Biomedical Research Foundation Academy Of AthensAcademy Of Athens
Scientific Personnel

Dimitris Dimitris Beis, PhD
Investigator - Assistant Professor Level

Telephone : +30 210 6597 197
Fax : +30 210 6597 545
e-mail : dbeis@bioacademy.gr


Center :

Clinical, Experimental Surgery & Translational Research

Lab Site :

Beis Lab


Brief Bio

Dimitris Beis graduated from the Biotechnology Department of the Agricultural University of Athens and received his PhD from the Molecular Cell Biology Department of the University of Utrecht, the Netherlands in the lab of Prof. Ben Scheres. During his graduate studies, he elucidated the mechanisms by which the plant hormone auxin patterns the Arabidopsis root and identified the PLETHORA transcription factors downstream of auxin that are necessary for patterning of the Arabidopsis root stem cell niche.

Beis moved to Didier Stainier's laboratory in the University of California San Francisco to work on zebrafish cardiovascular development. He joined a group of post-docs from the Stainier and Baier labs in UCSF working on a large-scale forward genetic screen, looking for cardiovascular mutants. He identified more than a dozen, novel mutant lines that show defects in cardiac valve development.

Beis received a Long-term Fellowship in 2002 and a Career Development Award in 2006 from the Human Frontier Science Program Organization. He participates in the Managing Committee of EuFishBiomed: an initiative to promote zebrafish Biomedical Research, supported by an ESF COST action (BM0804).

He is in BRFAA since 2006 as an ENTER fellow funded by the Greek General Secretariat for Research and Technology and became Investigator C in the Developmental Biology lab in May 2008.

Selected Publications

Malissovas N, Griffin LB, Antonellis A and Beis D (2016) Dimerization is required for GARS-mediated neurotoxicity in dominant CMT disease. Human Molecular Genetics 25(8):1528-42.

Papakyriakou A, Kefalos P, Sarantis P, Tsiamantas C, Xanthopoulos KP, Vourloumis D, Beis D. (2014) A zebrafish in vivo phenotypic assay to identify 3-aminothiophene-2-carboxylic acid-based angiogenesis inhibitors. Assay Drug Dev Technol. (9-10):527-35. 

Kalogirou S, Malissovas N, Moro E, Argenton F, Stainier DY, Beis D. (2014) Intracardiac flow dynamics affect the morphogenesis and maturation of the atrioventricular valves. Cardiovasc Res. 104(1):49-60  

Beis D. and Stainier DYR. (2006) In vivo cell Biology: following the zebrafish trend. Trends in Cell Biology 16(2):105-12

Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY. (2008) Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. May 13;6(5):e109

Jin SW, Herzog W, Santoro MM, Mitchell TS, Frantsve J, Jungblut B, Beis D, Scott IC, D'Amico LA, Ober EA, Verkade H, Field HA, Chi NC, Wehman AM, Baier H, Stainier DY. (2007) A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Dev Biol. Jul 1;307(1):29-42.

Pyriochou A, Beis D, Koika V, Polytarchou C, Papadimitriou E, Zhou Z, Papapetropoulos A. (2006) Soluble guanylyl cyclase activation promotes angiogenesis. J Pharmacol Exp Ther. 319(2):663-71.

Jin SW, Beis D, Mitchell T, Chen JN and Stainier DYR. (2005) Cellular and Molecular Analysis of Vascular Tube and Lumen Formation in Zebrafish. Development 132(23):5199-209

Beis D, Bartman T, Jin SW, Scott I, D’Amico L, Ober E, Verkade H, Frantsve J, Field H, Wehman A, Baier H, Tallafuss A, Bally-Cuif L, Chen JN, Stainier DYR and Jungblut B*. (2005) Genetic and Cellular analyses of zebrafish atrio-ventricular cushion and valve development. Development 132(18):4193-204

Parker L.H, Schmidt M, Jin S.W, Gray A.M , Beis D, Pham T, Frantz G, Palmieri S, Hillan K, Stainier D.Y.R, de Sauvage F.J, and Ye W. (2004) The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature 428:754-8.

Field H, Dong P.D, Beis D, and Stainier D.Y.R. (2003)  Formation of the digestive system in zebrafish II. Pancreas morphogenesis  Developmental Biology 261:197–208

Aida M*, Beis D*, Heidstra R, Nussaume L, Noh Y.S, Amasino R, Sabatini S and Scheres B. (2004) The PLETHORA Genes Mediate Patterning of the Arabidopsis Root Stem Cell Niche. Cell 119:109-20.

PubMed:

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