Publications

Jabado O, Wang Q, Rideout HJ, Yeasmin M, Guo K-X, Vekrellis K, Papantonis S, Angelastro JM, Troy CM, Stefanis L  (2004) “RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons” Cell Death Differ 11(6):618-30

Vekrellis K, Rideout HJ, Stefanis L (2004) “Neurobiology of a-synuclein” Mol Neurobiol 30(1):1-22

Lang-Rollin I, Vekrellis K, Wang Q, Rideout HJ, Stefanis L (2004) “Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway” J Neurochem 90(6):1511-1520

Lang-Rollin I, Maniati M, Jabado O, Vekrellis K, Papantonis S, Rideout HJ, Stefanis L (2005) “Apoptosis and the conformational change of Bax induced by proteasomal inhibition of PC12 cells are inhibited by bcl-xL and bcl-2”. Apoptosis 10(4):809-20

Rubinsztein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH, Ravikumar B, Stefanis L, Tolkovsky A. (2005) “Autophagy and its possible roles in nervous system diseases, damage and repair” Autophagy 1(1):11-22.

Wang Q, Maniati M, Jabado O, Pavlaki M, Troy CM, Greene LA, Stefanis L (2006) "RAIDD is required for apoptosis of PC12 cells and sympathetic neurons induced by trophic factor withdrawal"  Cell Death Differ 13(1):75-83

Clough RL, Stefanis L (2007) “A novel pathway for transcriptional regulation of alpha-synuclein” FASEB J 21(2):596-607

Kyratzi E, Pavlaki M, Kontostavlaki D, Rideout HJ, Stefanis L (2007) “Differential effects of Parkin and its mutants on protein aggregation, the ubiquitin-proteasome system and neuronal cell death in human neuroblastoma cells” J Neurochem 102(4):1292-303

Lang-Rollin I, Dermentzaki G, Vekrellis K, Xilouri M, Rideout HJ, Stefanis L (2008) “A novel cell death pathway that is partially caspase-dependent, but morphologically non-apoptotic, elicited by proteasomal inhibition of rat sympathetic neurons” J Neurochem 105(3):653-65.

Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L (2008) “Wild type -synuclein is degraded by chaperone mediated autophagy and macroautophagy in neuronal cells” J Biol Chem 283(35):23542-56.

Kyratzi E, Pavlaki M, Stefanis L (2008) “The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells” Hum Mol Genetics 17(14):2160-71.

Xilouri M, Vogiatzi T, Vekrellis K, Stefanis L (2008) “Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesis” Autophagy 4(7): 917-919.

Emmanouilidou E, Stefanis L, Vekrellis K (2010) “Specific cell-derived soluble alpha-synuclein oligomers are degraded by the 26S proteasome and impair its function” Neurobiol Aging 31(6):953-68

Vekrellis K, Xilouri M, Emmanouilidou E, Stefanis L (2009) “Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death” J Neurochem. 109(5):1348-62.

Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L (2009) “Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy” PLoS ONE 4(5):e5515.

Clough RL, Dermentzaki G, Stefanis L (2009) “Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219” J Neurochem 110(5):1479-90.

Ho CC, Rideout HJ, Ribe E, Troy CM, Dauer WT (2009) «The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration». J Neurosci 29(4):1011-6.

Emmanouilidou E, Melachroinou K, Garbis S., Ntzouni M., Margaritis L., Stefanis L, Vekrellis K (2010) «Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival». J. Neurosci 30(20):6838-51

Sotiriou E, Vassilatis DK, Vila M, Stefanis L (2010) “Selective noradrenergic vulnerability in alpha-synuclein transgenic mice”.  Neurobiol Aging 31(12):2103-14

Xilouri M, Stefanis L (2010) «Autophagy in the central nervous system: implications for neurodegenerative disorders». CNS Neurol Disord Drug Targets. 9(6):701-19.

Clough RL, Dermentzaki G, Haritou M, Petsakou A, Stefanis L (2011). «Regulation of α-synuclein expression in cultured cortical neurons» J Neurochem. 117(2):275-85.

Xilouri M, Stefanis L (2011) «Autophagic pathways in Parkinson disease and related disorders» Expert Rev Mol Med. 13:e8.

Xiromerisiou G, Kyratzi E, Dardiotis E, Bozi M, Tsimourtou V, Stamboulis E, Ralli S, Vassilatis D, Gourbali V, Kountra PM, Fountas K, Papadimitriou A, Stefanis L,

Hadjigeorgiou GM (2011) “Lack of Association of the UCHL-1 gene with Parkinson's disease in a greek cohort: A haplotype-tagging approach”. Mov Disord. 26(10):1955-7

Moraitou M, Hadjigeorgiou G, Monopolis I, Dardiotis E, Bozi M, Vassilatis D, Vilageliu L, Grinberg D, Xiromerisiou G, Stefanis L, Michelakakis H (2011) «β-Glucocerebrosidase gene mutations in two cohorts of Greek patients with sporadic Parkinson's disease». Mol Genet Metab. 104(1-2):149-52

Droggiti A, Ho CC, Stefanis L, Dauer WT, Rideout HJ (2011) «Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death». J Neurochem. 119(3):630-43.

Vamvaca K, Lansbury PT, Stefanis L (2011) «N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast». J Neurochem. 119(2):389-97

Vekrellis K, Xilouri M, Emmanouilidou E, Rideout HJ, Stefanis L (2011) «Pathological roles of α-synuclein in neurological disorders». Lancet Neurol. 10(11):1015-25

Xilouri M, Kyratzi E, Pitychoutis PM, Papadopoulou-Daifoti Z, Perier C, Vila M, Maniati M, Ulusoy A, Kirik D, Park DS, Wada K, Stefanis L (2012) «Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system». Hum Mol Genet. 21(4):874-89.

Michelakakis H, Xiromerisiou G, Dardiotis E, Bozi M, Vassilatis D, Kountra PM, Patramani G, Moraitou M, Papadimitriou D, Stamboulis E, Stefanis L, Zintzaras E,

Hadjigeorgiou GM (2012)  «Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's disease».  Mov Disord. 27(3):400-5

Stefanis L (2012) «α-Synuclein in Parkinson's disease». Cold Spring Harb Perspect Med. 2(2):a009399

Vekrellis K, Stefanis L (2012) «Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies» Expert Opin Ther Targets.16(4):421-32

Argyriou A, Dermentzaki G, Papasilekas T, Moraitou M, Stamboulis E, Vekrellis K, Michelakakis H, Stefanis L (2012) «Increased dimerization of alpha-synuclein in erythrocytes in Gaucher disease and aging» Neurosci Lett. 528(2):205-9

Xilouri M, Brekk OR, Stefanis L (2013) «α-Synuclein and protein degradation systems: a reciprocal relationship» Mol Neurobiol. 47(2):537-51

Xilouri M, Brekk OR, Landeck N, Pitychoutis PM, Papasilekas T, Papadopoulou-Daifoti Z, Kirik D, Stefanis L (2013) Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration. Brain 136:2130-46

Melachroinou K, Xilouri M, Emmanouilidou E, Masgrau R, Papazafiri P, Stefanis L, Vekrellis K (2013) «Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity» Neurobiol Aging 34(12):2853-65

Dermentzaki G, Dimitriou E, Xilouri M, Michelakakis H, Stefanis L (2013) «Loss of β-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells» PLoS One. 8(4):e60674

Xilouri M, Brekk OR, Kirik D, Stefanis L (2013) «LAMP2A as a therapeutic target in Parkinson disease» Autophagy 9(12):2166-8

Dulovic M, Jovanovic M, Xilouri M, Stefanis L, Harhaji-Trajkovic L, Kravic-Stevovic T, Paunovic V, Ardah MT, El-Agnaf OM, Kostic V, Markovic I, Trajkovic V (2014) The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro. Neurobiol Dis. 63:1-11.

Bozi M, Papadimitriou D, Antonellou R, Moraitou M, Maniati M, Vassilatis DK, Papageorgiou SG, Leonardos A, Tagaris G, Malamis G, Theofilopoulos D, Kamakari S, Stamboulis E, Hadjigeorgiou GM, Athanassiadou A, Michelakakis H, Papadimitriou A, Gasser T, Stefanis L (2014) Genetic assessment of familial and early-onset Parkinson's disease in a Greek population. Eur J Neurol. [Epub ahead of print]