“Alpha-synuclein and the lysosomes
in Parkinson’s Disease: A Complicated Relationship”
Scientific Meeting
June 12-13 2015

Dr. Leonidas Stefanis & Dr. Kostas Vekrellis are organizing Scientific Meeting under the framework of GSRT’s “ARISTEIA I & II” programs.  The Scientific Meeting is titled, “Alpha-synuclein and the lysosomes in Parkinson’s Disease: A Complicated Relationship” and will be held June 12-13, 2015 at the BRFAA amphitheater.

Alpha-synuclein (AS) is genetically and biochemically linked to Parkinson’s Disease PD. The total levels of the protein appear to be a critical factor since intracellular accumulation of AS can cause neuronal cell death. One of the major degradation pathways of AS is through the lysosome via autophagy. In addition, AS can be physiologically secreted and as such it can elicit paracrine actions that seem to aid the transmission of PD pathology. Our ARISTEIA meeting will address new insights as to how alterations of the lysosomal/autophagic pathway can modify the intracellular and extracellular levels of AS and whether this pathway can be a target for disease intervention.

Click here to download the program