Scientific Personnel

Brief Bio

Dr. Manolis Mavroidis studied Biology at the University of Patras, Greece, from where he graduated in 1991. He received his Ph.D. in Molecular Biology from the University of Patras, Greece in 1997. From 1992 to 1994 he worked as Research specialist at Medical School, University of Pennsylvania, USA in Dr’s J. D. Lambris laboratory, where he contacted the experimental part of his thesis, in the study of the complement system. His post-doctoral studies initially were conducted at the Division of Hematology and transfusion Medicine, Medical School, University of Patras Greece (1998) and then at the Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA (1999-2002) in Dr’s Y. Capetanaki laboratory studying the role of intermediate filament cytoskeleton in cardiomyopathy and heart failure development. He was appointed (2003) as Researcher D (Lecturer) at the Cell Biology Division in the Center for Basic Research of the Biomedical Research Foundation, Academy of Athens, Greece.

His research is focused in studying cardiomyopathy/heart failure development trying to identify targets for intervention and biomarkers of the disease. More specifically using the desmin deficient and other cytoskeleton related cardiomyopathy mice models, he tries to elucidate:
    
1) At cellular level, the role of the muscle specific intermediate filament desmin in the structure/function of cardiomyocyte structures like intercalated discs and z-discs and their role in the development of dilated cardiomyopathy.
2) At cardiac tissue level:
a)    The role of inflammatory reaction (innate immunity) in heart failure development.
b)    The role of cytoskeleton in cardiac conduction system structure and function and its role in arrhythmias and sudden cardiac death.
 

Selected Publications

Desmin is essential for the structure and function of the sinoatrial node: implications for increased arrhythmogenesis.
Mavroidis M, Athanasiadis NC, Rigas P, Kostavasili I, Kloukina I, Te Rijdt WP, Kavantzas N, Chaniotis D, van Tintelen JP, Skaliora I, Davos CH. Am J Physiol Heart Circ Physiol. 2020 Sep 1;319(3):H557-H570. doi: 10.1152/ajpheart.00594.2019. Epub 2020 Jul 17. PMID: 32678709

Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease.
Chasapis CT, Makridakis M, Damdimopoulos AE, Zoidakis J, Lygirou V, Mavroidis M, Vlahou A, Miranda-Vizuete A, Spyrou G, Vlamis-Gardikas A. Free Radic Biol Med. 2019 Jun;137:59-73. doi: 10.1016/j.freeradbiomed.2019.04.018. Epub 2019 Apr 21. PMID: 31018154

Intermediate filaments in cardiomyopathy.
Tsikitis M, Galata Z, Mavroidis M, Psarras S, Capetanaki Y. Biophys Rev. 2018 Aug;10(4):1007-1031. doi: 10.1007/s12551-018-0443-2. Epub 2018 Jul 19. PMID: 30027462 Free PMC article. Review.

The neuroprotective agent Rasagiline mesylate attenuates cardiac remodeling after experimental myocardial infarction.
Varela A, Mavroidis M, Katsimpoulas M, Sfiroera I, Kappa N, Mesa A, Kostomitsopoulos NG, Cokkinos DV. ESC Heart Fail. 2017 Aug;4(3):331-340. doi: 10.1002/ehf2.12140. Epub 2017 Mar 12. PMID: 28772050 Free PMC article.

Strategies to Study Desmin in Cardiac Muscle and Culture Systems.
Diokmetzidou A, Tsikitis M, Nikouli S, Kloukina I, Tsoupri E, Papathanasiou S, Psarras S, Mavroidis M, Capetanaki Y. Methods Enzymol. 2016;568:427-59. doi: 10.1016/bs.mie.2015.09.026. Epub 2015 Nov 3. PMID: 26795479

Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy.
Mavroidis M, Davos CH, Psarras S, Varela A, C Athanasiadis N, Katsimpoulas M, Kostavasili I, Maasch C, Vater A, van Tintelen JP, Capetanaki Y. Basic Res Cardiol. 2015 May;110(3):27. doi: 10.1007/s00395-015-0485-6. Epub 2015 Apr 8. PMID: 25851234

Complement system activation in cardiac and skeletal muscle pathology: friend or foe?
Syriga M, Mavroidis M. Adv Exp Med Biol. 2013;735:207-18. doi: 10.1007/978-1-4614-4118-2_14. PMID: 23402029 Review.

Regulation of adverse remodelling by osteopontin in a genetic heart failure model.
Psarras S, Mavroidis M, Sanoudou D, Davos CH, Xanthou G, Varela AE, Panoutsakopoulou V, Capetanaki Y. Eur Heart J. 2012 Aug;33(15):1954-63. doi: 10.1093/eurheartj/ehr119. Epub 2011 Apr 26. PMID: 21525025

A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization.
Mavroidis M, Panagopoulou P, Kostavasili I, Weisleder N, Capetanaki Y. FASEB J. 2008 Sep;22(9):3318-27. doi: 10.1096/fj.07-088724. Epub 2008 Jun 6. PMID: 18539904 Free PMC article.

Proper perinuclear localization of the TRIM-like protein myospryn requires its binding partner desmin.
Kouloumenta A, Mavroidis M, Capetanaki Y. J Biol Chem. 2007 Nov 30;282(48):35211-21. doi: 10.1074/jbc.M704733200. Epub 2007 Sep 14. PMID: 17872945

Muscle intermediate filaments and their links to membranes and membranous organelles.
Capetanaki Y, Bloch RJ, Kouloumenta A, Mavroidis M, Psarras S. Exp Cell Res. 2007 Jun 10;313(10):2063-76. doi: 10.1016/j.yexcr.2007.03.033. Epub 2007 Apr 3. PMID: 17509566 Review.

Extensive induction of important mediators of fibrosis and dystrophic calcification in desmin-deficient cardiomyopathy.
Mavroidis M, Capetanaki Y. Am J Pathol. 2002 Mar;160(3):943-52. doi: 10.1016/S0002-9440(10)64916-4. PMID: 11891192 Free PMC article.

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