Publications

Capetanaki, Y., and Alonso, A. (1980) Comparison of polysomal and nuclear poly (A)-containing RNA populations from normal rat liver and Novilkoff hepatoma cells. Nucl. Acid Res. 8(4), 3193-3214.

Capetanaki, Y., and Alonso, A. (1980) Gene expression in normal rat liver and Novikoff hepatoma. European J. Cell Biol. 22(1), 57.

Capetanaki, Y. (1980) Gene expression in Novikoff hepatoma cells in comparison to normal rat liver. Control of albumin gene expression in Novikoff hepatoma. Ph.D. Thesis

Capetanaki, Y., Flytzanis, C., and Alonso, A. (1982) Repression of the albumin gene in Novikoff hepatoma cells. Mol. Cell Biol. 2, 258-266.

Capetanaki, Y., Ngai, J., Flytzanis, C.N., and Lazarides, E. (1983) Tissue-specific expression of two mRNA species transcribed from a single vimentin gene. Cell 35, 411-420.

Ngai, J., Capetanaki, Y., and Lazarides, E. (1984) Differentiation of murine erythroleukemia cells results in the rapid repression of vimentin gene expression. J. Cell Biol. 99, 306-314.

Capetanaki, Y., Ngai, J., and Lazarides, E. (1984) Characterization and regulation in the expression of a single gene coding for the intermediate filament protein desmin. Proc. Natl. Acad. Sci. USA 81, 6909-6913.8

Capetanaki, Y., Ngai, J., and Lazarides, E. (1984) Regulation of the expression of the genes coding for the intermediate filament subunits vimentin, desmin and glial fibrillary acidic protein. In: Molecular Biology of Cytoskeleton (ed. G.G. Borisy et al.), Cold Spring Harbor Symposia 415-434.

Ngai, J., Capetanaki, Y., and Lazarides, E. (1986) Expression of the intermediate filament proteins vimentin and desmin. In: Intermediate filaments, Annals of the New York Academy of Science 455, 144-157.

Lazarides, E. and Capetanaki, Y. (1986) The striated muscle cytoskeleton: Expression and assembly in development. ICN-UCLA Symposia, in Molecular Biology of Muscle Development, 749-772.

Olson, E.N. and Capetanaki, Y. (1989) Developmental regulation of intermediate filament and actin mRNAs during myogenesis is disrupted by oncogenic H-ras genes. Oncogene 4, 907-913.

Capetanaki, Y., Starnes, S., and Smith, S. (1989) Expression of the chicken vimentin gene in transgenic mice: efficient assembly of the avian protein into the cytoskeleton. Proc. Natl. Acad. Sci., USA 86, 4882-4886.

Capetanaki, Y. Smith, S., and Heath, J. (1989) Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation. J. Cell Biol. 109, 1653-1664.

Capetanaki, Y., Kuisk, I., Rothblum, K., and Starnes, S. (1990) Mouse vimentin: strucural relationship to fos, jun, CREB and TPR. Oncogene 5, 645-655.

Li, H., Kuisk, I., and Capetanaki, Y. (1990) Desmin and muscle differentiation: Relationship to the myogenic transcription regulators myoD and myogenin. J. Cell Biol. 111, 44a.

Carpenter, D., Capetanaki, Y., Khan, S. and lp.N. (1992) Phosphorylation-induced disassembly of intermediate filaments is not required for progression through mitosis. Mol. Biol.of Cell 3,350a

Li, H., and Capetanaki, Y., (1993) Regulation of the mouse desmin gene: Transactivation by myoD, myogenin, MRF4 and myf5. Nucl. Acid. Res. 21, 335-343.

Hornbeck, P.V., Garrels, J.I., Capetanaki, Y., and Heimer, S., (1993) Vimentin is differentially regulated by recombinant IL-2 and IL-4 in murine T cells. J. Immunol. 151, 4013-4021.

Li, H., Choudhary, S., Milner, D.Munir, I., M., Kuisk, I., and Capetanaki, Y., (1994) Inhibition of desmin expression blocks myogenic differentiation and interferes with the myogenic regulators myoD and myogenin. J. Cell Biol. 124, 827-841.

Li, H., and Capetanaki, Y.,(1994) An E-box in the desmin promoter cooperates with the E box and MEF-2 sites of a distal enhancer to direct muscle-specific transcription. EMBO J.13, 3580-3589.

Gillard, B.K., Thurmon, L.T., Capetanaki, Y. Yu, R.K. and Marcus, D.M., (1994) Biosynthesis of Glycosphingolipids is reduced in the absence of vimentin intermediate filament network. J Cell Science 107, 3545-3555.

Weitzer, G., Kim, J.-U. Bradley, A. and Capetanaki, Y.(1995) Cytoskeletal control of myogenesis: a desmin null mutation blocks the myogenic pathway during embryonic stem cell differentiation ..Dev. Biol.172, 422-439.

Kuisk , I., Tran, D. and Capetanaki, Y.(1996) A single MEF-2 site governs desmin transcription both in heart and skeletal muscle during mouse embryogenesis. Dev. Biol. 174, 1-13.

Milner, D., Weitzer, G., Tran, D., Bradley, A. and Capetanaki, Y. (1996) Disruption of muscle architecture and myocardial degeneration in mice lacking desmin. J. Cell Biol. 134, 1255-1270.

Capetanaki, Y., Milner, D. and Weitzer, G. (1997) Desmin in muscle formation and maintenance: Knock outs and consequences. Cell Structure & Function 22, 103-116.

Capetanaki, Y. and Milner, D. (1998) Desmin cytoskeleton in muscle integrity and function. In Intermediate Filaments.(ed. H. Hermann and Harris, Plenum Press, N.Y.) Subcellular Biochemistry, Chapter 16, vol 31, 463-495.

Weitzer, G., Weisleder, N., Li, H., Milner, D.J., Goerzer, I., Ellersdorter, G., Enzinger, S., Bader, A., Habegger, K., Hammer, E. and Capetanaki, Y(1999). Complete nucleotide sequense of the mouse desmin gene. Genbank accession #Z18892/#AF139662.

Milner, D. J., Taffet, J.E., Wang, X., Phan, T., Hartley, C., Gerdes, M. and Capetanaki, Y. (1999). The absence of desminl Leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function. J. Mol. & Cell Cardiology 31:2063-2076

Milner, D. J., Mavroidis, M., Weisleder, N. and Capetanaki, Y. (2000). Desmin cytoskeleton linked to muscle mitochondrial distribution and respiratory function . J. Cell Biol. 150: 1283-1297.

Capetanaki, Y. (2000). Desmin cytoskeleton in healthy and failing heart. In Cardiomyocyte Cytoskeleton and Associated proteins in Health and disease. Heart Failure. Reviews. Kluwer Academic Publishers. Netherlands, 5: 203-220.

Sam, M., Shah, S., Friden, J., Milner, D., Capetanaki, Y. and Lieber, R.L. (2000) Desmin knockout muscles generate lower stress but are less vulnerable to eccentric injury compared to wild type muscles Am. J. Physiol. 279:1116-1122.

Schweitzer, S.C., Klymkowsky, M.W., Bellin, R.M., Robson, R.M., Capetanaki, Y. and Evans, R.M. (2001). Paranemin and the organization of desmin filament network J. Cell Science 114:1079-89.

Boriek, A.M. , Capetanaki, Y., Hwang, W. Officer, T. Badshah, M., Rodarte, J. and Tidball, J. G. (2001). Desmin integrates the three-dimentional mechanical properties of muscles. Am. J. Physiol.Cell Physiol. 280:46-52

Shah, S.B., Peters, D., Jordan, K.A., Milner, D., Friden, J., Capetanaki, Y. and Lieber, R.L. (2001). Sarcomere number regulation maintained after immobilization in desmin null mouse skeletal muscle. J. Exp. Biol. 204:1703-1710.

Bader, A., Gruss, A., Hollrigl, A., Dubai, H.A., Capetanaki, Y. and Weitzer, G. (2001). Paracrine promotion of cardiomyogenesis in embryoid bodies by LIF modulated endoderm. Differentiation. 68:31-43.

Hollrigl, A., Ellersdorter, G., Hergovich, A., Goerzer, I., Bader, A., Habegger, K., Hammer, E., Enzinger, S., Capetanaki, Y. and Weitzer, G. High-throughput site-directed mutagenesis in ES cells. Bioch. Bioph. Res. Com. 289: 329-336..

Shah SB, Su FC, Jordan K, Milner DJ, Friden J, Capetanaki Y, Lieber RL. (2002). Evidence for increased myofibrillar mobility in desmin-null mouse skeletal muscle. J Exp Biol. 2002 205:321-325.

Mavroidis, M. and Capetanaki, Y. (2002) Extensive induction of important mediators of fibrosis and dystrophic calcification in desmin-deficient cardiomyopathy . Am.J.Pathol 160:943-952

O’Neill, A., Williams M.W., Resneck, W. G., Milner, DJ., Capetanaki, Y. and Bloch,R.J. (2002). Sarcolemmal organization in skeletal muscle lacking desmin:: Evidence for a second class of intermediate filaments. Mol. Biol Cell 13:2347-2359.

Bloch RJ, Capetanaki Y, O'Neill A, Reed P, Williams MW, Resneck WG, Porter NC, Ursitti JA. (2002). Costameres: Repeating Structures at the Sarcolemma of Skeletal Muscle. Clin. Orthop. 403:203-210

Hollrigl A, Puz S, Al-Dubai H, Kim JU, Capetanaki Y, Weitzer G. (2002). Amino-terminally truncated desmin rescues fusion of des(-/-) myoblasts but negatively affects cardiomyogenesis and smooth muscle development. FEBS Lett. 523:229-233

Capetanaki, Y.(2002) Desmin cytoskeleton a potential regulator of muscle mitochondrial behavior and function. Trends in Cardiovasc. Medicine 12:339-348.

Chen F, Chang R, Trivedi M, Capetanaki Y, Cryns VL. (2003) Caspase proteolysis of desmin produces a dominant negative inhibitor of intermediate filaments and promotes apoptosis. J Biol Chem. 278:6848-6853.

Houbold, K.W., Allen, D.L., Capetanaki,Y. and Leinwand, L.A. (2003). Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance. J. Appl. Physiol. 95: 1617-1622.

Camargo, F.D., Green, R., Capetanaki, Y.,Jackson, K.A. and Goodell, M. (2003). Single hematopoietic stem cells generate skeletal muscle via myeloid intermediates. Nature Medicine 9:1520-1527.

Weisleder, N, Taffet, G. and Capetanaki, Y. (2004) Over-expression of Bcl-2 corrects motichondrial defects and ameliorates inherited desmin null cardiomyopathy. Proc. Nat. Acad. Sci., USA. 101:769-774.

Weisleder, N., Soumaka, E., Abbasi, S., Heinrich Taegtmeyer, H., and Capetanaki, Y.(2004). Cardiomyocyte-specific desmin rescue of desmin null cardiomyopathy excludes vascular involvement. J. Mol. Cell. Cardiol. 36:121-128.

Shah, S.B., Davis, J., Weisleder, W., Kostavasili, I., McCulloch, A., D., Ralston‡, E., Capetanaki, Y and Lieber, R.L. (2004). Structural and functional roles of desmin in mouse skeletal muscle during passive deformation. Biophys. J. 86:2993-3008.

Fountoulakis, M., Soumaka, E., Rapti, K. Mavroidis, M., Tsangaris, G., Weisleder, W., and Capetanaki, Y. (2005). Alterations in the heart mitochondrial proteome in a desmin null heart failure model J.Mol. Cell. Cardiol. 38:461-474.

Shardonofsky, F.R., Capetanaki, Y., and Boriek, A.M. (2006). Desmin modulates lung elastic recoil and airway responsiveness. Am. J. Physiol. Lung Phys. 290:890-896

Ralston, E. Lu, Z., Biscocho, N., Soumaka, E. Mavroidis, M., Prats, C., Lomo, T., Capetanaki, Y. and Ploug, T. (2006) . Blood vessels and desmin control the positioning of nuclei in skeletal muscle fibres. J. Cell Physiol. 209: 874-882

Capetanaki, Y, Bloch,RJ., Kouloumenta, A., Mavroidis, M.,Psarras, S. (2007). Muscle intermediate filaments and their links to membranes and membranous organelles. Exp. Cell Res. 313: 2063-2076.

Kouloumenta, A., Mavroidis, M and Capetanaki, Y. (2007). Proper perinuclear localization of the TRIM-like protein myospryn requires its binding partener desmin. J. Biol. Chem. 282:35211-35221.

Panagopoulou, P. , Davos, C., Milner, D., Varela, E., J., Mann, D. and Capetanaki, Y. (2008). Desmin mediates TNF-a induced aggregate formation and intercalated disk reorganization in heart failure J. Cell Biol. 181: 761-775.

Mavroidis, M, Panagopoulou, P., Kostavasili, I., Weisleder, N. and Capetanaki, Y. (2008). A missence mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization. FASEB J. 22: 3318-3327.

Kypreou KP, Kavvadas P, Karamessinis P, Peroulis M, Alberti A, Sideras P, Psarras S, Capetanaki Y, Politis PK, Charonis AS. (2008). Altered expression of calreticulin during the development of fibrosis. Proteomics 8:2407-2419.

Georgiadou P., Iliodromitis E.K., Varounis C., Mavroidis M., Kolokathis, F., Andreadou I., Osarras, S., Capetanaki, Y., Boudoulas, H., Kremastinos, D.T. (2008). Relationship between plasma osteopontin and oxidative stress in patients with coronary artery disease. Expert Opin Ther Targets 12:917-920.

Georgiadou P., Iliodromitis EK., Kolokathis F., Mavroidis M., Andreadou I., Demopoulou, M., Varounis Ch., Capetanaki, Y., Boudoulas H., Kremastinos DT (2008). Plasma levels of osteopontin before and 24 h after percutaneous coronary intervention. Expert Opin Ther Targets 12:1477-1480 (2.45)

Georgiadou P, Iliodromitis EK, Kolokathis F, Varounis C, Gizas V, Mavroidis M, Capetanaki Y, Boudoulas H, Kremastinos DT. Osteopontin as a novel prognostic marker in stable ischaemic heart disease: a 3-year follow-up study. Eur J Clin Invest. 2010 Feb 19. [Epub ahead of print]

Van Spaendonck-Zwarts, K.Y., van Hessem, L., Jongbloed, J.D.H., Hermien E.K. de Walle , H.E.K., Capetanaki , Y., Anneke J. van der Kooi, A.J., Irene M. van Langen, I.M., Maarten P. van den Berg, M.P., and van Tintelen, J.P. (2010). Desmin related myopathy: a review and meta-analysis. Clinical Genetics(do:10.1111/j.1399-0004.2010.01512.x)

Psarras, S., Mavroidis, M., Sanoudou, D., Davos, C., Xanthou, G., Varela, E., Panoutsakopoulou, V, and Capetanaki,Y. (2012).  Regulation of Adverse Remodeling by Osteopontin in a Genetic Heart Failure Model . Eur. Heart J. 33:1954-1963. doi:10.1093/eurheart/erh119. Epub 2011 (Apr 26)