Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Stelios Stelios Psarras, PhD
Staff Research Scientist - Associate Professor Level

Telephone : +30 210 6597 0455
Fax : +30 210 6597 545
e-mail : spsarras@bioacademy.gr


Center :

Basic Research

Lab Site :

Psarras Lab

Core Facility Site :

Histochemistry


Brief Bio

Stelios Psarras’ research activities focus on the study of tissue remodeling mechanisms and their contribution to the pathologies of basic organs (e.g. heart, lung).

In particular, he studies the characteristics of the inflammatory responses caused by intrinsic (e.g. de-regulated cell death) or extrinsic (e.g. viral or microbial infections) factors and the associated induction of adverse tissue remodelling features, such as extended fibrosis and angiogenesis. To that end, he is employing genetic and induced animal models of heart and renal failure and post-infection asthma, as well as relevant cell culture systems. Special emphasis is given to the contribution of inflammatory cells such as the macrophages, as well as their interaction with stromal cells to the progress and regulation of particular pathogenic states (e.g. heart failure, asthma). Using whole gene expression analysis he also aims to identify key molecular players which may serve both as biomarkers or modulators of the respective diseases. His ultimate goal will be the application of therapeutic interventions based on the understanding of common and unique mechanisms underlying adverse tissue remodeling and dysfunction of different organs that will modify and activate or inhibit particular cell populations such as monocytes/macrophages and stem or progenitor cells.

Stelios Psarras is a National and Capodistrian University of Athens (NCUA) Chemist (Diploma in 1986), and conducted his PhD work in N.C.S.R. “Demokritos” (Dr. Stathakos lab) with a fellowship from the Greek Atomic Energy Commission (PhD obtained from NCUA Dept. of Biology in 1996). He was a post-doctoral fellow (1997-1999) in Dr. K. Khazaie’s group in DKFZ, Heidelberg, Germany [Cellular Immunology Dept. 0710, Tumor Immunology Programme, Dir: Prof. Volker Schirrmacher], with a Schering AG fellowship, and in Faculté de Médecine Necker Enfants-Malades, Paris, France [Unité INSERM 373, Dir: Prof. Harald von Boehmer], with a “post-vert” INSERM fellowship. During 2000-2004 he was Research Associate at the 2nd Pediatric Department, NCUA (Dr. NG Papadopoulos group). From 2004 to 2008 he was Scientific collaborator and senior post-doctoral researcher at BRFAA (Dr. Yassemi Capetanaki group), whereas since August 2008 he is Staff Research Scientist (Associate Professor Level) at the Histochemistry Core Facility, Histology Dept., BRFAA. He has actively participated in numerous funded research activities as senior collaborator and he is currently being funded for his own research.

During his research work Stelios Psarras applied and/or developed a number of tools and techniques aiming to facilitate monitoring and analysis of tissue pathology and function and intervention studies. His expertise include histological analysis and cell population characteristics (histochemistry, in situ hybridization, immunohistochemistry, flow cytometry), tissue pathology analysis of animal models (e.g. heart failure), primary cultures from biopsy material and study of remodeling features, holistic and partial gene expression analysis, design and generation of viral vectors for gene transfer, detection and pathophysiology of viral and microbial infections etc.

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Selected Publications

Skevaki CL, Psarras S, Volonaki E, Pratsinis H, Spyridaki IS, Gaga M, Georgiou V, Vittorakis S, Telcian AG, Maggina P, Kletsas D, Gourgiotis D, Johnston SL, Papadopoulos NG. Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling features. Clin Transl Allergy, 21;2(1):14, 2012

Psarras S, Mavroidis M, Sanoudou D, Davos CH, Xanthou G, Varela AE, Panoutsakopoulou V, Capetanaki Y. Regulation of adverse remodelling by osteopontin in a genetic heart failure model. Eur Heart J, 33, 1954-1963, 2012, 2011 Apr 26, [Epub ahead of print]

Georgiadou E, Iliodromitis K, Mavroidis M, Kolokathis F, Andreadou I, Psarras S, Capetanaki Y, Boudoulas H, Kremastinos D. Relationship between plasma osteopontin and oxidative stress in patients with coronary artery disease. Expert Opin Ther Targets 12, 917-20, 2008

Kypreou KP, Kavvadas P, Karamessinis P, Peroulis M, Alberti A, Sideras P, Psarras S, Capetanaki Y, Politis PK, Charonis AS. Altered expression of calreticulin during the development of fibrosis. Proteomics, 8, 2407, 2008

Psarras S, Volonaki E, Skevaki, C, Hatzipsalti M, Bossios A, Pratsinis H, Tsigkos S, Gourgiotis D, Constantopoulos AG, Papapetropoulos A, Saxoni-Papageorgiou P, Papadopoulos NG. VEGF-mediated induction of angiogenesis by human rhinoviruses: a link by viral infection and airway remodelling in asthma. J Allergy Clin Immunol 117, 291-297, 2006

Volonaki E, Psarras S, Xepapadaki P, Psomali D, Gourgiotis D, Papadopoulos NG Synergistic effects of fluticasone propionate and salmeterol on inhibiting rhinovirus-induced epithelial production of remodelling-associated growth factors Clin Exp Allergy, 36, 1268-1273, 2006

Psarras S, Karagianni N, Kellendock C, Tronche F, Cosset F-L, Stocking C, Schirrmacher V, von Boehmer H. and Khazaie K. Gene transfer and genetic modification of ES cells by Cre and Cre-PR expressing MESV based retroviral vectors. J Gene Med, 6, 32-42, 2004

Klein, L., Trautman, L., Psarras, S., Schnell, S., Siermann, A., Liblau, R., von Boehmer, H. and Khazaie, K. Visualizing the course of antigen-specific CD8 and CD4 T cell responses to a growing tumor. Eur J Immunol. 33, 806-814, 2003.

Tsolia MN, Psarras S, Bossios A, Audi H, Paldanius M, Gourgiotis D, Kallergi K, Kafetzis DA, Konstantopoulos A, Papadopoulos NG “Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections” Clin Infect Dis, 39, 681-686, 2004

Xepapadaki P, Psarras S, Bossios A, Tsolia M, Gourgiotis D, Constantopoulos AG, Kafetzis D. and Papadopoulos NG. Human metapneumovirus as a causative agent of acute bronchiolitis in infants. J Clin Virol 30, 267-270, 2004.

Xatzipsalti M, Kyrana S, Tsolia M, Psarras S, Bossios A, Laza-Stanza V, Johnston SL, Papadopoulos NG. Rhinovirus viremia in children with respiratory infections. Am J Resp Crit Care Med, 172, 1037-1040, 2005

Karagianni N, Ly M-C, Psarras S, Chlichlia K, Gounari F and Khazaie K. Identification of a new promoter for the mouse adenomatous polyposis coli (APC) gene Genomics 85, 231-237, 2005

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