Vassilis G. Gorgoulis and colleagues recently published a study in EMBO Reports

The title of the study is "RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1". In this study, Papaspyropoulos et al. show that the RASSF1A tumor suppressor uncouples the NOTCH-HES1 axis by triggering SNURF/RNF4-mediated HES1 ubiquitination. Loss of RASSF1A promotes cancer stemness via NOTCH-independent HES1 stabilization and confers resistance to γ-secretase inhibitors (GSI). This is the first evidence of crosstalk between the Hippo and Notch pathways, through the RASSF1A tumor suppressor. The study provides insight into the clinical setting where the use of GSIs constitutes a productive therapeutic approach in oncology.

pubmed

RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1
Papaspyropoulos A, Angelopoulou A, Mourkioti I, Polyzou A, Pankova D, Toskas K, Lanfredini S, Pantazaki AA, Lagopati N, Kotsinas A, Evangelou K, Chronopoulos E, O'Neill E, Gorgoulis V.
EMBO Rep. 2021 Dec 13:e51287. doi: 10.15252/embr.202051287.