Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

George Th. George Th. Tsangaris, PhD
Staff Research Scientist - Professor Level

Telephone : +30 210 6597 075
Fax : +30 210 6597 498
e-mail : gthtsangaris@bioacademy.gr


Center :

Systems Biology

Core Facility Site :

Proteomics


Brief Bio

Dr. George Th. Tsangaris was born in Chios, Greece. He holds a degree in Chemistry at 1983 from the Department of Chemistry, University of Ioannina (Ioannina, Greece) and a PhD in Biochemistry from the same University at 1991. From 1991 to 1993 he was post-doctoral fellow of French Government at INSERM U200 (Paris, France) with research interests in Molecular Biology, Molecular Immunology and Immunotoxicology. Dr. Tsangaris stayed in the same Unit of INSERM as researcher up to 1994. From 1994, he returned to Greece and joined the University Research Institute of Genetic and Malignant Diseases (University of Athens, Greece) as principal investigator, responsible for the project “Molecular Study of Childhood cancer”. In parallel as research fellow he joined the Hematology Unit, First Department of Pediatrics, School of Medicine, University of Athens (Athens, Greece).  In 2002, he joined the Roche Centre for Medical Genomics (Basel, Swiss) for sabbatical studies in proteomics, and from 2003 he joined the Proteomics Research Unit of the Biomedical Research Foundation of the Academy of Athens as a Professor Level Research Scientist. Dr. Tsangaris recent work is contributed to the extensive application of proteomics in human pathology with special interest: a) the study of human reproduction and specially the identification of biomarkers for the non-invasive prenatal diagnosis of pregnancy complications, b) the molecular study of cancer with special interest the childhood cancer (brain tumors, hematological malignancies etc) and other types of adult cancers (lymphomas, melanomas etc), and c) neuroproteomics. Dr. Tsangaris has published more than 60 research papers in international peer reviewed journals, 6 articles in Greek journals, 15 review articles, 4 chapters and many presentations and abstracts in international and Greek congresses. Additionally, Dr. Tsangaris is owner of 5 Greek and 2 European patents, and his research work has many international and Greek awards. Further, he is member of the Scientific Advisory Board of the International Institute of Anticancer Research, he is founded member and president of the Hellenic Proteomics Society, founded member and local representative of the European Preventive, Predictive and Personalized Medicine Association, member of the editorial board of three international Journals and reviewer of many other.

Selected Publications

Tsangaris, G.T., El Azzouzi, B., Pellegrini, O., Manuel, Y., Benveniste, J., and Thomas, Y. (1994). Cadmium induces apoptosis in a human T-Cell line. Toxicology, 88: 127-139.

Tsangaris, G.T. and Tzortzatou-Stathopoulou, F. (1998). Cadmium induces apoptosis differentially on immune system cell lines. Toxicology, 128 (2): 143-150.

Tsangaris, G.T. and Tzortzatou-Stathopoulou, F. (1998). Metallothionein expression prevents apoptosis: A study with antisense phosphorothioate oligodeoxynucleotides in a human T Cell line. Anticancer Research, 18 (4A): 2423-2433.

Tsangaris, G.T.,  Karamessinis, P., Kolialexi, A., Garbis, S.D., Antsaklis, A., Mavrou, A. and  Fountoulakis, M. (2006). Proteomic analysis of amniotic fluid in pregnancies with Down Syndrome. Proteomics, 6 (15): 4410-4419.

Mavrou, A., Anagnostopoulos, A., Kolialexi, A., Vougas, K., Papantoniou, N., Antsaklis, A., Fountoulakis, M. and Tsangaris, G.T. (2008). Proteomic analysis of amniotic fluid in pregnancies with Turner syndrome fetuses. Journal of Proteome Research, 7 (5):1862-1866.

Kolialexi, A., Tsangaris, G.T., Papantoniou, N., Anagnostopoulos, A.K., Vougas, K., Bagiokos, V., Antsaklis, A. and Mavrou, A. (2008). Application of proteomics for the identification of differentially expressed protein markers for Down syndrome in maternal plasma. Prenatal Diagnosis, 28 (8): 691-698.

Samara A, Vougas K, Papadopoulou A, Baloyianni N, Chroussos G and Tsangaris GT. (2011). Proteomics reveal hippocampal lateral asymmetry. Hippocampus, 21(1): 108-119.

Anagnostopoulos AK, Dimas KS, Papathanassiou C, Braoudaki M, Anastasiadou E, Vougas K, Karamolegou K, Kontos H, Prodromou N, Tzortzatou-Stathopoulou F, Tsangaris GT (2011) Proteomics studies of childhood pilocytic astrocytoma. Journal Proteome Research  10(5):2555-2565.

Tsangaris, G.T., Botsonis, A., Politis, I. and Tzortzatou-Stathopoulou, F. (2002). Evaluation of cadmium-induced transcriptome alterations by three color cDNA labelling microarray analysis on a T-cell line. Toxicoclogy, 178: 135-160.

Fountoulakis, M., Tsangaris, G.T., Maris, A. and Lubec, G. (2005). The rat brain hippocampus proteome. Journal of Chromatography B, 819 (1):115-129.

Kolialexi A, Anagnostopoulos AK, Papantoniou N, Vougas K, Antsaklis A, Fountoulakis M, Mavrou A and Tsangaris GT (2010). Potential biomarkers for Turner in maternal plasma: possibility for noninvasive prenatal diagnosis. Journal Proteome Research, 9(10): 5164-5170.

Braoudaki M, Tzortzatou-Stathopoulou F, Anagnostopoulos AK, Papathanassiou C, Vougas K, Karamolegou K and Tsangaris GT (2011). Proteomic analysis of childhood de novo acute myeloid leukemia and myelodysplastic syndrome/AML: correlation to molecular and cytogenetic analyses. Amino Acids, 40(3): 943-951.

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