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Welcome to Eleni Katsantoni Lab of BRFAA

Katsantoni Group focuses on the understanding of mechanisms of transcriptional regulation in normal and pathologic hematopoiesis. The role of signal transducers and activators of transcription (STATs) is studied (Figure). JAK-STAT constitute one characteristic example of deregulated signaling pathway involved in carcinogenesis and constitutive activation of STATs is a hallmark for both hematopoietic and solid malignancies. STATs possess critical roles in multiple cellular functions. The Group is mainly focusing on understanding the role of STAT3 and STAT5, and addresses investigations on:

• The mechanisms of gene transcription controlled by the STATs and by the interactions of STATs with other factors in normal and pathologic hematopoietic cells. Target gene networks functions of STATs and of the interacting partners are investigated in a temporal and spatial manner.
• The role of STATs in leukemic transformation.
• The role of STATs and other transcription factors in ineffective erythropoiesis.

The Group’s future goal is to translate the basic research findings in novel therapeutic targets and biomarkers for therapeutic management / stratification of hematologic and solid malignancies.