Scientific Personnel

Brief Bio

Constantinos H. Davos graduated from Medical School, University of Patras (1989) and obtained his Doctorate Thesis 'suma cum laude' from the University of Athens (1998). He completed his training in Cardiology (1998) and was employed as Clinical Research Fellow at the Departments of Clinical Cardiology, Royal Brompton Hospital and Cardiac Medicine, National Heart and Lung Institute, London, UK from 1999 until 2001. He has experience in both basic and clinical research. His basic research expertise includes studies on myocardial hypertrophy, ischaemia and cardiomyopathies in animal models. His clinical research experience includes a broad spectrum of studies in the fields of chronic heart failure, cardiac cachexia and adult congenital heart diseases. His research interests include the study of the autonomic nervous system, the skeletal muscle contribution and the impact of exercise training in these conditions. He was responsible for the design and completion of international clinical trials, metanalyses and registries regarding chronic heart failure therapy in collaboration with the Clinical Trials and Evaluation Unit of the Royal Brompton Hospital and the Hellenic Society of Cardiology. He received the Young Cardiologists Grant from the Hellenic Society of Cardiology (2000), the Clinical Research Committee Grant from the Imperial College School of Medicine (2001), research grants from the Hellenic Society of Cardiology (2005, 2006) and the Greek General Secretariat of Research and Technology (2006-8). He received awards for his research in Congenital Heart Disease by the Hellenic Society of Cardiology (2003) and in Heart Failure by the European Society of Cardiology (2003). He is a Fellow of the European Society of Cardiology, the European Associations of Echocardiography, Heart Failure and Cardiac Prevention and Rehabilitation. He is also nucleus member of the Hellenic Society of Cardiology Working Group of Heart Failure. He has also worked as a Consultant Cardiologist in major Pharmaceutical Companies and Clinical Research Organizations.

Selected Publications

Neurohormonal Activity and Vascular Properties late after Aortic Coarctation repair. Moutafi AC, Alissafi T, Chamakou A, Chryssanthakopoulos S, Thanopoulos V, Dellos C, Xanthou G, Tousoulis D, Stefanadis C, Gatzoulis MA, Davos CH. Intern J Cardiol 2011 (in press).

Heart Rate Turbulence in Adults with Repaired Tetralogy of Fallot. Davos CH, Moutafi AC, Alexandridi A, Petropoulou E, Varela E, Chamakou AC, Francis D, Kilner P, Piepoli MF, Gatzoulis MA. Intern J Cardiol 2009;135:308-14.

Desmin is a Target and Mediator of TNF-α Induced Aggregate Formation and Intercalated Disk Reorganization. Panagopoulou P, Davos CH, Milner DJ, Varela E, Rapti K, Cameron J, Mann DL, Capetanaki Y. J Cell Biol 2008 181:761-75.

Heart transplantation in heart failure: The prognostic importance of body mass index at time of surgery and subsequent weight changes.  Clark AL, Knosalla C, Birks E, Loebe M, Davos CH, Tsang S, Negassa A, Yacoub M, Hetzer R, Coats AJ, Anker SD.  Eur J Heart Fail. 2007;9:839-44

Statin use and survival in patients with chronic heart failure - results from two observational studies with 5200 patients.  Anker SD, Clark AL, Winkler R, Zugck C, Cicoira M, Ponikowski P, Davos CH, Banasiak W, Zardini P, Haass M, Senges J, Coasts AJ, Poole-Wilson P, Pitt B.  Int J Cardiol 2006;112:234-42.

ExTraMATCH: Exercise Training Meta-Analysis of Trials in Chronic Heart failure patients. Reduction in mortality and hospitalization.  Piepoli MF, Davos CH, Francis D, Coats AJS.  Brit Med J 2004;328:

Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity.  Davos CH, Doehner W, Rauchhaus M, Cicoira M, Francis DP, Coats AJ, Clark AL, Anker SD. J Card Fail 2003;9:29-35.

Global impairment of cardiac autonomic nervous activity late after the Fontan operation.  Davos CH, Francis DP, Leenarts MFE, Yap SC, Li W, Davlouros PA, Wensel R, Coats AJS, Piepoli M, Sreeram N, Gatzoulis MA.  Circulation 2003;108:180-5.

Global impairement of cardiac autonomic nervous activity late after repair of Tetralogy of Fallot.  Davos CH, Davlouros PA, Wensel R, Francis D, Davies LC, Kilner PJ, Coats AJS, Piepoli M, Gatzoulis MA.  Circulation 2002;106:69-75.

Uric acid in cachectic and non-cachectic patients with chronic heart failure: Relationship to leg vascular resistance.  Doehner W, Raucchaus M, Florea VG, Sharma R, Bolger AP, Davos CH, Coats AJS, Anker SD.  Am Heart J 2001; 141(5): 792-9.

Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance. Marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis. Ponikowski P, Francis DP, Piepoli MF, Davies C, Chua TP, Davos CH, Florea V, Banasiak W, Poole-Wilson PA, Coats AJS, Anker SD.  Circulation 2001; 103: 967-72.

Plasma cytokine parameters and mortality in patient with chronic heart failure.  Raucchaus M, Doehner W, Francis DP, Davos CH, Kemp M, Liebenthal C, Niebauer J, Hooper J, Volk H-D, Coats AJS, Anker SD.  Circulation 2000; 102: 3060-7.

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