Publications

Dimitra Kerdidani, Nikos E. Papaioannou, Evangelia Nakou and Themis Alissafi. Rebooting Regulatory T Cell and Dendritic Cell Function in Immune-Mediated Inflammatory Diseases: Biomarker and Therapy Discovery under a Multi-Omics Lens. Biomedicines 2022, 10(9), 2140; https://doi.org/10.3390/biomedicines10092140

Aikaterini Hatziioannou, Athina Boumpas, Miranta Papadopoulou, Iosif Papafragkos, Athina Varveri, Themis Alissafi and Panayotis Verginis. Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle.
Front Immunol 2021 Sep 3;12:731947. doi: 10.3389/fimmu.2021.731947.

Ioannis Kokkinopoulos, Aggelos Banos, Maria Grigoriou, Anastasia Filia, Theodora Manolakou, Themis Alissafi, Nikolaos Malissovas, Ioannis Mitroulis, Panayotis Verginis, Dimitrios T Boumpas. Patrolling human SLE haematopoietic progenitors demonstrate enhanced extramedullary colonisation; implications for peripheral tissue injury. Sci Rep 2021 Aug 3;11(1):15759. doi: 10.1038/s41598-021-95224-y.

Maria Grigoriou, Aggelos Banos, Aikaterini Hatzioannou, Andreas Kloetgen, Panagiotis Kouzis, Despoina Aggouridaki, Roubini Zakopoulou, Giorgos Bamias, Eva Kassi, Dimitrios Mavroudis, Aristotelis Bamias, Dimitrios T Boumpas, Aristotelis Tsirigos, Helen Gogas, Themis Alissafi, Panayotis Verginis. Regulatory T-cell Transcriptomic Reprogramming Characterizes Adverse Events by Checkpoint Inhibitors in Solid Tumors.
Cancer Immunol Res 2021 Jul;9(7):726-734. doi: 10.1158/2326-6066.CIR-20-0969.

Antonis Stylianos Papaioannou, Athina Boumpas, Miranta Papadopoulou, Aikaterini Hatzioannou, Themis Alissafi, Panayotis Verginis. Measuring Suppressive Activity and Autophagy in Myeloid-Derived Suppressor Cells
Methods Mol Biol 2021;2236:85-98. doi: 10.1007/978-1-0716-1060-2_9.

Alissafi T, Kalafati L, Lazari M, Filia A, Kloukina I, Manifava M, Lim JH, Alexaki VI, Ktistakis NT, Doskas T, Garinis GA, Chavakis T, Boumpas DT, Verginis P. Mitochodrial Oxidative Damage Underlies Regulatory T cells Defects in Autoimmunity Cell Metab. 2020 Oct 6;32(4):591-604.e7. doi: 10.1016/j.cmet.2020.07.001.

T Alissafi, A Hatziioannou, A.I. Legaki, A Varveri, Panayotis Verginis. Balancing cancer immunotherapy and immune related adverse events:The emerging role of regulatory T cells. J Autoimmun 2019 Nov;104:102310. doi: 10.1016/j.jaut.2019.102310.

Alissafi T, Hatzioannou A, Mintzas K, Barouni RM, Banos A, Sormendi S, Polyzos A, Xilouri M, Wielockx B, Gogas H, Verginis P. Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells.  J Clin Invest. 2018 Aug 31; 128(9):3840-3852. doi: 10.1172/JCI120888.

Hatziioannou A, Alissafi T, Verginis P. Myeloid-derived suppressor cells and T regulatory in tumors:unraveling the dark side of the force. J Leukoc Biol. 2017 Aug;102(2):407-421. doi: 10.1189/jlb.5VMR1116-493R.

Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P. Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. J Clin Invest. 2017 Jun 30; 127(7):2789-2804. doi: 10.1172/JCI92079.

Themis Alissafi, Aikaterini Hatzioannou, Marianna Ioannou, Tim Sparwasser, Joachim R Grun, Andreas Grutzkau, Panayotis Verginis. De novo-induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory dendritic cells in draining lymph nodes. J Immunol 2015 Jun 15;194(12):5812-24. doi: 10.4049/jimmunol.1500111.