Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

George P. George P. Chrousos, MD, MACP, MACE
University Faculty, Affiliated Investigator

Telephone : +30 210 6597 173
Fax : +30 210 6597 545
e-mail : gchrousos@bioacademy.gr


Center :

Clinical, Experimental Surgery & Translational Research

Lab Site :

Chrousos & Charmandari Lab


Brief Bio

Dr. Chrousos is Professor and Chairman of the First Department of Pediatrics at the Athens University Medical School and former Senior Investigator, Director of the Pediatric Endocrinology Section and Training Program, and Chief of the Pediatric and Reproductive Endocrinology Branch of the National Institute of Child Health and Human Development (NICHD), National Institutes of Health. Furthermore, Dr. Chrousos has been Professor of Pediatrics, Physiology and Biophysics at Georgetown University Medical School, Washington DC, USA.

According to the ISI, Dr. Chrousos is among the 200 most prominent clinical investigators in the world. He has authored more than 1000 scientific publications, has edited 23 books and his work has amassed over 40,000 citations.

In his long tenure as a researcher, Dr. Chrousos has focused his research on the hypothalamic-pituitary-adrenal (HPA) axis and has extensively studied the neuroendocrine alterations associated with mood disorders, sleep, pain perception, and immune function.  His clinical and laboratory program is recognized worldwide for its extensive and highly original work on the glucocorticoid signaling system, diseases of the HPA axis, such as Cushing’s syndrome, Addison’s disease, and congenital adrenal hyperplasia, and the physiologic and molecular mechanisms of stress. Early in his career, Dr. Chrousos described in the Journal of Clinical Investigation the Glucocorticoid Resistance Syndrome, a rare but unique and interesting genetic disease of the glucocorticoid receptor that causes hypertension and hyperandrogenism in children and adults. Subsequently, Dr. Chrousos contributed the majority of the international original publications on this syndrome, which has served as a highly informative model of the study of the physiologic functions of these key steroid hormones that regulate the homeostasis of the organism and are critical for its survival.
 
Dr. Chrousos has contributed immensely to the biomedical literature and his work has provided new insights into a spectrum of clinical conditions and disorders that transcend the limits of classical Endocrinology, such as pregnancy, human development, surgical stress, sleep, and septic shock, as well as chronic complex disorders such as depression, eating disorders, and autoimmune –inflammatory diseases. He has an outstanding record of over 1000 scientific papers, has also edited 23 books, including 2 popular electronic volumes and 2 encyclopedias, and his work has been cited in about 40,000 scientific articles, an irrefutable testimony to the importance and influence of his research on international biomedical science and clinical practice. He is one of the most cited physician scientists in the world (Institute of Scientific Information, ISI highly cited) both in the fields of Clinical Medicine and Biology and Biochemistry.  In the ISI highly cited are included the 200 best cited scientists and physicians by field. Clinical Medicine includes all subspecialties of Internal Medicine, Surgery and Laboratory Medicine. Dr. Chrousos’s published work also has an extremely high impact factor of over 5500 and H index of over 100, two other objective markers of worldwide influence in the sciences. Dr. Chrousos has published his work in journals of the highest caliber, such as the New England Journal of Medicine, in which he has a record of over 16 full publications, the Journal of Clinical Investigation, the Annals of Internal Medicine, PNAS, Science and Nature.  
 

Selected Publications

Chrousos G.P., Renquist D., Brandon D., Eil C., Pugeat M., Vigersky R., Cutler G.B., Loriaux D.L., Lipsett M.B. (1982) Glucocorticoid Resistance and Primate Evolution:  Receptor-mediated Mechanisms.  Proc. Natl. Acad. Sci. 179: 2036-2040.

Chrousos G.P., Vingerhoeds A., Brandon D., Pugeat M., Eil C., Loriaux D.L., Lipsett M.B. (1982) Primary Cortisol Resistance in Man:  A Glucocorticoid Receptor-mediated Disease. J. Clin. Invest. 69: 1261-1269.

Chrousos G.P., Schulte H.M., Oldfield E.H., Gold P.W., Cutler G.B. Jr., Loriaux D.L. (1984) The Corticotropin Releasing Factor Stimulation Test:  An Aid in the Differential Diagnosis of Cushing's Syndrome.  N. Engl. J. Med. 310: 622-627.

Gold P.W., Gwirtzman H., Avgerinos P., Nieman L.K., Gallucci W.T., Kaye W., Jimerson D., Ebert M., Rittmaster R., Loriaux D.L., Chrousos G.P. (1986) Abnormal Hypothalamic-pituitary-Adrenal Function in Anorexia Nervosa:  Pathophysiologic Mechanisms in Underweight and Weight-corrected Patients.  N. Engl. J. Med. 314:
1335-42.

Udelsman R., Gallucci W.T., Ramp J., Goldstein D.S., Lipford R., Norton J.A., Loriaux D.L., Chrousos G.P. (1986) Adaptation during Surgical Stress:  A Reevaluation of the Role of Glucocorticoids.  J. Clin. Invest. 77: 1377-1381.

Luger A., Deuster P., Kyle S.B., Gallucci W.T., Montgomery L.C., Gold P.W., Loriaux D.L., Chrousos G.P. (1987)  Acute Hypothalamic-pituitary-adrenal Responses to the Stress of Treadmill Exercise:  Physiologic Adaptations to Physical Training.  N. Engl. J. Med. 316: 1309-1315.

Calogero A., Gallucci W.T., Gold P.W., Chrousos G.P. (1988) Multiple Regulatory Feedback Loops on Hypothalamic Corticotropin Releasing Hormone Secretion.  J. Clin. Invest. 82: 767-774.

Hurley D., Accilli D., Stratakis C., Karl M., Vamvakopoulos N., Rorer E., Constantine K., Taylor S., Chrousos G.P. (1991) Mutation of the Glucocorticoid Receptor Gene in Familial Glucocortcoid Resistance. J. Clin. Invest. 87: 680-686.

Karalis C., Sano H., Redwine J., Listwak S., Wilder R., Chrousos G.P. (1991) Autocrine or Paracrine Inflammatory Actions of Corticotropin Releasing Hormone In Vivo.  Science 254: 421-423.

Vamvakopoulos N.C., Chrousos G.P. (1993) Evidence of Direct Estrogen Regulation of Human Corticotropin Releasing Hormone Gene Expression: Potential Implications for the Sexual Dimorphism of the Stress Response and Immune/Inflammatory Reaction. J. Clin. Invest. 92: 1896-1902.

Tsigos C., Arai K., Hung W., Chrousos G.P. (1993) Hereditary Isolated Glucocorticoid Deficiency is Associated with Abnormalilties of the Adrenocorticotropin Receptor Gene. J. Clin. Invest. 92: 2461-2485.

Magiakou M.A., Mastorakos G., Oldfield E.H., Gomez M.T., Doppman J.L., Cutler G.B. Jr., Nieman L.K., Chrousos G.P. (1994) Cushing Syndrome in Children and Adolescents: Presentation, Diagnosis and Therapy.  N. Engl. J. Med. 331: 629-36.

PubMed:

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