Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Research Highlights :Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies

 

 

 

 

Panagiotis Politis, Dimitris Gkikas and colleagues recently published a study in PNAS

 

 

Glioblastomas and neuroblastomas are aggressive cancer types with poor prognosis. Identification of druggable factors that inhibit these tumors will contribute to new therapies. Our data show that nuclear receptor NR5A2 suppresses the growth of glioblastomas and neuroblastomas. This function is facilitated by the ability of NR5A2 to induce critical cell cycle inhibitors including p21, p27, and Prox1. Most importantly, we show that two small molecule agonists of NR5A2, DLPC and DUPC, can mimic its antitumor effect as well as to strongly inhibit the growth of glioblastoma tumors in animal models. Our results identify NR5A2 as a potential drug target in nervous system–related cancers.


Gkikas D, Stellas D, Polissidis A, Manolakou T, Kokotou MG, Kokotos G, Politis PK
Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2015243118. doi: 10.1073/pnas.2015243118
PMID: 34561301

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