Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Research Highlights :Crosstalk between coagulation and complement activation promotes cardiac dysfunction in arrhythmogenic right ventricular cardiomyopathy

 

Manolis Mavroidis and colleagues recently published a study in Theranostics

 

These findings provide new insights into the crosstalk between the coagulation and complement systems in the pathogenesis of Arrhythmogenic right ventricular cardiomyopathy  (ARVC). Thus, inhibiting thrombin activation may serve as a feasible strategy for preventing and/or reducing myocardial injury in patients with ARVC. Moreover, our finding that increased serum levels of sC5b9 are associated with cardiac dysfunction and may predict death/transplant events in patients suggests that serum sC5b9 may serve as a possible biomarker for predicting disease progression and outcome in ARVC.

Model depicting the putative crosstalk between the complement and coagulation systems as a new pathogenetic mechanism that exacerbates myocardial injury in ARVC.

 


Crosstalk between coagulation and complement activation promotes cardiac dysfunction in arrhythmogenic right ventricular cardiomyopathy
Jie Ren, Konstantinos Tsilafakis, Liang Chen, Konstantinos Lekkos, Ioanna Kostavasili, Aimilia Varela, Dennis V. Cokkinos, Constantinos H. Davos, Xiaogang Sun, Jiangping Song and Manolis Mavroidis
Theranostics 2021; 11(12): 5939-5954. doi:10.7150/thno.58160

pubmed