Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

George M. George M. Spyrou, PhD
Staff Research Scientist - Professor Level

Telephone : +30 210 6597 151
Fax : +30 210 6597 545
e-mail :

Center :

Systems Biology

Brief Bio

George Spyrou received his BSc on Physics from National and Kapodistrian University of Athens. Afterwards he received Master of Sciences on Medical Physics from University of Patras where he completed also his PhD on Medical Physics, working on algorithms and simulations applied on medical issues, especially on breast cancer imaging. Trying to get in the field of Bioinformatics, Spyrou received also a Master of Sciences on Bioinformatics from the Department of Biology in the National and Kapodistrian University of Athens .Since 1994 he has joined as Research Associate the Medical Imaging Research Group of HEPA (High Energy Physics & Applications) Lab in the Physics Dept of University of Athens, working in the project of the small animal PET (Positron Emission Tomography) prototype design and construction. Since 1998 Spyrou collaborates with the Informatics Laboratory of the Academy of Athens in the research project "Ippokratis-mst" applying medical image analysis techniques and developing decision support systems for the early detection and diagnosis of breast cancer. The developed prototype had been selected from General Secretariat of Research and Technology of Greece as a major achievement among others to participate in the 2005 Exhibition Week of Science and Technology organized by the Greek Ministry of Development. Since 2001 George Spyrou is working as Research Scientist on Medical Physics and Informatics in the Biomedical Research Foundation of the Academy of Athens. Also, he has been assigned as the Head of the Department of Informatics and New Technologies in the Foundation. His main objectives are the design and coordination of the Information Technology infrastructure as well as the preparation of the newly established Biomedical Informatics Research Unit. In parallel, Spyrou teaches simulation methods and informatics (aplied or not) into two postgraduate courses as well as in the National School of Public Administration and Local Government. The main aim of Spyrou is the application of his knowledge and skills in Physics, Mathematics and Informatics to medically and biologically relevant issues, mainly on the 'mining' of the information either in direct medical data (e.g. medical images) or in genomes and proteomes relevant to medical problems.

Selected Publications

Bourdakou MM, Athanasiadis EI, Spyrou GM. Discovering gene re-ranking efficiency and conserved gene-gene relationships derived from gene co-expression network analysis on breast cancer data. Scientific Reports 2016 Feb 19;6:20518. doi:10.1038/srep20518.

Siavelis JC, Bourdakou MM, Athanasiadis EI, Spyrou GM, Nikita KS. Bioinformatics methods in drug repurposing for Alzheimer's disease. Brief Bioinform. 2015 Jul 21.

Eleftheriou SV, Bourdakou MM, Athanasiadis EI, Spyrou GM. GeneStoryTeller: a mobile app for quick and comprehensive information retrieval of human genes. Database (Oxford). 2015 Jun 8;2015:bav048.

Athanasiadis EI, Antonopoulou K, Chatzinasiou F, Lill CM, Bourdakou MM, Sakellariou A, Kypreou K, Stefanaki I, Evangelou E, Ioannidis JP, Bertram L, Stratigos AJ, Spyrou GM. A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools. Database (Oxford). 2014 Nov 7;2014.

Andreadis II, Spyrou GM, Nikita KS. A CADx scheme for mammography empowered with topological information from clustered microcalcifications' atlases. IEEE J Biomed Health Inform. 2015 Jan;19(1):166-73.

Paraskevopoulou MD, Vlachos IS, Athanasiadis E, Spyrou G.,"BiDaS: a web-based Monte Carlo BioData Simulator based on sequence/feature characteristics." Nucleic Acids Res. 2013 Jul;41(Web Server issue):W582-6. doi: 10.1093/nar/gkt420.

Sakellariou A, Sanoudou D, Spyrou G. Combining multiple hypothesis testing and affinity propagation clustering leads to accurate, robust and sample size independent classification on gene expression data. BMC Bioinformatics. 2012 Oct 17;13(1):270

Athanasiadis E, Cournia Z and Spyrou G, “ChemBioServer: A web-based pipeline for filtering, clustering and visualization of chemical compounds used in drug discovery”, Bioinformatics, 2012, doi: 10.1093/bioinformatics/bts551

Alexandridou A, Dovrolis N, Tsangaris GT, Nikita K, Spyrou G. “PepServe: a web server for peptide analysis, clustering and visualization”, Nucleic Acids Res. 2011 Jul;39(Web Server issue):W381-4.

Anastasia Alexandridou, George Th. Tsangaris, Konstantinos Vougas, Konstantina Nikita and George Spyrou, “UniMaP: Finding Unique Mass and Peptide signatures in the Human Proteome”, Bioinformatics, 2009 Nov 15;25(22):3035-7

Anastasia Alexandridou, George Th. Tsangaris, Konstantinos Vougas, Konstantina Nikita and George Spyrou, “Peptide Finder: Mapping measured molecular masses to peptides and proteins”, Bioinformatics, 2008 Oct 1;24(19):2267-9

G. Spyrou, S. Kapsimalakou A. Frigas K. Koufopoulos S. Vassilaros P. Ligomenides “"Hippocrates-mst": A prototype for Computer-Aided Microcalcification Analysis and Risk Assessment for Breast Cancer", Medical & Biological Engineering & Computing, 2006 Nov;44(11):1007-15


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