BRFAA - Biomedical Research Foundation Academy Of Athens
Biomedical Research Foundation Academy Of AthensAcademy Of Athens


Lam CK, Zhao W, Cai W, Vafiadaki E, Zhang Z, Ren X, Liu Y, Florea S, Zhou X, Min J, Rubinstein J, Jones WK, Kranias EG: Novel Role of HAX-1 in Ischemic Injury Protection: Involvement of Hsp90. Circ Res (In Press)

Florea S, Anjak A, Cai W, Qian J, Vafiadaki E, Figueria S, Haghighi K, Rubinstein J, Lorenz J, Kranias EG: Constitutive phosphorylation of
inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging. Basic Res Cardiol. 107(5):279, 2012.

Combining multiple hypothesis testing and affinity propagation clustering leads to accurate, robust and sample size independent classification on gene expression data. Sakellariou A, Sanoudou D, Spyrou G. BMC Bioinformatics. 2012 Oct 17;13(1):270.

Totary-Jain H, Sanoudou D, Dautriche CN, Schneller H, Zambrana L, Marks AR. Rapamycin resistance is linked to defective regulation of Skp2. Cancer Res. 2012 Apr 1;72(7):1836-43.

Sanoudou D, Mountzios G, Arvanitis DA, Pectasides D. Array-based pharmacogenomics of molecular-targeted therapies in oncology. Pharmacogenomics J. 2012 Jun;12(3):185-96.

Psarras S, Mavroidis M, Sanoudou D, Davos CH, Xanthou G, Varela AE, Panoutsakopoulou V, Capetanaki Y. Regulation of adverse remodelling by osteopontin in a genetic heart failure model. Eur Heart J. 2012 Aug;33(15):1954-63.

Qian J, Vafiadaki E, Florea S, Singh V, Song W, Lam CK, Yuan Q, Pritchard TJ, Rodriguez P, Wang Y, Haghighi K, Sanoudou D, Cai W, Wang HS, Fan GC, Kranias EG: Small Heat Shock Protein 20 interacts with protein phosphatise-1 and enhances sarcoplasmic reticulum calcium cycling. Circ Res. 108(12):1429-1438, 2011.

Han P, Cai W, Wang Y, Lam CK, Arvanitis DA, Singh V, Chen S, Zhang H, Zhang R, Cheng H, Kranias EG: Catecholaminergic Induced Arrhythmias in Failing Cardiomyocytes Associated with Human HRCS96A Variant Overexpression. Am. J. Phys. Heart Circ. Phys. 301(4):H1588-1595, 2011.

Altschafl BA, Arvanitis DA, Fuentes O, Yuan Q, Kranias EG, Valdivia HH: Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes. J Physiol. 589(PT 24): 6063-6080, 2011.

Sakellariou A, Sanoudou D, Spyrou G. Investigating the minimum required number of genes for the classification of neuromuscular disease microarray data. IEEE Trans Inf Technol Biomed. 2011 May;15(3):349-55.

Wang HS, Arvanitis DA, Dong M, Niklewski PJ, Zhao W, Lam CK, Kranias EG, Sanoudou D. SERCA2a Superinhibition by Human Phospholamban Triggers Electrical and Structural Remodelling in Mouse Hearts. Physiol Genomics. 2011. Apr 12;43(7):357-64.

Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG. Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.  J Mol Cell Cardiol. 2011 Jan;50(1):43-9. Epub 2010 Aug 31.

Luo J, Schumacher M, Scherer A, Sanoudou D, Megherbi D, Davison T, Shi T, Tong W, Shi L, Hong H, Zhao C, Elloumi F, Shi W, Thomas R, Lin S, Tillinghast G, Liu G, Zhou Y, Herman D, Li Y, Deng Y, Fang H, Bushel P, Woods M, Zhang J. A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data.  Pharmacogenomics J. 2010 Aug;10(4):278-91.

Vafiadaki E, Arvanitis DA, Kranias EG, Sanoudou D. Pharmacogenetically tailored treatments for heart disease. Curr Pharm Des. 2010;16(20):2194-213.

Sanoudou D. Pharmacogenomics: achievements, challenges and prospects, for patients, pharmaceutical industries and healthcare systems. Curr Pharm Des. 2010;16(20):2182-3.

Papalouka V, Arvanitis DA, Vafiadaki E, Papadodima SA, Spiliopoulou CA, Kremastinos D, Kranias EG, Sanoudou D. Muscle Lim Protein interacts with Cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle. Mol Cell Biol. 2009 Nov;29(22):6046-58. Epub 2009 Sep 14

Al-Qusairi L, Weiss N, Toussaint A, Berbey C, Messaddeq N, Kretz C, Sanoudou D, Beggs AH, Allard B, Mandel JL, Laporte J, Jacquemond V, Buj-Bello A. T-tubule disorganization and defective excitation-contraction coupling in muscle fibers lacking myotubularin lipid phosphatase. Proc Natl Acad Sci U S A. Nov 3;106(44):18763-8. Epub 2009 Oct 21

Sanoudou D, Duka A, Drosatos K, Hayes KC, Zannis VI. Role of Esrrg in the fibrate mediated regulation of genes of lipid metabolism in human apoA-I transgenic mice. Pharmacogenomics J. 2010 Jun;10(3):165-79. Epub 2009 Dec 1.

Vafiadaki E, Arvanitis DA, Pagakis SN, Papalouka V, Sanoudou D, Kontrogianni-Konstantopoulos A, and Kranias EG. The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival. Mol Biol Cell. 2009 Jan;20(1):306-18

Vafiadaki E, Papalouka V, Arvanitis DA, Kranias EG, and Sanoudou D. The role of SERCA2a/PLN complex, Ca2+ homeostasis and anti-apoptotic proteins in determining cell fate. Pflugers Arch. 2009 Jan;457(3):687-700.

Arvanitis DA, Sanoudou D, Kolokathis F, Vafiadaki E, Papalouka V, Kontrogianni-Konstantopoulos A, Theodorakis GA, Paraskevaidis IA, Adamopoulos S, Dorn II GW, Kremastinos DTh, Kranias EG. The Ser96Ala Variant in Histidine-Rich Calcium Binding Protein Is Associated With Life-Threatening Ventricular Arrhythmias in Nonischemic Dilated Cardiomyopathy. Eur Heart J. 2008 Oct;29(20):2514-25.

Garbis SD, Tyritzis SI, Roumeliotis T, Zerefos P, Giannopoulou EG, Vlahou A, Kossida S, Diaz J, Vourekas S, Tamvakopoulos C, Pavlakis K, Sanoudou D, Constantinides CA. Search for potential markers for prostate cancer diagnosis, prognosis and treatment in clinical tissue specimens using amine-specific isobaric tagging (iTRAQ) with two-dimensional liquid chromatography and tandem mass spectrometry. J Proteome Res. 2008 Aug;7(8):3146-58

Vafiadaki E, Sanoudou D, Arvanitis DA, Catino DH, Kranias EG, Kontrogianni-Konstantopoulos, A. Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function. J Mol Biol. 2007 Mar 16;367(1):65-79

Arvanitis DA, Vafiadaki E, Mitton BA, Gregory KN, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG. The Histidine-Rich Calcium Binding Protein Interacts With Sarcoplasmic Reticulum Ca-ATPase. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1581-9

Sanoudou D, Vafiadaki E, Arvanitis DA, Kranias EG, Kontrogianni-Konstantopoulos A. Array lessons from the heart: focus on the genome and transcriptome of cardiomyopathies. Physiol Genomics. 2005 Apr 14;21(2):131-43.

Sanoudou D, Corbett MA, Han M, Ghoddusi M, Nguyen MA, Vlahovich N, Hardeman EC, Beggs AH. Skeletal muscle repair in a mouse model of nemaline myopathy. Hum Mol Genet. 2006 Sep 1;15(17):2603-12.

Gazda HT, Kho AT, Sanoudou D, Zaucha JM, Kohane IS, Sieff CA, Beggs AH. Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia. Stem Cells. 2006 Sep;24(9):2034-44

Barnes CM, Huang S, Kaipainen A, Sanoudou D, Chen EJ, Eichler GS, Guo Y, Yu Y, Ingber DE, Mulliken JB, Beggs AH, Folkman J, Fishman SJ. Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19097-102.

Haslett JN, Kang PB, Han M, Kho AT, Sanoudou D, Volinski JM, Beggs AH, Kohane IS, Kunkel LM. The influence of muscle type and dystrophin deficiency on murine expression profiles. Mamm Genome. 2005 Oct;16(10):739-48

Kang PB, Kho AT, Sanoudou D, Haslett JN, Dow CP, Han M, Blasko JM, Lidov HG, Beggs AH, Kunkel LM. Variations in gene expression among different types of human skeletal muscle. Muscle Nerve. 2005 Oct;32(4):483-91

Greenberg SA, Pinkus JL, Pinkus GS, Burleson T, Sanoudou D, Tawil R, Barohn RJ, Saperstein DS, Briemberg HR, Ericsson M, Park P, Amato AA. Interferon-alpha/beta-mediated innate immune mechanisms in dermatomyositis. Ann Neurol. 2005 May;57(5):664-78.

Liadaki K, Kho AT, Sanoudou D, Schienda J, Flint A, Beggs AH, Kohane IS, Kunkel LM. Side population cells isolated from different tissues share transcriptome signatures and express tissue-specific markers. Exp Cell Res. 2005 Feb 15;303(2):360-74.

Nicolaou P, Rodriguez P, Ren X, Zhou X, Qian J, Sadayappan S, Mitton B, Pathak A, Robbins J, Hajjar RJ, Jones K, Kranias EG. Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circ Res. 2009 Apr 24;104(8):1012-20.

Yuan Q, Han P, Dong M, Ren X, Zhou X, Chen S, Jones WK, Chu G, Wang HS, Kranias EG. Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1484-90.

Waggoner JR, Ginsburg KS, Mitton B, Haghighi K, Robbins J, Bers DM, Kranias EG. Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H698-703.

Diwan A, Matkovich SJ, Yuan Q, Zhao W, Yatani A, Brown JH, Molkentin JD, Kranias EG, Dorn GW 2nd. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. J Clin Invest. 2009 Jan;119(1):203-12.

Chen G, Zhou X, Pathak A, Dorn GW, Kranias EG. The human G147D-protein phosphatase 1 inhibitor-1 polymorphism is not associated with altered clinical characteristics in heart failure. Cardiology. 2009;112(3):224-31.

Zhao W, Fan GC, Zhang ZG, Bandyopadhyay A, Zhou X, Kranias EG. Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis. Basic Res Cardiol. 2009 Jul;104(4):377-89

Fan GC, Ren X, Qian J, Yuan Q, Nicolaou P, Wang Y, Jones WK, Chu G, Kranias EG. Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation. 2005 Apr 12;111(14):1792-9.

Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bodi I, Weiser D, Hahn H, Carr AN, Syed F, Mavila N, Jha L, Qian J, Marreez Y, Chen G, McGraw DW, Heist EK, Guerrero JL, DePaoli-Roach AA, Hajjar RJ, Kranias EG. Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circ Res. 2005 Apr 15;96(7):756-66.

Chu G, Kerr JP, Mitton B, Egnaczyk GF, Vazquez JA, Shen M, Kilby GW, Stevenson TI, Maggio JE, Vockley J, Rapundalo ST, Kranias EG. Proteomic analysis of hyperdynamic mouse hearts with enhanced sarcoplasmic reticulum calcium cycling. FASEB J. 2004 Nov;18(14):1725-7.

Haghighi K, Gregory KN, Kranias EG. Sarcoplasmic reticulum Ca-ATPase-phospholamban interactions and dilated cardiomyopathy. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1214-22. Review.

Zhao W, Uehara Y, Chu G, Song Q, Qian J, Young K, Kranias EG. Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility. J Mol Cell Cardiol. 2004 Aug;37(2):607-12.

Fan GC, Gregory KN, Zhao W, Park WJ, Kranias EG. Related Articles, Links Regulation of myocardial function by histidine-rich, calcium-binding protein. Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1705-11.

Fan GC, Chu G, Mitton B, Song Q, Yuan Q, Kranias EG. Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis. Circ Res. 2004 Jun 11;94(11):1474-82.

Song Q, Young KB, Chu G, Gulick J, Gerst M, Grupp IL, Robbins J, Kranias EG. Overexpression of phospholamban in slow-twitch skeletal muscle is associated with depressed contractile function and muscle remodeling. FASEB J. 2004 Jun;18(9):974-6.

Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewett TE, Bibb JA, Westfall MV, Kranias EG, Molkentin JD. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med. 2004 Mar;10(3):248-54.

Gregory KN, Hahn H, Haghighi K, Marreez Y, Odley A, Dorn GW 2nd, Kranias EG. Increased particulate partitioning of PKC epsilon reverses susceptibility of phospholamban knockout hearts to ischemic injury. J Mol Cell Cardiol. 2004 Feb;36(2):313-8.

Chu G, Egnaczyk GF, Zhao W, Jo SH, Fan GC, Maggio JE, Xiao RP, Kranias EG. Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20. Circ Res. 2004 Feb 6;94(2):184-93.

MacLennan DH, Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol. 2003 Jul;4(7):566-77. Review.

Schmidt AG, Haghighi K, Frank B, Pater L, Dorn GW, Walsh RA, Kranias EG. Polymorphic SERCA2a variants do not account for inter-individual differences in phospholamban-SERCA2a interactions in human heart failure. J Mol Cell Cardiol. 2003 Jul;35(7):867-70. No abstract available.

Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, Fan GC, Tsiapras D, Hahn HS, Adamopoulos S, Liggett SB, Dorn GW 2nd, MacLennan DH, Kremastinos DT, Kranias EG. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest. 2003 Mar;111(6):869-76.

Song Q, Schmidt AG, Hahn HS, Carr AN, Frank B, Pater L, Gerst M, Young K, Hoit BD, McConnell BK, Haghighi K, Seidman CE, Seidman JG, Dorn GW 2nd, Kranias EG. Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. J Clin Invest. 2003 Mar;111(6):859-67.

Brittsan AG, Ginsburg KS, Chu G, Yatani A, Wolska BM, Schmidt AG, Asahi M, MacLennan DH, Bers DM, Kranias EG. Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport. Circ Res. 2003 Apr 18;92(7):769-76.

Arvanitis DA, Flouris GA, Spandidos DA. Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis. J Cell Mol Med. 2005 Jan-Mar;9(1):153-9.

Daly NL, Arvanitis DA, Fairley JA, Gomez-Roman N, Morton JP, Graham SV, Spandidos DA, White RJ. Deregulation of RNA polymerase III transcription in cervical epithelium in response to high-risk human papillomavirus. Oncogene. 2005 Jan 27;24(5):880-8.

Arvanitis DA, Lianos E, Soulitzis N, Delakas D, Spandidos DA. Deregulation of p73 isoform equilibrium in benign prostate hyperplasia and prostate cancer. Oncol Rep. 2004 Nov;12(5):1131-7.

Detorakis ET, Zafiropoulos A, Arvanitis DA, Spandidos DA. Detection of point mutations at codon 12 of KI-ras in ophthalmic pterygia. Eye. 2005 Feb;19(2):210-4.