Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Popi Popi Syntichaki, PhD
Investigator - Assistant Professor Level

Telephone : +30 210 6597 474
e-mail : synticha@bioacademy.gr


Center :

Basic Research

Lab Site :

Syntichaki Lab


Brief Bio

Popi Syntichaki graduated from the Agricultural University of Athens, Department of Crop Production and continued her post-graduate studies at the University of Crete, Department of Biology. Having scholarships from the State Scholarships Foundation (IKY) and the Institute of Molecular Biology and Biotechnology (IMBB) acquired a M.Sc. Degree specialization in molecular plant physiology and a Ph.D. in yeast molecular biology. The doctoral dissertation focused on mechanisms of Chromatin Remodeling and transcriptional activation, in the budding yeast Saccharomyces cerevisiae. Then as a post-doctoral fellow in the laboratory of “Molecular Genetics of the nematode” (IMBB), studied the molecular mechanisms of cell death and ageing in the worm Caenorhabditis elegans. These investigations led to the identification of new factors and pathways that affect both procedures. In 2006, Dr. Syntichaki was elected at the IMBB as Research Scientist B´ with research interests in ageing of the model-organisms C. elegans and S. cerevisiae. In 2007, she was awarded with Starting Grant (Ideas) of the European Research Council (ERC). In 2008 she was elected at the Biomedical Research Foundation of the Academy of Athens (BRFAA) as Principal Investigator-Assistant Professor level, with the main research field in molecular genetics of ageing and stress response using as experimental system the nematode C. elegans.

Selected Publications

Borbolis F., Flessa CM., Roumelioti F., Diallinas G., Stravopodis D. and Syntichaki P. (2017). Neuronal function of the mRNA decapping complex determines survival of Caenorhabditis elegans at high temperature through temporal regulation of heterochronic gene expression. Open Biol. 7: 160313.

Borbolis F. and Syntichaki P. (2015). Cytoplasmic mRNA turnover and ageing. Mech Ageing Dev, 152: 32‐42.

Rousakis A., Vlanti A., Borbolis F., Roumelioti F., Kapetanou M. and Syntichaki P. (2014). Diverse functions of mRNA metabolism factors in stress defense and aging of Caenorhabditis elegans. PLoS ONE, 9: e103365.

Rousakis A., Vlassis A., Vlanti A., Patera S., Thireos G. and Syntichaki P. (2013).The GCN-2 kinase mediates stress response and longevity induced by TOR-inactivation in Caenorhabditis elegans. Aging Cell, 12(5): 742-751.

Fasseas MK, Fasseas C, Mountzouris KC, Syntichaki P. (2012). Effects of Lactobacillus salivarius, Lactobacillus reuteri, and Pediococcus acidilactici on the nematode Caenorhabditis elegans include possible antitumor activity. Appl Microbiol Biotechnol 97(5): 2109-2118.

Syntichaki P. Troulinaki K. and Tavernarakis N. (2007). eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature, 445: 922-926.

Syntichaki P., Samara C. and Tavernarakis N. (2005). The Vacuolar H+-ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Current Biology, 15: 1249-1254.

Syntichaki P., Xu K., Driscoll M. and Τavernarakis N. (2002). Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature, 419: 939-944.

Syntichaki P. and Τavernarakis N. (2002). Death by necrosis: Uncontrollable catastrophe, or is there order behind the chaos. EMBO reports, 3: 604-609.

Syntichaki P., Topalidou I. and Thireos G. (2000). The Gcn5 bromodomain co-ordinates nucleosome remodeling. Nature, 404: 414-417.

PubMed:

PubMed Link