Katsouda et al. describe the impact of the sulfide species–generating enzyme MPST in energy homeostasis and metabolic health. Mpst−/− mice placed on high-fat diet exhibit attenuated mitochondrial protein import, mitochondrial dysfunction, enhanced lipid accumulation, adipocyte enlargement, and excessive weight gain. Therapeutic sulfide administration ameliorates obesity-related molecular and phenotypic changes.
MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity
Katsouda A, Valakos D, Dionellis VS, Bibli SI, Akoumianakis I, Karaliota S, Zuhra K, Fleming I, Nagahara N, Havaki S, Gorgoulis VG, Thanos D, Antoniades C, Szabo C, Papapetropoulos A. J Exp Med. 2022 Jul 4;219(7):e20211894. doi: 10.1084/jem.20211894. Epub 2022 May 26.PMID: 35616614