Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion - Research Highlights - BRFAA - Biomedical Research Foundation Academy Of Athens

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Research Highlights :Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion

Katia Karalis and colleagues recently published a new study in Cell Reports

The conserved Notch signaling pathway is required for adult tissue homeostasis. Billiard et al. show that Dll4-Notch signaling inhibition supports the health of β-islet cells and affects insulin production by driving differentiation of insulin-producing cell progenitors and blockade of islet apoptosis.

Fabienne Billiard, Sevasti Karaliota, Bei Wang, Dimitrios Stellas, Ioannis Serafimidis, Antigoni Manousopoulou, Yiassemi Koutmani, Elpiniki Ninou, Jacquelynn Golubov, Amanda DaNave, Panagiotis Tsakanikas, Yurong Xin, Wen Zhang, Matthew Sleeman, George D. Yancopoulos, Andrew J. Murphy, Spiros D. Garbis, Katia Karalis, Dimitris Skokos.

Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion.

Cell Reports. 2018 January. 22(4): 895-904. doi:10.1016/j.celrep.2017.12.076

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