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An extensive effort is made by
The Gene Ontology Consortium in order to gather all the
protein – function pairs in a standard format and produce a well
structured vocabulary that would present all the known
biological functions in a hierarchical, controlled structure.
Here, we present a tool which takes advantage of the Gene
Ontology (GO) to extract the proteins’ main attributes.
What is an Ontology?
An ontology is defined as a structured controlled vocabulary
that represents a domain and is used to reason about the objects
of that domain and the relationships between them.
The Gene Ontology is divided into three ontologies that were
found to yield information common to all living organisms.
The Ontology of
Cellular Component (CC)
describes the places in the cell where gene products would be
found
The Ontology of
Molecular Function (MF)
describes the biochemical activity of a gene product without
specifying the time or the space where this event occurred. It
is a usual feature for a molecular function term to be directly
characterized by its annotated gene product.
The Ontology of
Biological Process (BP)
consists of one or more ordered assemblies of functions. There
is a considerable relevance between molecular function and
biological process ontologies.
• Why
you want to choose TAGGO
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Potential
of discarding annotations that are supported by not so
reliable ECs
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Extremely
fast process
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All
the protein – GO term pairs considered
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Convenience of
searching the ten most general categories of each
term
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Usage
of one of the most reliable Biological Ontologies (Gene
Ontology) for the results’ extraction (well structured
ontologies based on biological evidence, widely accepted
nomenclature)
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