Biomedical Ίδρυμα Ιατροβιολογικών Ερευνών, Ακαδημίας ΑθηνώνΑκαδημία Αθηνών
Επιστημονικά Επιτεύγματα :A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

 

Vassilis G. Gorgoulis and colleagues recently published a study in Molecular Cell

The authors provide evidence on how senescent cells escape from oncogene induced senescence, an important tumor suppressor mechanism, facilitating tumor progression. Particularly they demonstrate that a recurrent chromosomal inversion harboring the circadian gene BHLHE40 is sufficient to drive escape from oncogene-induced senescence. The inversion is the outcome of oncogene/replication stress-mediated genomic instability followed by chromatin refolding changes that activate the gene, leading to cell cycle re-entry and aggressive behavior. These findings support that replication stress-induced genomic instability is the causative factor underlying ‘‘escape’’ from oncogene-induced senescence and that targeting senescent cells with senolytic drugs can be of major clinical importance by eliminating a potential source of recurrence.

 


pubmed

A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
Zampetidis CP, Galanos P, Angelopoulou A, Zhu Y, Polyzou A, Karamitros T, Kotsinas A, Lagopati N, Mourkioti I, Mirzazadeh R, Polyzos A, Garnerone S, Mizi A, Gusmao EG, Sofiadis K, Gál Z, Larsen DH, Pefani DE, Demaria M, Tsirigos A, Crosetto N, Maya-Mendoza A, Papaspyropoulos A, Evangelou K, Bartek J, Papantonis A, Gorgoulis VG.
Mol Cell. 2021 Nov 12:S1097-2765(21)00909-6. doi: 10.1016/j.molcel.2021.10.017.