BRFAA - Biomedical Research Foundation Academy Of Athens
Biomedical Research Foundation Academy Of AthensAcademy Of Athens

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The main research focus of the Group is the study of the process of ageing. This process is characterized by the progressive age-dependent deterioration of cells, tissues and organs due to the accumulation of damage that results in an overall loss of defensive and homeostatic mechanisms. Ageing is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular and neurodegenerative diseases. Οne of the greatest challenges in biology is defining the biological basis of ageing and understanding the underlying molecular mechanisms and pathways. It is obvious that research on ageing involves studies on the biological function and integration of a plethora of life supporting pathways and offers a unique opportunity to investigate them at a systems level. Moreover, the outcome of ageing research will deliver treatments and interventions that will target the age-related compromise in the quality of life. The Group is using a model system approach to address these issues. The organism used is the worm Caenorhabditis elegans that has proven valuable in identifying the molecular and genetic regulation of ageing and longevity ever since the first long-lived mutant was isolated 30 years ago. The Group is currently focusing its research activities on the role of evolutionary conserved mRNA metabolism factors and mechanisms in the ageing process, stress tolerance and neurodegenerative disorders. The main methodologies are genetic, molecular and biochemical, aiming towards a comprehensive study of the above processes at the organism level in eukaryotes.

Our team is member of the European Network Genie: Group of Elegans new investigators in Europe