The histone variant macroH2A marks specific regions in the genome. Dr. Thanos and colleagues show that a specific subset of promoter-bound macroH2A nucleosomes are stabilized by the transcription factor NRF-1 and reduce the transcriptional variability of target genes.
Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene Expression.
Lavigne MD, Vatsellas G, Polyzos A, Mantouvalou E, Sianidis G, Maraziotis I, Agelopoulos M, Thanos D.
Cell Rep. 2015 May 19;11(7):1090-101. doi: 10.1016/j.celrep.2015.04.022. Epub 2015 May 7.