Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Manolis Manolis Mavroidis, PhD
Investigator - Assistant Professor Level

Telephone : +30 210 6597 057
Fax : +30 210 6597 545
e-mail : emavroeid@bioacademy.gr


Center :

Basic Research

Lab Site :

Mavroidis Lab


Brief Bio

Dr. Manolis Mavroidis studied Biology at the University of Patras, Greece, from where he graduated in 1991. He received his Ph.D. in Molecular Biology from the University of Patras, Greece in 1997. From 1992 to 1994 he worked as Research specialist at Medical School, University of Pennsylvania, USA in Dr’s J. D. Lambris laboratory, where he contacted the experimental part of his thesis, in the study of the complement system. His post-doctoral studies initially were conducted at the Division of Hematology and transfusion Medicine, Medical School, University of Patras Greece (1998) and then at the Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA (1999-2002) in Dr’s Y. Capetanaki laboratory studying the role of intermediate filament cytoskeleton in cardiomyopathy and heart failure development. He was appointed (2003) as Researcher D (Lecturer) at the Cell Biology Division in the Center for Basic Research of the Biomedical Research Foundation, Academy of Athens, Greece.

His research is focused in studying cardiomyopathy/heart failure development trying to identify targets for intervention and biomarkers of the disease. More specifically using the desmin deficient and other cytoskeleton related cardiomyopathy mice models, he tries to elucidate:
    
1) At cellular level, the role of the muscle specific intermediate filament desmin in the structure/function of cardiomyocyte structures like intercalated discs and z-discs and their role in the development of dilated cardiomyopathy.
2) At cardiac tissue level:
a)    The role of inflammatory reaction (innate immunity) in heart failure development.
b)    The role of cytoskeleton in cardiac conduction system structure and function and its role in arrhythmias and sudden cardiac death.
 

Selected Publications

Georgiadou P, Iliodromitis EK, Kolokathis F, Varounis C, Gizas V, Mavroidis M, Capetanaki Y, Boudoulas H, Kremastinos DT. Osteopontin as a novel prognostic marker in stable ischaemic heart disease: a 3-year follow-up study. Eur J Clin Invest. 2010 Feb 19

Papalouka V, Arvanitis DA, Vafiadaki E, Mavroidis M, Papadodima SA, Spiliopoulou CA, Kremastinos DT, Kranias EG, Sanoudou D. Muscle Lim Protein interacts with Cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle" Mol Cell Biol. 2009 Nov;29(22):6046-58.

Mavroidis M, Panagopoulou P, Kostavasili I, Weisleder N, Capetanaki Y. A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization. FASEB J. 2008 Sep;22(9):3318-27.

Kouloumenta A, Mavroidis M, Capetanaki Y. Proper perinuclear localization of the TRIM-like protein myospryn requires its binding partner desmin.  J Biol Chem. 2007 Nov 30;282(48):35211-21.

Yassemi Capetanaki, Robert J. Bloch, Asimina Kouloumenta, Manolis Mavroidis and Stelios Psarras. Muscle Intermediate Filaments and their Links to Membranes and Membranous Organelles. Exp Cell Res. 2007 Jun 10;313(10):2063-76.    

Fountoulakis M, Soumaka E, Rapti K, Mavroidis M, Tsangaris G, Maris A, Weisleder N, Capetanaki Y. Alterations in the heart mitochondrial proteome in a desmin null heart failure model. J Mol Cell Cardiol. 2005 Mar;38(3):461-74.

M. Mavroidis, Y. Capetanaki. Extensive induction of important mediators of fibrosis and dystrophic calcification in desmin-deficient cardiomyopathy. Am J Pathol. 2002 Mar;160(3): 943-52

D. Milner, M. Mavroidis, N. Weisleder, Y. Capetanaki. Desmin cytoskeleton linked to muscle mitochondrial distribution and respiratory function. J. Cell Biol. 2000, Sept. 150(6): 1283-1297

M. Mavroidis, O. Sunyer, J. Lambris. Isolation, primary structure and evolution of third component of chicken complement and evidence for a new member of the a2-macroglobulin family. J. Immunol. 1995,154: 2164-2174

PubMed:

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