. L., Spaho, K., Ntouka, C., Lappas, G. A., Kyranis, I., Bagos, P., Spandidos D. A., and Michalopoulos, I. (2021). TFBSPred: A functional transcription factor binding site prediction webtool for humans and mice. Int J Epigenetics 1, 9.

Zogopoulos, V.L., Saxami, G., Malatras, A., Angelopoulou, A., Jen, C.H., Duddy, W.J., Daras, G., Hatzopoulos, P., Westhead, D.R., and Michalopoulos, I. (2021). Arabidopsis Coexpression Tool: a tool for gene coexpression analysis in Arabidopsis thaliana. iScience 24, 102848.

Kalogirou, E.M., Thermos, G., Zogopoulos, V., Foutadakis, S., Michalopoulos, I., Agelopoulos, Μ. and Tosios, Κ.Ι. (2021). The immunohistochemical profile of basal cell nevus syndrome–associated and sporadic odontogenic keratocysts: a systematic review and meta-analysis. Clin Oral Invest 25, 3351–3367

Gavrielatos, M., Kyriakidis, K., Spandidos, D.A., and Michalopoulos, I. (2021). Benchmarking of next and third generation sequencing technologies and their associated algorithms for de novo genome assembly. Mol Med Rep 23, 251.


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