Biomedical Ίδρυμα Ιατροβιολογικών Ερευνών, Ακαδημίας ΑθηνώνΑκαδημία Αθηνών
Επιστημονικά Επιτεύγματα :CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus


Katia Catherine Karalis and Colleagues recently published a study in Cell Reports

Katia Catherine Karalis and colleagues (Yassemi Koutmani and Katia P. Karalis are co-coresponding authors) recently published in Cell Reports a study demonstrating a novel role for the major stress mediator CRH, in adult neural stem cells homeostasis. Particularly, the authors showed that CRH directly stimulates hippocampal neural stem cells activity through a BMP4-mediated mechanism affecting their responsiveness to environmental stimuli. They also showed conserved expression of CRH/CRHRs system in humans. Since adult hippocampal neurogenesis is involved in important cognitive functions such as memory and learning, this work depicts the CRH/CRH receptors system as a potential therapeutic target for brain disorders.


CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus.
Koutmani Y, Gampierakis IA, Polissidis A, Ximerakis M, Koutsoudaki PN, Polyzos A, Agrogiannis G, Karaliota S, Thomaidou D, Rubin LL, Politis PK, Karalis KP.
Cell Rep. 2019 Oct 22;29(4):932-945.e7. doi: 10.1016/j.celrep.2019.09.037.