Vassilis Gorgoulis and colleagues recently published a study in Genome Biology

In a continuation of their previous publication in Nat Cell Biol 2016, Vassilis G. Gorgoulis and colleagues published a study in Genome Biology. In this new work the authors, guided by mutational signatures, define how error-prone DNA repair mechanisms craft the genome leading to instability and cancer progression. Their work signifies the importance that mutational signatures can have in guiding cancer therapy with potential implications in personalized medicine.

Pubmed

Genome Biology
Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG. Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.