Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Georgia Georgia Sotiropoulou, PhD
University Faculty, Affiliated Investigator

Telephone : +30 210 6597 498
Fax : +30 210 6597 545
e-mail : gdsotiro@bioacademy.gr


Center :

Basic Research

Lab Site :

Vekrellis Lab


Selected Publications

Furio L, Pampalakis G, Michael IP, Nagy A, Sotiropoul ou G*, Hovnanian A. * (2015) Elimination of KLK5 reverses the hallmarks of Netherton syndrome. PLoS Genetics 2015 Sep 21;11(9):e1005389.

Ximerakis M, Pampalakis G, Roumeliotis TI, Sykioti V-S, Garbis SD, Stefanis L, Sotiropoulou G, Vekrellis  K. (2014) Resistance of naturally secreted alpha-synuclein  to proteolysis. FASEB J 28: 3146-3158. 

Pampalakis G, Obasuyi O, Papadodima O, Chatziioannou A, Zoumpourlis V, Sotiropoulou G. (2014) The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. Oncotarget 5: 2390-2403.

Sotiropoulou G, Pampalakis G. (2012) Targeting the kallikrein-related peptidases for drug development. Trends Pharmacol Sci 33: 623-634.

Pampalakis G, Prosnikli E, Agalioti T, Vlahou A, Zoumpourlis V, Sotiropoulou G. (2009) A tumor protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition. Cancer Res 69: 3779-3787.

Pampalakis G, Sotiropoulou G. (2007) Tissue kallikrein proteolytic cascade pathways in normal physiology and cancer. BΒΑ Rev Cancer 1776: 22-31. 

Borgoňo C, Michael IP, Komatsu N, Jayakumar A, Kapadia R, Clayman GL, Sotiropoulou G, Blaber M, Diamandis EP. (2007) A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation: Regulation by lympho-epithelial Kazal-type inhibitor and digestion of desmoglein 1. J Biol Chem 282: 3640-3652.

Michael IP, Pampalakis G, Mikolajczyk SD, Malm J, Sotiropoulou G, Diamandis EP. (2006) Human tissue kallikrein 5 (hK5) is a member of a proteolytic cascade involved in seminal clot liquefaction and potentially in prostate cancer progression. J Biol Chem 281: 12743-12750.

Bayés A, Tsetsenis T, Ventura S, Avilés FX, Vendrell J, Sotiropoulou G. (2004) Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation inactivation. Biol Chem 385: 517-524. 

Sotiropoulou G, Anisowicz A, Sager R. (1997) Identification, cloning and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer. J Biol Chem 272: 903-910.

Anisowicz A, Sotiropoulou G, Stenman G, Mok SC, Sager R. (1996) A novel protease homolog differentially expressed in breast and ovarian cancer. Mol Med 2: 624-636.

Sager R, Anisowicz A, Neveu M, Liang P, Sotiropoulou G. (1993) Identification by differential display of alpha 6 integrin as a candidate tumor suppressor gene. FASEB J 7: 964-970.

PubMed:

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