Current research in the lab focuses on macromolecules involved in renal fibrosis, their role in the process and the possibility to use them as markers of the fibrotic process. To that end, cell culture systems, animal models and biopsy material from patients suffering from renal diseases are used. We focus on calreticulin, transgelin and the family of 14-3-3 proteins. We are interested both in the molecular mechanisms of their up-regulation at early stages of fibrosis and in their use as early markers.