Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Constantinos Constantinos Anagnostopoulos, MD, PhD, FRCP, FRCR, FESC
Researcher A'

Telephone : +30 210 6597 126, 067
Fax : +30 210 6597 502
e-mail :

Center :

Clinical, Experimental Surgery & Translational Research

Lab Site :

Anagnostopoulos Lab

Core Facility Site :

micro PET/CT

Brief Bio

Constantinos Anagnostopoulos M.D, Ph.D, FRCP, FRCR, FESC is a Nuclear Medicine Physician, Faculty member of BRFAA and Research Director at the Center for Clinical Research, Experimental Surgery, and Translational Research.  Dr Anagnostopoulos received his Medical Degree (M.D) from the University of Thessaloniki in 1985.  He trained in Nuclear Medicine at the Theagenio Hospital of Thessaloniki and completed his post-graduate training at the Royal Marsden and Royal Brompton Hospitals in England and the Brigham and Women’s Hospital, Boston, US. During his post-graduate training he acquired expertise in Nuclear Cardiology and hybrid imaging.

He received his Certificate for Completion of Specialist Training (CCST), London UK, in 1996 and his Ph.D from the University of Athens in the same year after completing a joint research program between the latter and the National Heart and Lung Institute, Imperial College, London UK.  He has been awarded the Fellowship of the European Society of Cardiology (FESC) in 2000, and also the Fellowships of the Royal College of Radiologists (FRCR) and the Royal College of Physicians (FRCP) in 2003 and 2006 respectively.

Dr Anagnostopoulos is Councillor of the European Association of Cardiovascular Imaging (EACVI), European Society of Cardiology and also a member of its Research and Innovation Committee, as well as the Education Committee.  He is currently the Chairman of the working group of non invasive cardiac imaging of the Hellenic Society of Cardiology. He has served as President of the British Nuclear Cardiology Society and Council member both of the British Cardiovascular Society and the British Nuclear Medicine Society (2002 and 2003) and also of the European Society of Cardiology working group in Nuclear Cardiology and Cardiac CT (2002-2010).  He is member of the editorial board of leading specialty journals and he has also served as Guest Editor of HEART. He is chair and member of UK and European Guidelines Committees respectively and also book editor (Non Invasive Imaging of Myocardial Ischemia, Springer) and leading author or co-author of numerous book chapters and research papers.

Dr Anagnostopoulos has an extensive range of national and international teaching activities. His research interests focus on cardiovascular imaging and pursues these, through collaboration with a number of National and European centres.  He is principle investigator or co-investigator in a number of studies as well as co-applicant in the FP-7 funded EVINCI (Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease-the EVINCI) project and partner representing BRFAA both in the PmedGR and the Infrafrontier-GR programs.  His pioneering work on comparative assessment of left ventricular function by novel radionuclide techniques and Cardiac Magnetic Resonance (CMR), heart failure imaging, and absolute perfusion quantification using PET has been cited extensively in the literature.

Selected Publications

Neglia D, Liga R, Gimelli A, Podlesnikar T, Cvijić M, Pontone G, Miglioranza MH, Guaricci AI, Seitun S, Clemente A, Sumin A, Vitola J, Saraste A, Paunonen C, Sia CH, Paleev F, Sade LE, Zamorano JL, Maroz-Vadalazhskaya N, Anagnostopoulos C, Macedo F, Knuuti J, Edvardsen T, Cosyns B, Petersen SE, Magne J, Laroche C, Berlè C, Popescu BA, Delgado V; EURECA Investigators. Use of cardiac imaging in chronic coronary syndromes: the EURECA Imaging registry. Eur Heart J. 2022 Dec 1:ehac640. doi: 10.1093/eurheartj/ehac640.

Georgios-Eleftherios Kalykakis, Alexios. S Antonopoulos, Thomas Pitsargiotis, Panagiotis Siogkas, Themistoklis Exarchos, Pavlos Kafouris, Antonis Sakelarios, Riccardo Liga, Afrodity Tzifa, Andreas Giannopoulos, Arthur J.H.A. Scholte, Philipp A. Kaufmann, Oberdan Parodi, Juhani Knuuti, Dimitrios. I Fotiadis, Danilo Neglia, Constantinos. D Anagnostopoulos. Relationship of Endothelial Shear Stress with plaque features by coronary CTA and vasodilating capability by PET. Radiology 2021 (in press).

C. Vlachopoulos, I. Koutagiar, A. Georgakopoulos, A. Pouli, A. Sioni, S. Giannouli, S. Chondropoulos, I. Stergiou, E. Solomou, D. Terentes-Printzios, I. Karakitsios, P. Kafouris, A. Gaitanis, N. Pianou, A. Petrocheilou, C. Aggeli, E. Stroumpouli, T. Marinakis, M. Voulgarelis, D. Tousoulis, C. Anagnostopoulos. Lymphoma Severity and Type Are Associated With Aortic FDG Uptake by 18F-FDG PET/CT Imaging. JACC: CardioOncology, Volume 2, Issue 5, 2020, Pages 758-770, ISSN 2666-0873.

Vlachopoulos C, Koutagiar I,  Skoumas I,  Terentes-Printzios D,  Zacharis E,   Kolovou G, Stamatelopoulos K, Rallidis L, Katsiki N, Bilianou H, Liberopoulos E, Miliou A, Kafouris P, Georgakopoulos A, Gardikioti V, Tousoulis D, Anagnostopoulos C.D. Long term administration of proprotein convertase subtilisin/kexin type 9 2 inhibitors reduces arterial 18F-fluoro-2-deoxy-D-glucose (FDG) uptake. JACC Cardiovascular Imaging 2019 Dec;12(12):2573-2574. doi: 10.1016/j.jcmg.2019.09.024.

Anagnostopoulos C.D, Siogkas P, Liga R, Benetos G, Maaniitty T, Sakellarios A, Koutagiar I, Karakitsos I, Papafaklis M, Scholte A, Michalis L, Gaemperli O, Kaufmann P, Pelosi G, Parodi O, Knuuti J, Fotiadis D.I.and Neglia D. Characterization of functionally significant coronary artery disease by a novel coronary computed tomography angiography based index: a comparison with quantitative PET perfusion. European Heart Journal Cardiovascular Imaging (2019 Aug 1;20(8):897-905. doi: 10.1093/ehjci/jey199.

Kafouris P, Koutagiar I, Georgakopoulos A, Spyrou G, Visvikis D, and Anagnostopoulos C.D.; Fluorine-18 fluorodeoxyglucose positron emission tomography based textural features for prediction of event prone carotid atherosclerotic plaques. Journal of Nuclear Cardiology 2019 Nov 11. doi: 10.1007/s12350-019-01943-1.

Toutouzas K, Skoumas J, Koutagiar I, Benetos G, Pianou N, Georgakopoulos A, Galanakos S, Antonopoulos A, Drakopoulou M, Oikonomou E.K, Kafouris P, Athanasiadis E, Metaxas M, Spyrou G, Pallantza Z, Galiatsatos N, Aggeli C, Antoniades C, Keramida G, Peters A.M, Anagnostopoulos C.D. , Tousoulis D *. Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia.  Journal of Clinical Lipidology. 2018; 12(1): 33-43 doi: 10.1016/j.jacl.2017.10.019.

Brili S, Oikonomou E, Antonopoulos AS, Pianou N, Georgakopoulos A, Koutagiar I, Kafouris P, Stroumpouli E, Dounis C, Metaxas M, Spyrou G, Anagnostopoulos CD, Tousoulis D,. 18F-FDG PET/CT imaging detects aortic wall inflammation in patients with repaired coarctation of aorta. Circ Cardiovasc Imaging. 2018 Jan;11(1):e007002. doi: 10.1161/CIRCIMAGING.117.007002.

E Reyes, J Stirrup, M Roughton; S D'Souza, S Richard Underwood and C Anagnostopoulos. Attenuation of adenosine-induced myocardial perfusion heterogeneity by atenolol and other cardioselective & beta-adrenoceptor blockers: A crossover myocardial perfusion imaging study. J Nucl Med 2010 ;51(7):1036-43.

C Anagnostopoulos, A Almonacid, Georges El Fakhri et al. Quantitative Relationship Between Coronary Vasodilator Reserve Assessed by Rubidium-82 PET Imaging and Coronary Artery Stenosis Severity. Eur J Nucl Med Mol Imaging 2008;35(9):1593-601.

E Moralidis, T Spyridonidis, G Arsos and C Anagnostopoulos. Identification of advanced coronary artery disease with exercise myocardial perfusion imaging: the clinical value of a novel approach for assessing lung thallium-201 uptake. Eur J Nucl Med Mol Imaging 2007;34(4):573-83.

Anagnostopoulos C, Gunning MG, Pennell DJ, Laney R, Underwood SR. Regional Myocardial Motion and Thickening Assessed by ECG-Gated 99mTc-MIBI Emission Tomography and by Magnetic Resonance Imaging. Eur J Nucl Med. 23, (1996), 909-916


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