Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Constantinos Constantinos Anagnostopoulos, MD, PhD, FRCP, FRCR, FESC
Investigator - Professor Level

Telephone : +30 210 6597 126, 067
Fax : +30 210 6597 502
e-mail :

Center :

Clinical, Experimental Surgery & Translational Research

Lab Site :

Anagnostopoulos Lab

Core Facility Site :

micro PET/CT

Brief Bio

Constantinos Anagnostopoulos M.D, Ph.D, FRCP, FRCR, FESC is a Nuclear Medicine Physician, Faculty member of BRFAA and Research Director at the Center for Clinical Research, Experimental Surgery, and Translational Research.  Dr Anagnostopoulos received his Medical Degree (M.D) from the University of Thessaloniki in 1985.  He trained in Nuclear Medicine at the Theagenio Hospital of Thessaloniki and completed his post-graduate training at the Royal Marsden and Royal Brompton Hospitals in England and the Brigham and Women’s Hospital, Boston, US. During his post-graduate training he acquired expertise in Nuclear Cardiology and hybrid imaging (PET/CT and SPECT/CT).

He received his Certificate for Completion of Specialist Training (CCST), London UK, in 1996 and his Ph.D from the University of Athens in the same year after completing a joint research program between the latter and the National Heart and Lung Institute, Imperial College, London UK.  He has been awarded the Fellowship of the European Society of Cardiology (FESC) in 2000, and also the Fellowships of the Royal College of Radiologists (FRCR) and the Royal College of Physicians (FRCP) in 2003 and 2006 respectively.

He was Senior Lecturer in Nuclear Medicine at the Institute of Cancer and the William Harvey Research Institute of Barts and The London School of Medicine, where he was also Head of the Nuclear Medicine-PET/CT Department (2008-2010).  Before this post, he had a joint appointment at the Royal Brompton and the Chelsea and Westminster Hospital as Consultant in Nuclear Medicine and Hon. Senior Lecturer at the Imperial College (from 1998 to 2008).  He was also Hon. Senior Lecturer at the University College London, UK from 2006 to 2011.

Dr Anagnostopoulos has served as President of the British Nuclear Cardiology Society of  and Council member both of the British Cardiovascular Society and the British Nuclear Medicine Society (2002 and 2003) and also of the European Society of Cardiology working group in Nuclear Cardiology and Cardiac CT (2002-2010). He has been advisor to the Department of Health, UK, through the National Institute for Clinical Excellence (NICE) on scoping the document; “Appraisal of Myocardial Perfusion Imaging” and external expert of the appraisal committee.  He is member of the editorial board of leading specialty journals and he has also served as Guest Editor of HEART. He is chair and member of UK and European Guidelines Committees respectively and also book editor (Non Invasive Imaging of Myocardial Ischemia, Springer) and leading author or co-author of numerous book chapters and papers.

Dr Anagnostopoulos has an extensive range of national and international teaching activities. His research interests focus mainly on the field of cardiovascular imaging and pursues these, through collaboration with a number of National and European centres.  He is principle investigator or co-investigator in a number of studies as well as co-applicant in the FP-7 funded EVINCI (Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease-the EVINCI) project and partner representing BRFAA both in the PmedGR and the Infrafrontier-GR programs.  His pioneering work on comparative assessment of left ventricular function by novel radionuclide techniques and Cardiac Magnetic Resonance (CMR), heart failure imaging, and absolute perfusion quantification using PET has been cited extensively in the literature.

Selected Publications

Brili S, Oikonomou E, Antonopoulos AS, Pianou N, Georgakopoulos A, Koutagiar I, Kafouris P, Stroumpouli E, Dounis C, Metaxas M, Spyrou G, Anagnostopoulos CD*, Tousoulis D. 18F-FDG PET/CT imaging detects aortic wall inflammation in patients with repaired coarctation of aorta. Circ Cardiovasc Imaging. 2018 Jan;11(1):e007002. doi: 10.1161/CIRCIMAGING.117.007002.

Toutouzas K, Skoumas J, Koutagiar I, Benetos G, Pianou N, Georgakopoulos A, Galanakos S, Antonopoulos A, Drakopoulou M, Oikonomou EK, Kafouris P, Athanasiadis E, Metaxas M, Spyrou G, Pallantza Z, Galiatsatos N, Aggeli C, Antoniades C, Keramida G, Peters AM, Anagnostopoulos CD*, Tousoulis D*. Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia. J Clin Lipidol. 2017 pii: S1933-2874(17)30487-7. doi: 10.1016/j.jacl.2017.10.019.
* joint senior authors.

Konstantinos Toutouzas, Iosif Koutagiar, Georgios Benetos, Constantina Aggeli, Alexandros Georgakopoulos, Emmanouil Athanasiadis, Nikoletta Pianou, Sofoklis Trachanellis, Nikolaos Patelis, George Agrogiannis, Pavlos Kafouris, Konstantinos Filis, MD, Nikolaos Bessias, Christos Klonaris, George Spyrou, Eleftherios Tsiamis, Elias Siores, Efstratios Patsouris, Dennis Cokkinos, Dimitris Tousoulis and Constantinos D. Anagnostopoulos. Local inflammation of carotid atherosclerotic plaques evaluated by 18F-positron emission tomography is associated with increased temperature: validation with histopathological and immunohistochemistry. Eur Heart J- Cardiovascular Imaging 2017; 18(11): 1236-1244.

Neglia D, Rovai D, Caselli C et al. Detection of significant coronary artery disease by noninvasive anatomical and functional imaging. Circ Cardiovasc Imaging. 2015;8:e002179. DOI: 10.1161/CIRCIMAGING.114.002179 - EVINCI Trial

Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P, Buechel RR, Cuocolo A, van Eck-Smit BL, Flotats A, Hacker M, Hindorf C, Kaufmann PA, Lindner O, Ljungberg M, Lonsdale M, Manrique A, Minarik D, Scholte AJ, Slart RH, Trägårdh E, de Wit TC, Hesse B. European Association of Nuclear Medicine (EANM). EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision. Eur J Nucl Med Mol Imaging. 2015 Nov;42(12):1929-40. doi: 10.1007/s00259-015-3139-x. Epub 2015 Aug 21.

Anagnostopoulos C, Georgakopoulos A, Pianou N and Nekolla SG. Assessment of Myocardial Perfusion and Viability by Positron Emission Tomography. Int J Cardiol 2013; 167(5):1737-49.

E Reyes, J Stirrup, M Roughton; S D'Souza, S Richard Underwood and C Anagnostopoulos. Attenuation of adenosine-induced myocardial perfusion heterogeneity by atenolol and other cardioselective & beta-adrenoceptor blockers: A crossover myocardial perfusion imaging study. J Nucl Med 2010 ;51(7):1036-43.

C Anagnostopoulos, A Almonacid, Georges El Fakhri et al. Quantitative Relationship Between Coronary Vasodilator Reserve Assessed by Rubidium-82 PET Imaging and Coronary Artery Stenosis Severity. Eur J Nucl Med Mol Imaging 2008;35(9):1593-601.

E Moralidis, T Spyridonidis, G Arsos and C Anagnostopoulos. Identification of advanced coronary artery disease with exercise myocardial perfusion imaging: the clinical value of a novel approach for assessing lung thallium-201 uptake. Eur J Nucl Med Mol Imaging 2007;34(4):573-83.

Y Loong and C. Anagnostopoulos. The Diagnosis of Coronary Artery Disease By Radionuclide Myocardial Perfusion Imaging. A meta-analysis. HEART Suppl V. 90, (2004), V2-9.

Gunning MG, Anagnostopoulos C, Knight CJ et al. Identification of hibernating myocardium: A comparison of Tl-201, Tc-99m-Tetrofosmin and dobutamine cine magnetic resonance imaging. Circulation. 98, (1998), 1869-1874.

Anagnostopoulos C, Gunning MG, Pennell DJ, Laney R, Underwood SR. Regional Myocardial Motion and Thickening Assessed by ECG-Gated 99mTc-MIBI Emission Tomography and by Magnetic Resonance Imaging. Eur J Nucl Med. 23, (1996), 909-916


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