Publications

Orestis Argyros, Theodoros Karampelas, Xenophon Asvos, Aimilia Varela, Nisar Sayyad, Athanasios Papakyriakou, Constantinos H Davos, Andreas G Tzakos, Demosthenes Fokas, and Constantin Tamvakopoulos. Peptide-drug conjugate GnRH-sunitinib targets angiogenesis selectively at the site of action to inhibit tumor growth. Cancer Res canres.2138.2015; Published OnlineFirst December 8, 2015; doi:10.1158/0008-5472.CAN-15-2138

Stellas D, Szabolcs M, Koul S, Li Z, Polyzos A, Anagnostopoulos C, Cournia Z, Tamvakopoulos C, Klinakis A, Efstratiadis A. (2014) Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer J Natl Cancer Inst. 2014 Oct 11;106(12)

Karampelas T, Argyros O, Sayyad N, Spyridaki K, Pappas C, Morgan K, Kolios G, Millar RP, Liapakis G, Tzakos AG, Fokas D, Tamvakopoulos C.  (2014) GnRH-Gemcitabine Conjugates for the Treatment of Androgen-Independent Prostate Cancer: Pharmacokinetic Enhancements Combined with Targeted Drug Delivery.  Bioconjug Chem. 16;25(4):813-23.

Koltsida O, Karamnov S, Pyrillou K, Vickery T, Chairakaki A-K, Tamvakopoulos C, Sideras P, Serhan CN, Andreakos E (2013) Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation EMBO Mol Med. ;5(5):762-75

Chatziioannou AN, Siskos AP, Loxas D, Kavatzas, N, Agrogiannis G, Fokas D, Malagari K, Kostomitsopoulos N, Tsigkou O, Tamvakopoulos C (2013) Transarterial Embolization with Sorafenib in animal livers: a pharmacokinetic study. J Vasc Interv Radiol. ;24(11):1657-63

Laimou D, Katsila T, Matsoukas J, Schally A, Gkountelias K, Liapakis G, Tamvakopoulos C, Tselios T. (2012) Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: enhanced enzymatic stability and biological properties. Eur J Med Chem. Dec;58:237-47.

Katsila T, Balafas E, Liapakis G, Limonta P, Montagnani Marelli M, Gkountelias K, Tselios T, Kostomitsopoulos N, Matsoukas J, and Tamvakopoulos C (2011) Evaluation of a stable gonadotropin releasing hormone analogue in mice for the treatment of endocrine disorders and prostate cancer.  J Pharmacol Exp Ther. 336 (3):613-23

Anderson R, Franch A, Castell M, Perez-Cano FJ, Bräuer R, Pohlers D, Gajda M, Siskos AP, Katsila T, Tamvakopoulos C, Rauchhaus U, Panzner S, Kinne RW. (2010) Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis. Arthritis Res Ther. 12 (4): R147

Siskos AP, Katsila T, Balafas E, Kostomitsopoulos N, Tamvakopoulos C (2009) Simultaneous Absolute Quantification of the Glucose-Dependent Insulinotropic Polypeptides GIP1-42 and GIP3-42 in Mouse Plasma by LC/ESI-MS/MS: Preclinical Evaluation of DP-IV Inhibitors. J Proteome Res., 8 (7):3487-96.

Garbis SD, Tyritzis SI, Roumeliotis T, Zerefos P, Giannopoulou EG, Vlahou A, Kossida S, Diaz J, Vourekas S, Tamvakopoulos C, Pavlakis K, Sanoudou D, Constantinides CA. (2008) Search for potential markers for prostate cancer diagnosis, prognosis and treatment in clinical tissue specimens using amine-specific isobaric tagging (iTRAQ) with two-dimensional liquid chromatography and tandem mass spectrometry. J Proteome Res. Aug;7(8):3146-58.

Z.D. Sofianos, T. Katsila, N. Kostomitsopoulos, V. Balafas, J. Matsoukas, T. Tselios, and C. Tamvakopoulos (2008) In vivo evaluation and in vitro metabolism of leuprolide in mice—mass spectrometry-based biomarker measurement for efficacy and toxicity J. Mass Spectrom, 43: 1381-1392.

Tamvakopoulos C, Dimas K, Sofianos ZD, Hatziantoniou S, Han Z, Liu ZL, Wyche JH, Pantazis P (2007). Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clin Cancer Res. 13(4):1269-77.

Tamvakopoulos C. (2007) Mass spectrometry for the quantification of bioactive peptides in biological fluids. Mass Spectrom. Reviews 26(3):389-402.

Tamvakopoulos C. (2007) Mass spectrometry for the quantification of bioactive peptides in biological fluids. Mass Spectrom Reviews, 26 (3): 389-402.

Hatziieremia S, Kostomitsopoulos N, Balafas V, Tamvakopoulos C. (2007) A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice. Rapid Commun. Mass Spectrom. 21(15):2431-8.

Shen DM, Zhang F, Brady EJ, Candelore MR, Dallas-Yang Q, Ding VD, Dragovic J, Feeney WP, Jiang G, McCann PE, Mock S, Qureshi SA, Saperstein R, Shen X, Tamvakopoulos C, Tong X, Tota LM, Wright MJ, Yang X, Zheng S, Chapman KT, Zhang BB, Tata JR, Parmee ER (2005) Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists. Bioorg. Med. Chem. Lett. 15(20):4564-9, 2005.

Ye Z, Guo L, Barakat KJ, Pollard PG, Palucki BL, Sebhat IK, Bakshi RK, Tang R, Kalyani RN, Vongs A, Chen AS, Chen HY, Rosenblum CI, Macneil T, Weinberg DH, Peng Q, Tamvakopoulos C, Miller RR, Stearns RA, Cashen DE, Martin WJ, Metzger JM, Strack AM, Macintyre DE, Van der Ploeg LH, Patchett AA, Wyvratt MJ, Nargund RP. (2005) Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist. Bioorg. Med. Chem. Lett. 15:3501-3505.

Bakshi RK, Hong Q, Olson JT, Ye Z, Sebhat IK, Weinberg DH, Macneil T, Kalyani RN, Tang R, Martin WJ, Strack A, McGowan E, Tamvakopoulos C, Miller RR, Stearns RA, Tang W, Maclntyre DE, van der Ploeg LH, Patchett AA, Nargund RP. (2005) 1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists. Bioorg. Med. Chem. Lett. 15:3430-3433.

Palucki BL, Park MK, Nargund RP, Tang R, Macneil T, Weinberg DH, Vongs A, Rosenblum CI, Doss GA, Miller RR, Stearns RA, Peng Q, Tamvakopoulos C, Van der Ploeg LH, Patchett AA. (2005) 2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists. Bioorg. Med. Chem. Lett. 15:1993-1996,

Palucki BL, Park MK, Nargund RP, Ye Z, Sebhat IK, Pollard PG, Kalyani RN, Tang R, Macneil T, Weinberg DH, Vongs A, Rosenblum CI, Doss GA, Miller RR, Stearns RA, Peng Q, Tamvakopoulos C, McGowan E, Martin WJ, Metzger JM, Shepherd CA, Strack AM, Macintyre DE, Van der Ploeg LH, Patchett AA. (2005) Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist. Bioorg. Med. Chem. Lett.15:171-175.

Fenyk-Melody JE, Shen X, Peng Q, Pikounis W, Colwell L, Pivnichny J, Anderson LC, Tamvakopoulos CS. (2004) A comparison of the effects of perfusion in determining brain penetration (brain/plasma ratios) of small molecules in rats. Comp. Med. 54: 378-381.

Zhu L, Tamvakopoulos C, Xie D, Dragovic J, Shen X, Fenyk-Melody JE, Schmidt K, Bagchi A, Griffin PR, Thornberry NA, Sinha Roy R. (2003) The role of dipeptidyl peptidase IV (DP-IV) in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide [1-38]. J Biol Chem. 278 (25), 22418-23.

Van der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, Drisko J, Cashen D, Sebhat I, Patchett AA, Figueroa DJ, DiLella AG, Connolly BM, Weinberg DH, Tan CP, Palyha OC, Pong SS, MacNeil T, Rosenblum C, Vongs A, Tang R, Yu H, Sailer AW, Fong TM, Huang C, Tota MR, Chang RS, Stearns R, Tamvakopoulos C, Christ G, Drazen DL, Spar BD, Nelson RJ, MacIntyre DE. (2002) A role for the melanocortin 4 receptor in sexual function.  Proc Natl Acad Sci U S A. – 99(17), 11381-11386.